Damage to fronto-parietal networks impairs motor imagery ability after stroke : a voxel-based lesion symptom mapping study

Background: mental practice with motor imagery has been shown to promote motor skill acquisition in healthy subjects and patients. Although lesions of the common motor imagery and motor execution neural network are expected to impair motor imagery ability, functional equivalence appears to be at least partially preserved in stroke patients.Aim: to identify brain regions that are mandatory for preserved motor imagery ability after stroke.Method: thirty-seven patients with hemiplegia after a first time stroke participated. Motor imagery ability was measured using a Motor Imagery questionnaire and temporal congruence test. A voxelwise lesion symptom mapping approach was used to identify neural correlates of motor imagery in this cohort within the first year post-stroke.Results: poor motor imagery vividness was associated with lesions in the left putamen, left ventral premotor cortex and long association fibres linking parieto-occipital regions with the dorsolateral premotor and prefrontal areas. Poor temporal congruence was otherwise linked to lesions in the more rostrally located white matter of the superior corona radiata. Conclusion: This voxel-based lesion symptom mapping study confirms the association between white matter tract lesions and impaired motor imagery ability, thus emphasizing the importance of an intact fronto-parietal network for motor imagery. Our results further highlight the crucial role of the basal ganglia and premotor cortex when performing motor imagery tasks

Attenuation and damping of electromagnetic fields: Influence of inertia and displacement current

New results for attenuation and damping of electromagnetic fields in rigid conducting media are derived under the conjugate influence of inertia due to charge carriers and displacement current. Inertial effects are described by a relaxation time for the current density in the realm of an extended Ohm's law. The classical notions of poor and good conductors are rediscussed on the basis of an effective electric conductivity, depending on both wave frequency and relaxation time. It is found that the attenuation for good conductors at high frequencies depends solely on the relaxation time. This means that the penetration depth saturates to a minimum value at sufficiently high frequencies. It is also shown that the actions of inertia and displacement current on damping of magnetic fields are opposite to each other. That could explain why the classical decay time of magnetic fields scales approximately as the diffusion time. At very small length scales, the decay time could be given either by the relaxation time or by a fraction of the diffusion time, depending whether inertia or displacement current, respectively, would prevail on magnetic diffusion.Comment: 21 pages, 1 figur

Quantized Roentgen Effect in Bose-Einstein Condensates

A classical dielectric moving in a charged capacitor can create a magnetic field (Roentgen effect). A quantum dielectric, however, will not produce a magnetization, except at vortices. The magnetic field outside the quantum dielectric appears as the field of quantized monopoles

Theory of Supercoupling, Squeezing Wave Energy, and Field Confinement in Narrow Channels and Tight Bends Using Epsilon-Near-Zero Metamaterials

In this work, we investigate the detailed theory of the supercoupling, anomalous tunneling effect, and field confinement originally identified in [M. Silveirinha, N. Engheta, Phys. Rev. Lett. 97, 157403, (2006)], where we demonstrated the possibility of using materials with permittivity near zero to drastically improve the transmission of electromagnetic energy through a narrow irregular channel with very subwavelength transverse cross-section. Here, we present additional physical insights, describe new applications of the tunneling effect in relevant waveguide scenarios (e.g., the "perfect" or "super" waveguide coupling), study the effect of metal losses in the metallic walls, and the possibility of using epsilon-near zero materials to confine energy in a subwavelength cavity with gigantic field enhancement. In addition, we systematically study the propagation of electromagnetic waves through narrow channels filled with anisotropic epsilon-near zero materials. It is demonstrated that these materials may have interesting potentials, and that for some particular geometries the reflectivity of the channel is independent of the specific dimensions or parameters of epsilon-near zero transition. We also describe several realistic metamaterial implementations of the studied problems, based on standard metallic waveguides, microstrip line configurations, and wire media.Comment: under revie

Differential Form Valued Forms and Distributional Electromagnetic Sources

Properties of a fundamental double-form of bi-degree $(p,p)$ for $p\ge 0$ are reviewed in order to establish a distributional framework for analysing equations of the form $$\Delta \Phi + \lambda^2 \Phi = {\cal S}$$ where $\Delta$ is the Hodge-de Rham operator on $p-$forms $\Phi$ on ${\bf R}^3$. Particular attention is devoted to singular distributional solutions that arise when the source ${\cal S}$ is a singular $p-$form distribution. A constructive approach to Dirac distributions on (moving) submanifolds embedded in ${\bf R}^3$ is developed in terms of (Leray) forms generated by the geometry of the embedding. This framework offers a useful tool in electromagnetic modeling where the possibly time dependent sources of certain physical attributes, such as electric charge, electric current and polarization or magnetization, are concentrated on localized regions in space.Comment: 40 page

First-Principle Homogenization Theory for Periodic Metamaterials

We derive from first principles an accurate homogenized description of periodic metamaterials made of magnetodielectric inclusions, highlighting and overcoming relevant limitations of standard homogenization methods. We obtain closed-form expressions for the effective constitutive parameters, pointing out the relevance of inherent spatial dispersion effects, present even in the long-wavelength limit. Our results clarify the limitations of quasi-static homogenization models, restore the physical meaning of homogenized metamaterial parameters and outline the reasons behind magnetoelectric coupling effects that may arise also in the case of center-symmetric inclusions.Comment: 58 pages, 10 figures Phys. Rev. B, in press (2011

Gauge Theories with Cayley-Klein SO(2;j)SO(2;j) and SO(3;j)SO(3;j) Gauge Groups

Gauge theories with the orthogonal Cayley-Klein gauge groups $SO(2;j)$ and $SO(3;{\bf j})$ are regarded. For nilpotent values of the contraction parameters ${\bf j}$ these groups are isomorphic to the non-semisimple Euclid, Newton, Galilei groups and corresponding matter spaces are fiber spaces with degenerate metrics. It is shown that the contracted gauge field theories describe the same set of fields and particle mass as $SO(2), SO(3)$ gauge theories, if Lagrangians in the base and in the fibers all are taken into account. Such theories based on non-semisimple contracted group provide more simple field interactions as compared with the initial ones.Comment: 14 pages, 5 figure

A rigorous analysis of high order electromagnetic invisibility cloaks

There is currently a great deal of interest in the invisibility cloaks recently proposed by Pendry et al. that are based in the transformation approach. They obtained their results using first order transformations. In recent papers Hendi et al. and Cai et al. considered invisibility cloaks with high order transformations. In this paper we study high order electromagnetic invisibility cloaks in transformation media obtained by high order transformations from general anisotropic media. We consider the case where there is a finite number of spherical cloaks located in different points in space. We prove that for any incident plane wave, at any frequency, the scattered wave is identically zero. We also consider the scattering of finite energy wave packets. We prove that the scattering matrix is the identity, i.e., that for any incoming wave packet the outgoing wave packet is the same as the incoming one. This proves that the invisibility cloaks can not be detected in any scattering experiment with electromagnetic waves in high order transformation media, and in particular in the first order transformation media of Pendry et al. We also prove that the high order invisibility cloaks, as well as the first order ones, cloak passive and active devices. The cloaked objects completely decouple from the exterior. Actually, the cloaking outside is independent of what is inside the cloaked objects. The electromagnetic waves inside the cloaked objects can not leave the concealed regions and viceversa, the electromagnetic waves outside the cloaked objects can not go inside the concealed regions. As we prove our results for media that are obtained by transformation from general anisotropic materials, we prove that it is possible to cloak objects inside general crystals.Comment: The final version is now published in Journal of Physics A: Mathematical and Theoretical, vol 41 (2008) 065207 (21 pp). Included in IOP-Selec

Platelets of patients with chronic kidney disease demonstrate deficient platelet reactivity in vitro

<p>Abstract</p> <p>Background</p> <p>In patients with chronic kidney disease studies focusing on platelet function and properties often are non-conclusive whereas only few studies use functional platelet tests. In this study we evaluated a recently developed functional flow cytometry based assay for the analysis of platelet function in chronic kidney disease.</p> <p>Methods</p> <p>Platelet reactivity was measured using flow cytometric analysis. Platelets in whole blood were triggered with different concentrations of agonists (TRAP, ADP, CRP). Platelet activation was quantified with staining for P-selectin, measuring the mean fluorescence intensity. Area under the curve and the concentration of half-maximal response were determined.</p> <p>Results</p> <p>We studied 23 patients with chronic kidney disease (9 patients with cardiorenal failure and 14 patients with end stage renal disease) and 19 healthy controls. Expression of P-selectin on the platelet surface measured as mean fluorescence intensity was significantly less in chronic kidney disease patients compared to controls after maximal stimulation with TRAP (9.7 (7.9-10.8) vs. 11.4 (9.2-12.2), P = 0.032), ADP (1.6 (1.2-2.1) vs. 2.6 (1.9-3.5), P = 0.002) and CRP (9.2 (8.5-10.8) vs. 11.5 (9.5-12.9), P = 0.004). Also the area under the curve was significantly different. There was no significant difference in half-maximal response between both groups.</p> <p>Conclusion</p> <p>In this study we found that patients with chronic kidney disease show reduced platelet reactivity in response of ADP, TRAP and CRP compared to controls. These results contribute to our understanding of the aberrant platelet function observed in patients with chronic kidney disease and emphasize the significance of using functional whole blood platelet activation assays.</p