Nitrogen source apportionment for the catchment, estuary and adjacent coastal waters of the Scheldt.

Using the systems approach framework (SAF), a coupled model suite was developed for simulating land-use decision making in response to nutrient abatement costs and water and nutrient fluxes in the hydrological network of the Scheldt River, and nutrient fluxes in the estuary and adjacent coastal sea. The purpose was to assess the efficiency of different long-term water quality improvement measures in current and future climate and societal settings, targeting nitrogen (N) load reduction. The spatial-dynamic model suite consists of two dynamically linked modules: PCRaster is used for the drainage network and is combined with ExtendSim modules for farming decision making and estuarine N dispersal. Model predictions of annual mean flow and total N concentrations compared well with data available for river and estuary (r² ≥ 0.83). Source apportionment was carried out to societal sectors and administrative regions; both households and agriculture are the major sources of N, with the regions of Flanders and Wallonia contributing most. Load reductions by different measures implemented in the model were comparable (~75% remaining after 30 yr), but costs differed greatly. Increasing domestic sewage connectivity was more effective, at comparatively low cost (47% remaining). The two climate scenarios did not lead to major differences in load compared with the business-as-usual scenario (~88% remaining). Thus, this spatially explicit model of water flow and N fluxes in the Scheldt catchment can be used to compare different long-term policy options for N load reduction to river, estuary, and receiving sea in terms of their effectiveness, cost, and optimal location of implementation

Lipoproteins act as vehicles for lipid antigen delivery and activation of invariant natural killer T cells

Invariant natural killer T (iNKT) cells act at the interface between lipid metabolism and immunity because of their restriction to lipid antigens presented on CD1d by antigen-presenting cells (APCs). How foreign lipid antigens are delivered to APCs remains elusive. Since lipoproteins routinely bind glycosylceramides structurally similar to lipid antigens, we hypothesized that circulating lipoproteins form complexes with foreign lipid antigens. In this study, we used 2-color fluorescence correlation spectroscopy to show, for the first time to our knowledge, stable complex formation of lipid antigens alpha-galactosylceramide (alpha GalCer), isoglobotrihexosylceramide, and OCH, a sphingosine-truncated analog of alpha GalCer, with VLDL and/or LDL in vitro and in vivo. We demonstrate LDL receptor-mediated (LDLR-mediated) uptake of lipoprotein-alpha GalCer complexes by APCs, leading to potent complex-mediated activation of iNKT cells in vitro and in vivo. Finally, LDLR-mutant PBMCs of patients with familial hypercholesterolemia showed impaired activation and proliferation of iNKT cells upon stimulation, underscoring the relevance of lipoproteins as a lipid antigen delivery system in humans. Taken together, circulating lipoproteins form complexes with lipid antigens to facilitate their transport and uptake by APCs, leading to enhanced iNKT cell activation. This study thereby reveals a potentially novel mechanism of lipid antigen delivery to APCs and provides further insight into the immunological capacities of circulating lipoproteins.Metabolic health: pathophysiological trajectories and therap

Design for divestment in a circular economy: Stimulating voluntary return of smartphones through design

For the transition toward a circular economy, it is essential that products are returned for reuse, refurbishing or recycling. In order to address the lack of literature on the topic from a user perspective, this paper explores how users can be stimulated to return used smartphones. Taking a Research through Design approach, we developed a novel set of "design for divestment" principles. Divestment is the process users experience when separating from a product. After introducing a conceptual model of divestment based on an extension of the Consumer Decision Process model by Blackwell, Engel, and Miniard, we describe seven empirical studies (i.e., design projects) into smartphone divestment. The studies explore factors that influence a successful divestment process. We report on a highly complex process with interrelated factors changing over time. While it is impossible to define a blueprint for an ideal divestment process, several patterns emerged such as the need to emotionally support users, to give them confidence regarding data security, and to provide information at the right moment. These unique insights contribute to consumer research (i.e., circular consumption); and by translating the insights to ten design principles for divestment, a novel contribution is made to the field of design research.</p

Design for divestment in a circular economy: Stimulating voluntary return of smartphones through design

For the transition toward a circular economy, it is essential that products are returned for reuse, refurbishing or recycling. In order to address the lack of literature on the topic from a user perspective, this paper explores how users can be stimulated to return used smartphones. Taking a Research through Design approach, we developed a novel set of "design for divestment" principles. Divestment is the process users experience when separating from a product. After introducing a conceptual model of divestment based on an extension of the Consumer Decision Process model by Blackwell, Engel, and Miniard, we describe seven empirical studies (i.e., design projects) into smartphone divestment. The studies explore factors that influence a successful divestment process. We report on a highly complex process with interrelated factors changing over time. While it is impossible to define a blueprint for an ideal divestment process, several patterns emerged such as the need to emotionally support users, to give them confidence regarding data security, and to provide information at the right moment. These unique insights contribute to consumer research (i.e., circular consumption); and by translating the insights to ten design principles for divestment, a novel contribution is made to the field of design research.Industrial Design EngineeringCircular Product DesignDesign for Sustainabilit

Does Access Trump Ownership?: Exploring Consumer Acceptance of Access-Based Consumption in the Case of Smartphones

Value creation in a circular economy is based on products being returned after use. In the case of smartphones, most are never returned and tend to be kept in drawers. Smartphone access services (e.g., leasing or upgrade) have been experimented with in the Netherlands but have been largely unsuccessful. This study explores the reasons why consumers rejected these access-based smartphone services and is one of the very few to address this topic. The findings are compared with the case of car access services, which are socially better accepted, to identify potential areas for improvement. The qualitative study consists of in-depth interviews with consumers (n = 18) who either adopted and used a smartphone or car access service, or had considered a new smartphone or car but did not choose access-based consumption. The findings of this small-scale study suggest that the main reasons for the rejection of smartphone access services are a lack of awareness, misunderstanding of terms and conditions, and unsatisfactory compensation for their sacrifice of not owning. Smartphone access providers could thus clearly communicate customers’ rights and responsibilities, offer an excellent service experience (especially during repair) by taking over the burdens of ownership, and stimulate the societal logic shift from ownership to access.Circular Product DesignDesign for Sustainabilit