Synchronization of the parkinsonian globus pallidus by gap junctions

We introduce pallidal gap junctional coupling as a possible mechanism for synchronization of the GPe after dopamine depletion. In a confocal imaging study, we show the presence of the neural gap junction protein Cx36 in the human GPe, including a possible remodeling process in PD patients. Dopamine has been shown to down-regulate the conductance of gap junctions in different regions of the brain [2,3], making dopamine depletion a possible candidate for increased influence of gap junctional coupling in PD

Comparing Epileptiform Behavior of Mesoscale Detailed Models and Population Models of Neocortex

Two models of the neocortex are developed to study normal and pathologic neuronal activity. One model contains a detailed description of a neocortical microcolumn represented by 656 neurons, including superficial and deep pyramidal cells, four types of inhibitory neurons, and realistic synaptic contacts. Simulations show that neurons of a given type exhibit similar, synchronized behavior in this detailed model. This observation is captured by a population model that describes the activity of large neuronal populations with two differential equations with two delays. Both models appear to have similar sensitivity to variations of total network excitation. Analysis of the population model reveals the presence of multistability, which was also observed in various simulations of the detailed model

Controllable plasma energy bands in a 1D crystal of fractional Josephson vortices

We consider a 1D chain of fractional vortices in a long Josephson junction with alternating $\pm\kappa$ phase discontinuities. Since each vortex has its own eigenfrequency, the inter-vortex coupling results in eigenmode splitting and in the formation of an oscillatory energy band for plasma waves. The band structure can be controlled at the design time by choosing the distance between vortices or \emph{during experiment} by varying the topological charge of vortices or the bias current. Thus one can construct an artificial vortex crystal with controllable energy bands for plasmons.Comment: 4 pages, 2 Fig