20 research outputs found

    Диагностика Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ сСрдСчно-сосудистой систСмы ΠΈ ишСмии ΠΌΠΈΠΎΠΊΠ°Ρ€Π΄Π° с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ магниторСзонансной Π²ΠΈΠ·ΡƒΠ°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ с контрастным усилСниСм

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    Показана Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡ‚ΡŒ выявлСния патологичСских ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Π² ΠΌΠΈΠΎΠΊΠ°Ρ€Π΄Π΅ (ΠΈΠ½Ρ„Π°Ρ€ΠΊΡ‚, ишСмия) ΠΈ сосудистой систСмС (стСноз) с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ магниторСзонансной Π²ΠΈΠ·ΡƒΠ°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ с контрастным усилСниСм.The possibility to reveal pathological changes in the myocardium (infarction, ischemia) and vascular system (stenosis) using magnetic resonance imaging with contrast enhancement is shown

    Genetics of Structural Brain Development and Cognition in Childhood and Early Adolescence

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    Boomsma, D.I. [Promotor]Hulshoff Pol, H.E. [Promotor]Brouwer, R.M. [Copromotor

    Genetic control of functional brain network efficiency in children

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    AbstractThe human brain is a complex network of interconnected brain regions. In adulthood, the brain's network was recently found to be under genetic influence. However, the extent to which genes influence the functional brain network early in development is not yet known. We report on the heritability of functional brain efficiency during early brain development. Using a twin design, young children underwent resting-state functional magnetic resonance imaging brain scans (N=86 from 21MZ and 22DZ twin-pairs, age=12 years). Functional connectivity, defined as the temporal dependency of neuronal activation patterns of anatomically separated brain regions, was explored using graph theory and its heritability was examined using structural equation modeling. Our findings suggest that β€˜global efficiency of communication’ among brain regions is under genetic control (h2 lambda=42%), irrespectively of the total number of brain connections (connectivity density). In addition, no influence of genes or common environment to local clustering (gamma) was found, suggesting a less pronounced effect of genes on local information segregation. Thus our findings suggest that a set of genes is shaping the underlying architecture of functional brain communication during development
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