123 research outputs found

    A Study of the (3-He,t) Charge-Exchange Reaction at E(3-He) = 200 MeV

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    This research was sponsored by the National Science Foundation Grant NSF PHY 87-1440

    Fragmentation of High-Spin Particle-Hole States in 26-Mg

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    This work was supported by the National Science Foundation Grants NSF PHY 78-22774 A03, NSF PHY 81-14339, and by Indiana Universit

    Fragmentation of High-spin Particle-hole States in 26-Mg

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    This research was sponsored by the National Science Foundation Grant NSF PHy 87-1440

    Fragmentation of High-Spin Particle-Hole States in 26-Mg

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    This work was supported by the National Science Foundation Grant NSF PHY 81-14339 and by Indiana Universit

    3s Proton Holes in the Ground State of 208-Pb

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    This research was sponsored by the National Science Foundation Grant NSF PHY 87-1440

    Autoantibodies against type I IFNs in patients with life-threatening COVID-19

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    Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men

    Experimental progress in positronium laser physics

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