322 research outputs found
A collaborative tool for mobilizing knowledge in agrobiodiversity and the interface with climate change: the Platform for Agrobiodiversity Research
Poster presented at 2nd ANAFE International Symposium. Lilongwe (Malawi), Jul 200
Long-term treatment effects of imagery rehearsal therapy for nightmares in a population with diverse mental disorders
3+1 dimensional Yang-Mills theory as a local theory of evolution of metrics on 3 manifolds
An explicit canonical transformation is constructed to relate the physical
subspace of Yang-Mills theory to the phase space of the ADM variables of
general relativity. This maps 3+1 dimensional Yang-Mills theory to local
evolution of metrics on 3 manifolds.Comment: 7 pages, revte
Phase III trial of Prophylactic Cranial Irradiation with or without Hippocampus Avoidance in SCLC
Different susceptibility of osteosarcoma cell lines and primary cells to treatment with oncolytic adenovirus and doxorubicin or cisplatin
Despite improvements in treatment regimens for osteosarcoma (OS) patients, survival rate has not increased over the last two decades. New treatment modalities are therefore warranted. Preclinical results with conditionally replicative adenoviruses (CRAds) to treat OS are promising. One type of CRAd that was effective against OS cells is Ad5-Δ24RGD. In other types of cancer, CRAds have been shown to interact synergistically with chemotherapeutic agents. Chemotherapy for OS often includes doxorubicin and cisplatin. Therefore, we explored combination treatment of OS cell lines and primary OS cell cultures with Ad5-Δ24RGD and doxorubicin or cisplatin. On OS cell lines, combination treatment was additive to synergistic. Surprisingly, however, on seven of eight primary OS samples no such combination effects were observed. In contrast, in many cases chemotherapy even inhibited CRAd-mediated cell killing. The inhibitory effect of doxorubicin on Ad5-Δ24RGD in primary OS cells appeared to correlate with slow cell growth rate; reduced viral replication and absence of chemotherapy-induced G2 cell cycle arrest. Our results point to the possibility that, at least for OS, virotherapy and chemotherapy should best not be performed simultaneously. In general, our work underscores the importance of testing new genetic anticancer agents and treatment regimens on primary cancer specimens
Scaling Properties of the Giant Dipole Resonance Width in Hot Rotating nuclei
We study the systematics of the giant dipole resonance width in hot
rotating nuclei as a function of temperature , spin and mass . We
compare available experimental results with theoretical calculations that
include thermal shape fluctuations in nuclei ranging from A=45 to A=208. Using
the appropriate scaled variables, we find a simple phenomenological function
which approximates the global behavior of the giant dipole
resonance width in the liquid drop model. We reanalyze recent experimental and
theoretical results for the resonance width in Sn isotopes and Pb.Comment: LaTeX, 4 pages with 4 figures (to appear in Phys. Rev. Lett.
Hysterectomy Does Not Cause Constipation
PURPOSE: This study was designed to evaluate the risk on development and persistence of constipation after hysterectomy. METHODS: We conducted a prospective, observational, multicenter study with three-year follow-up in 13 teaching and nonteaching hospitals in the Netherlands. A total of 413 females who underwent hysterectomy for benign disease other than symptomatic uterine prolapse were included. All patients underwent vaginal hysterectomy, subtotal abdominal hysterectomy, or total abdominal hysterectomy. A validated disease-specific quality-of-life questionnaire was completed before and three years after surgery to assess the presence of constipation. RESULTS: Of the 413 included patients, 344 (83 percent) responded at three-year follow-up. Constipation had developed in 7 of 309 patients (2 percent) without constipation before surgery and persisted in 16 of 35 patients (46 percent) with constipation before surgery. Preservation of the cervix seemed to be associated with an increased risk of the development of constipation (relative risk, 6.6; 95 percent confidence interval, 1.3-33.3; P=0.02). Statistically significant risk factors for the persistence of constipation could not be identified. CONCLUSIONS: Hysterectomy does not seem to cause constipation. In nearly half of the patients reporting constipation before hysterectomy, this symptom will disappear
Cognitive Impairment in Long-Term Survivors of Testicular Cancer More Than 20 Years after Treatment
Effect of Physical Exercise on MRI-Assessed Brain Perfusion in Chemotherapy-Treated Breast Cancer Patients:A Randomized Controlled Trial
The study design of UDRIVE: the Naturalistic Driving Study across Europe for cars, trucks and scooters
Purpose: UDRIVE is the first large-scale European Naturalistic Driving Study on cars, trucks and powered two wheelers. The acronym stands for "European naturalistic Driving and Riding for Infrastructure & Vehicle safety and Environment". The purpose of the study is to gain a better understanding of what happens on the road in everyday traffic situations. Methods: The paper describes Naturalistic Driving Studies, a method which provides insight into the actual real-world behaviour of road users, unaffected by experimental conditions and related biases. Naturalistic driving can be defined as a study undertaken to provide insight into driver behaviour during everyday trips by recording details of the driver, the vehicle and the surroundings through unobtrusive data gathering equipment and without experimental control. Data collection will take place in six EU Member States. Results: Road User Behaviour will be studied with a focus on both safety and environment. The UDRIVE project follows the steps of the FESTA-V methodology, which was originally designed for Field Operational Tests. Conclusions: Defining research questions forms the basis of the study design and the specification of the recording equipment. Both will be described in this paper. Although the project has just started collecting data from drivers, we consider the process of designing the study as a major result which may help other initiatives to set up similar studies
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