Verteerbaarheid en voederwaarde van eiwitrijke grondstoffen bij biologische biggen

Op Varkensproefbedrijf Raalte is onderzocht wat de nutriëntensamenstelling, verteerbaarheid en EW is van raapzaadeiwit concentraat, erwteneiwit concentraat, tarweglutenmeel en veldboneneiwitconcentraat bij biologisch gehouden gespeende biggen. De resultaten van het onderzoek zijn in dit rapport beschreven

MÖSSBAUER EFFECT AND MAGNETIC PROPERTIES OF AN AMORPHOUS Fe2O3

Un oxyde amorphe de fer (III) a été préparé par décomposition thermique d'un aérosol sur un substrat chauffé. Les mesures de la susceptibilité magnétique montrent une température de Néel de 80 K. En dessous de 50 K on observe un moment thermo-remanent. Le moment paramagnétique est de 2,5 µB par ion de fer, indiquant la présence d'aggrégats antiferromagnétiques. Les spectres Mössbauer montrent un doublet paramagnétique au-dessus de 80 K avec un déplacement isomérique de + 0,15 mm/s. En dessous de 80 K une séparation hyperfine est observée avec, à 5 K, Hhf = 470 kOe et ΔEQ = 0,11 mm/s. Il en est déduit que les ions Fe3+ sont entourés par un octaèdre déformé d'ions O2-. Leurs axes de symétrie sont orientés arbitrairement dans la maille apériodique, laissant une large dispersion des angles ν entre Hhf et Vzz.An amorphous iron (III) oxide was prepared by thermal decomposition of an aerosol on a heated substrate. Magnetic susceptibility measurements show a Néel temperature of 80 K. Below 50 K a thermoremanent moment is observed. The paramagnetic moment amounts to 2.5 µB per iron ion, indicating antiferromagnetic clustering. Mössbauer spectra show a paramagnetic doublet above 80 K with an isomer shift of + 0.15 mm/s and a quadrupole splitting of 1.01 mm/s ; below 80 K a hyperfine split spectrum is found with, at 5 K, Hhf = 470 kOe and ΔEQ = 0.11 mm/s. It is derived that the Fe3+ ions are coordinated by a distorted octahedron of O2- ions. Their symmetry axes are randomly oriented in the aperiodic lattice, leaving a wide distribution of angles ν between Hhf and Vz

Immune responsiveness in renal transplant recipients: mycophenolic acid severely depresses humoral immunity in vivo

BACKGROUND: Current immunosuppressive drug treatments for renal transplant recipients result in high one-year graft survival rates. Despite adequate suppression of the immune response directed to the allograft, the immune system remains able to cope with many infectious agents. METHODS: To define the influence of distinct immunosuppressive treatment protocols, primary and secondary cellular and humoral immune responses in groups of renal transplant recipients were studied: patient treated with prednisolone and cyclosporine A (P/CsA); with IgA CD3 monoclonal antibody as a rejection treatment superimposed on prednisolone and cyclosporine A (IgA CD3 mAb+P/CsA); and with prednisolone, cyclosporine A and mycophenolate mofetil (P/CsA/MMF). RESULTS: Primary in vitro proliferative responses to the protein antigen keyhole limpet hemocyanin (KLH) were not significantly disturbed in P/CsA treated patients, or in IgA CD3 mAb+P/CsA and P/CsA/MMF treated patients. In vitro proliferative responses to the recall antigen tetanus toxoid (TT) were similarly unaffected. Antigen-specific antibody responses to immunization with KLH and TT were not affected by treatment with P/CsA, or by IgA CD3 mAb+P/CsA, but were severely disturbed in patients treated with P/CsA/MMF. All patients displayed a profound inhibition of the delayed-type hypersensitivity skin reactivity to KLH and recall antigens. Nevertheless, in most patients with P/CsA treatment, T cell infiltrates were observed in skin biopsies from the site of KLH challenge, while expression of intercellular cell adhesion molecule-1 (ICAM-1) expression in challenged skin was significantly decreased in these patients. The balance between T helper 1 and T helper 2 cells was unaffected by immunosuppressive treatments during one year of follow-up. CONCLUSIONS: Immunosuppressive drug treatment with P/CsA inhibits delayed-type hypersensitivity skin reactions to both primary and frequently encountered antigens. Histological studies indicate an effect on ICAM-1 expression, leaving the influx of CD3pos T cells unaffected. Administration of a 10-day course of IgA CD3 mAb does not add profound immunosuppressive effects on the measured parameters. In contrast, addition of treatment with MMF profoundly decreases both primary and secondary humoral immune responsiveness in vivo. Finally, no effect of the studied immunosuppressive drugs on Th1/Th2 balance in vivo was measure

Update in Perioperative Medicine 2012

Perioperative medicine is an increasing area of research focus that brings together internists, anesthesiologists, surgeons, and hospitalists. A medical team approach to ensure the best possible patient outcomes has fostered collaborative strategies across areas of patient care. We review 8 seminal articles in the field of perioperative medicine. Each article was published in either 2011 or 2012 and adds to care strategies in the areas of perioperative cardiac medicine, pulmonary care, blood transfusion decision making, and medication management