Het rechterlijk bevel en verbod als remedie

This dissertation discusses the injunction and whether there is a claim for a preventive remedy⁠. It explains how the injunction is regulated in Dutch law, when it can be pronounced and what the grounds for refusal are⁠.Using supranational law, the requirements that a remedy must meet to be effective are examined⁠. It concludes that a remedy is effective if it can enforce substantive rights, can be deployed in a timely manner, has a deterrent function and is proportionate⁠.Three themes are then used to examine whether the national regime is in line with those requirements⁠. In that regard, the role and freedom of the courts, the situation where performance has become impossible, and collective actions against the government are examined⁠.The conclusion is that the national regulation is adequate⁠.Coherent privaatrech

Two-year cost effectiveness between two gradual tapering strategies in rheumatoid arthritis: Cost-utility analysis of the TARA trial

Objective The aim of the current study was to evaluate the 2-year cost-utility ratio between tapering conventional synthetic disease-modifying antirheumatic drugs (csDMARD) first followed by the tumour necrosis factor (TNF)-inhibitor, or vice versa, in patients with rheumatoid arthritis (RA). Methods Two-year data of the Tapering strategies in Rheumatoid Arthritis trial were used. Patients with RA, who used both a csDMARD and a TNF-i

Molecular assessment of bacterial vaginosis by Lactobacillus abundance and species diversity

__Background:__ To date, women are most often diagnosed with bacterial vaginosis (BV) using microscopy based Nugent scoring or Amsel criteria. However, the accuracy is less than optimal. The aim of the present study was to confirm the identity of known BV-associated composition profiles and evaluate indicators for BV using three molecular methods. __Methods:__ Evaluation of indicators for BV was carried out by 16S rRNA amplicon sequencing of the V5-V7 region, a tailor-made 16S rRNA oligonucleotide-based microarray, and a PCR-based profiling technique termed IS-profiling, which is based on fragment variability of the 16S-23S rRNA intergenic spacer region. An inventory of vaginal bacterial species was obtained from 40 females attending a Dutch sexually transmitted infection outpatient clinic, of which 20 diagnosed with BV (Nugent score 7-10), and 20 BV negative (Nugent score 0-3). __Results:__ Analysis of the bacterial communities by 16S rRNA amplicon sequencing revealed two clusters in the BV negative women, dominated by either Lactobacillus iners or Lactobacillus crispatus and three distinct clusters in the BV positive women. In the former, there was a virtually complete, negative correlation between L. crispatus and L. iners. BV positive subjects showed cluster profiles that were relatively high in bacterial species diversity and dominated by anaerobic species, including Gardnerella vaginalis, an

Het rechterlijk bevel en verbod als remedie

This dissertation discusses the injunction and whether there is a claim for a preventive remedy⁠. It explains how the injunction is regulated in Dutch law, when it can be pronounced and what the grounds for refusal are⁠.Using supranational law, the requirements that a remedy must meet to be effective are examined⁠. It concludes that a remedy is effective if it can enforce substantive rights, can be deployed in a timely manner, has a deterrent function and is proportionate⁠.Three themes are then used to examine whether the national regime is in line with those requirements⁠. In that regard, the role and freedom of the courts, the situation where performance has become impossible, and collective actions against the government are examined⁠.The conclusion is that the national regulation is adequate⁠.</p

A two-stage mixed-effects model approach for gene-set analyses in candidate gene studies

Development and application of statistical models for medical scientific researc

When I don't get what I want, I take it because it's mine. I-D compensation and incarcerated adolescents in a delayed-return society: an application of Martin's theory

Martin (1999a) proposes that present-day society differs from mankind's evolutionary past by a change from immediate returns, when living as hunter-gatherers, to a delayed-return system with the onset of agriculture and urban living. He assumes that a delayed-return system lacks frequent feedback necessary for goal orientation and perceived control, which may lead to various social psychological thinking errors, cognitive distortions and an external locus of control. This study was aimed at examining whether Martin's I-D compensation theory could be applied in a sample of incarcerated juvenile delinquents in The Netherlands who frequently lack adequate feedback and control. Using questionnaires (N = 144) and semi-structured interviews (N = 40) with adolescents in secure institutional facilities, the results showed that feedback in the form of responsiveness of group workers was positively related to behavioural competence and subsequently to fewer criminal cognitions and self-serving cognitive distortions. In addition, self-serving cognitive distortions were positively associated with an external locus of control. These results provide insight into antecedents of criminal behaviour, and can be used to develop efficacious institutional treatment for juvenile delinquents

The association between work climate and group climate in a secure forensic treatment setting for individuals with mild intellectual disability or borderline intellectual functioning

We examined associations between group climate as perceived by 212 individuals with mild intellectual disability and work climate as experienced by 262 sociotherapists in a forensic setting. Results showed that if sociotherapists experienced more job satisfaction, they experienced less negative team functioning. Also, more positive team functioning was related to less repression. Workload and negative team functioning were related to less possibilities for growth by clients. No significant associations were found between other work climate and group climate dimensions. This study emphasized the importance of being aware of parallel processes between work climate and group climate in secure settings

Gender, culture and the living group climate

Background: This study focused on the cultural and gender differences in the perception of living group climate quality between native Dutch youth and Dutch youth with a Turkish and Moroccan cultural background placed in Dutch residential youth care. Method: Living group climate was examined by means of a self-report measure in a sample of 437 youth of whom were 178/173 native Dutch boys and girls, and 40/46 Turkish/Moroccan boys and girls. Living group climate was measured with the Group Climate Instrument that consists of four subscales (i.e. Support, Growth, Repression, and Atmosphere). Result: Results indicated that Turkish/Moroccan boys experienced significantly less support and growth in comparison to native Dutch boys. Conclusion: We conclude that a cultural sensitive approach in residential youth care is important by acknowledging the cultural values, specifically the collectivistic masculine identity of Turkish/Moroccan boys, to better meet basic psychological needs of these boys in residential care and improve treatment efficacy. Implications for future research and clinical practice are discussed