The Crisis of Causality:Voetius and Descartes on God, Nature and Change

The Crisis of Causality deals with the reaction of the Dutch Calvinist theologian Gisbertus Voetius (1589-1676) to the New Philosophy of René Descartes (1596-1650).Voetius not only criticised the Cartesian idea of a mechanical Universe; he also foresaw that shifting conceptions of natural causality would make it impossible for theologians to explain the relationship between God and Creation in philosophical terms. This threatened the status of theology as a scientific discipline.Apart from a detailed analysis of the Scholastic and Cartesian notions of causality, the book offers new perspectives on related subjects, such as seventeenth-century university training and the Cartesian method of science. It will be of great importance to any student of seventeenth-century intellectual history, philosophy, theology and history of science

Public Relations: Too Little Emphasis on Communication

Examining the literature on public relations, the notion emerges that all major public relations approaches recognize communication as a means to “do” public relations; some even use “communication” in the name of their approach. However, as a key concept that needs to be defined and discussed, communication is largely overlooked. After close reading of relevant literature in order to understand what is really understood under “communication”, there is hardly any reference to be found to (recent) communication theories. Is it because most public relations scholars seem to hold a non-communication view of communication

Blended Learning and Math Growth: Investigating the Role of IXL Math in the Growth of 5th Grade Students’ Math Fluency Scores

Because of an increase in usage of online adaptive technology in the classroom replacing much of the paper and pencil work previously given as math homework, this study was designed to compare the growth rates in MAPS (Measurement of Academic Progress) math scores between a control group of 5th grade students who did not have access to online practice and a treatment group of students who were assigned online practice throughout the school year. If growth rates were greater in the treatment group, this study could support the movement of decreasing the amount of traditional homework and implementing more online practice in its place. This study concluded that the treatment group out-performed the control group in overall scores and growth rates

Communication planning: Agility is a game changer in strategy development

The purpose of this conceptual article is to explore what agility means for communication planning. Agility is focused on adaptation to change. A review of current communication planning models shows that most models are focused on long-term detailed planning with little room to fully adapt to change. In contrast, agility encourages to focus on choices to be tested, not only at the output or tactic levels but for every choice in the strategy. This implies that we should alter our idea of evaluation as the final step in our planning models and focus much more on goal-based and goal-free formative evaluation, in order to test choices over and over again and show that strategy is not a product but a process of adaptation. The design of an agile communication strategy must be short and simple and show the coherence of the choices made. Based on the literature in business and marketing strategy modeling, a framework for an agile communication strategy with eight building blocks is presented. The intention of this model is to introduce a framework that helps to see strategy building as a narrative that ensures coherence in the choices made and offers room for fully adapting to change

Sharing a Stage in the Arena of Agency Freedom in Erasmus

Exactly five hundred years ago today, Erasmus engaged with Martin Luther in a debate on free will that continues to inspire, even if it evokes a notion of freedom that is no longer ours in every respect. Emphasising the need for a common-sense reading of Holy Scripture that did not require making conjectures about the existence of hidden forms of divine justice inconsistent with our own, Erasmus confronted Luther with the fact that his “necessitating” notion of grace was not in any way representative of earlier theological positions acknowledging the notion of free will. Refusing to be drawn towards an interpretation of grace that denied human beings the ability to activate the full spectrum of their natural reaction patterns, Erasmus stayed clear of translating earlier theological positions on grace in terms of an overruling of human agency. His theology continued to inspire later generations to work on their moral development rather than to act out of fear for divine retribution. Despite his name as a sceptic and a rhetorician, Erasmus’ decidedly this-worldly interpretation of religious doctrine not only reveals his argumentative agility and deep theoretical insight; it also prompts a universalist approach in theology that consistently favours a predisposition towards the humane.</p

BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors

BACKGROUND: As major regulators of normal chondrogenesis, the bone morphogenic protein (BMP) and transforming growth factor β (TGFB) signaling pathways may be involved in the development and progression of central chondrosarcoma. In order to uncover their possible implication, the aim of this study was to perform a systematic quantitative study of the expression of BMPs, TGFBs and their receptors and to assess activity of the corresponding pathways in central chondrosarcoma. METHODS: Gene expression analysis was performed by quantitative RT-PCR in 26 central chondrosarcoma and 6 healthy articular cartilage samples. Expression of endoglin and nuclear localization of phosphorylated Smad1/5/8 and Smad2 was assessed by immunohistochemical analysis. RESULTS: The expression of TGFB3 and of the activin receptor-like kinase ALK2 was found to be significantly higher in grade III compared to grade I chondrosarcoma. Nuclear phosphorylated Smad1/5/8 and Smad2 were found in all tumors analyzed and the activity of both signaling pathways was confirmed by functional reporter assays in 2 chondrosarcoma cell lines. Immunohistochemical analysis furthermore revealed that phosphorylated Smad1/5/8 and endoglin expression were significantly higher in high-grade compared to low-grade chondrosarcoma and correlated to each other. CONCLUSIONS: The BMP and TGFβ signaling pathways were found to be active in central chondrosarcoma cells. The correlation of Smad1/5/8 activity to endoglin expression suggests that, as described in other cell types, endoglin could enhance Smad1/5/8 signaling in high-grade chondrosarcoma cells. Endoglin expression coupled to Smad1/5/8 activation could thus represent a functionally important signaling axis for the progression of chondrosarcoma and a regulator of the undifferentiated phenotype of high-grade tumor cells

Bodies, Morals, and Religion: Utopia and the Erasmian Idea of Human Progress

Although Thomas More’s description of the Utopians’ ‘Epicurean’ position in philosophy nominally coincides with Erasmus’s defence of the Philosophia Christi, More shows no concern for the arguments Erasmus gave in support of this view. Taking its starting point from Erasmus’s depreciations of the body and More’s intellectual as well as physical preoccupations with the bodily sphere, this article presents the theme of the human body and its moral and religious significance as a test case for comparing Erasmus and More. The treatises both men wrote on Christ’s suffering in the Garden of Gethsemane confirm that both authors dealt with the notion of the body in contrasting ways: Erasmus shows a tendency to address the moral-psychological question of mentally conquering the worldly self, whilst More highlights the way in which ordinary facts and physical things may carry spiritual and religious meaning. Paradoxically, Erasmus consistently applied his spiritualized ideal of man to this-worldly moral and social concerns, whereas More focused on the physical domain out of a religious interest in transcendent truths. In line with Giulia Sissa’s thesis, our hypothesis is that More ostensibly appropriated an Erasmian type of idealism in Utopia, but, contrary to Erasmus himself, focused on the exterior form of a virtuous society, rather than on its moral and spiritual preconditions. While Erasmus advocated a mental transformation towards reason, More’s Utopia envisioned what might come of this