3,329 research outputs found
Joint Deep Modeling of Users and Items Using Reviews for Recommendation
A large amount of information exists in reviews written by users. This source
of information has been ignored by most of the current recommender systems
while it can potentially alleviate the sparsity problem and improve the quality
of recommendations. In this paper, we present a deep model to learn item
properties and user behaviors jointly from review text. The proposed model,
named Deep Cooperative Neural Networks (DeepCoNN), consists of two parallel
neural networks coupled in the last layers. One of the networks focuses on
learning user behaviors exploiting reviews written by the user, and the other
one learns item properties from the reviews written for the item. A shared
layer is introduced on the top to couple these two networks together. The
shared layer enables latent factors learned for users and items to interact
with each other in a manner similar to factorization machine techniques.
Experimental results demonstrate that DeepCoNN significantly outperforms all
baseline recommender systems on a variety of datasets.Comment: WSDM 201
Recommended from our members
Rapid, efficient, and economical synthesis of PET tracers in a droplet microreactor: application to O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET).
BackgroundConventional scale production of small batches of PET tracers (e.g. for preclinical imaging) is an inefficient use of resources. Using O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET), we demonstrate that simple microvolume radiosynthesis techniques can improve the efficiency of production by consuming tiny amounts of precursor, and maintaining high molar activity of the tracers even with low starting activity.ProceduresThe synthesis was carried out in microvolume droplets manipulated on a disposable patterned silicon "chip" affixed to a heater. A droplet of [18F]fluoride containing TBAHCO3 was first deposited onto a chip and dried at 100 °C. Subsequently, a droplet containing 60 nmol of precursor was added to the chip and the fluorination reaction was performed at 90 °C for 5 min. Removal of protecting groups was accomplished with a droplet of HCl heated at 90 °C for 3 min. Finally, the crude product was collected in a methanol-water mixture, purified via analytical-scale radio-HPLC and formulated in saline. As a demonstration, using [18F]FET produced on the chip, we prepared aliquots with different molar activities to explore the impact on preclinical PET imaging of tumor-bearing mice.ResultsThe microdroplet synthesis exhibited an overall decay-corrected radiochemical yield of 55 ± 7% (n = 4) after purification and formulation. When automated, the synthesis could be completed in 35 min. Starting with < 370 MBq of activity, ~ 150 MBq of [18F]FET could be produced, sufficient for multiple in vivo experiments, with high molar activities (48-119 GBq/μmol). The demonstration imaging study revealed the uptake of [18F]FET in subcutaneous tumors, but no significant differences in tumor uptake as a result of molar activity differences (ranging 0.37-48 GBq/μmol) were observed.ConclusionsA microdroplet synthesis of [18F]FET was developed demonstrating low reagent consumption, high yield, and high molar activity. The approach can be expanded to tracers other than [18F]FET, and adapted to produce higher quantities of the tracer sufficient for clinical PET imaging
Using Markov Models and Statistics to Learn, Extract, Fuse, and Detect Patterns in Raw Data
Many systems are partially stochastic in nature. We have derived data driven
approaches for extracting stochastic state machines (Markov models) directly
from observed data. This chapter provides an overview of our approach with
numerous practical applications. We have used this approach for inferring
shipping patterns, exploiting computer system side-channel information, and
detecting botnet activities. For contrast, we include a related data-driven
statistical inferencing approach that detects and localizes radiation sources.Comment: Accepted by 2017 International Symposium on Sensor Networks, Systems
and Securit
Variation at APOE and STH loci and Alzheimer's disease
BACKGROUND: The apolipoprotein E (APOE) and tau proteins play important roles in the pathological development of Alzheimer's disease (AD). Many studies have shown an association between the APOE gene and AD. Association between AD and the newly discovered saitohin (STH) gene, nested within the intron of the tau gene, has been reported. The present study aimed to elucidate the association between APOE and AD, and between STH and AD in our sample. METHODS: The functional polymorphisms, rs429358 and rs7412, in the APOE gene (which together define the ε2, ε3, and ε4 alleles), and the Q7R SNP in the STH gene, were genotyped in 369 patients with AD and 289 healthy European-Americans. The associations between these two genes and AD were analyzed in a case-control design. RESULTS: Consistent with previously reported results, the frequencies of the APOE ε4 allele, ε4/ε4 genotype and ε3/ε4 genotype were significantly higher in AD cases than controls; the ε4/ε4 genotype frequency was significantly higher in early-onset AD (EOAD) than late-onset AD (LOAD); the frequencies of the ε2 allele, ε3 allele, ε3/ε3 genotype and ε2/ε3 genotype were significantly lower in AD cases than controls. Positive likelihood ratios (LRs(+)) of APOE alleles and genotypes increased in a linear trend with the number of ε4 alleles and decreased in a linear trend with the number of ε2 or ε3 alleles. There was no significant difference in the STH allele and genotype frequency distributions between AD cases and controls. CONCLUSION: This study confirmed that the ε4 allele is a dose-response risk factor for AD and the ε4/ε4 genotype was associated with a significantly earlier age of onset. Moreover, we found that the ε2 allele was a dose-response protective factor for AD and the ε3 allele exerted a weaker dose-response protective effect for risk of AD compared with ε2. In a clinical setting, APOE genotyping could offer additional biological evidence of whether a subject may develop AD, but it is not robust enough to serve as an independent screening or predictive test in the diagnosis of AD. STH variation was not significantly associated with AD in our sample
Heat capacity studies of Ce and Rh site substitution in the heavy fermion antiferromagnet CeRhIn_5;: Short-range magnetic interactions and non-Fermi-liquid behavior
In heavy fermion materials superconductivity tends to appear when long range
magnetic order is suppressed by chemical doping or applying pressure. Here we
report heat capacity measurements on diluted alloyes of the heavy fermion
superconductor CeRhIn_5;. Heat capacity measurements have been performed on
CeRh_{1-y}Ir_{y}In_5; (y <= 0.10) and Ce_{1-x}La_{x}Rh_{1-y}Ir_{y}In_5; (x <=
0.50) in applied fields up to 90 kOe to study the affect of doping and magnetic
field on the magnetic ground state. The magnetic phase diagram of
CeRh_{0.9}Ir_{0.1}In_5; is consistent with the magnetic structure of CeRhIn_5;
being unchanged by Ir doping. Doping of Ir in small concentrations is shown to
slightly increase the antiferromagnetic transition temperature T_{N} (T_{N}=3.8
K in the undoped sample). La doping which causes disorder on the Ce sublattice
is shown to lower T_{N} with no long range order observed above 0.34 K for
Ce_{0.50}La_{0.50}RhIn_5;. Measurements on Ce_{0.50}La_{0.50}RhIn_5; show a
coexistence of short range magnetic order and non-Fermi-liquid behavior. This
dual nature of the Ce 4f-electrons is very similar to the observed results on
CeRhIn_5; when long range magnetic order is suppressed at high pressure.Comment: 8 pages, 9 figure
Thermal fission rate around super-normal phase transition
Using Langer's method, we discuss the temperature dependence of
nuclear fission width in the presence of dissipative environments. We introduce
a low cut-off frequency to the spectral density of the environmental
oscillators in order to mimic the pairing gap. It is shown that the decay width
rapidly decreases at the critical temperature, where the phase transition from
super to normal fluids takes place. Relation to the recently observed threshold
for the dissipative fission is discussed.Comment: 12 pages, Latex, Submitted to Physical Review C for publication, 3
Postscript figures are available by request from
[email protected]
The temperature and chronology of heavy-element synthesis in low-mass stars
Roughly half of the heavy elements (atomic mass greater than that of iron)
are believed to be synthesized in the late evolutionary stages of stars with
masses between 0.8 and 8 solar masses. Deep inside the star, nuclei (mainly
iron) capture neutrons and progressively build up (through the
slow-neutron-capture process, or s-process) heavier elements that are
subsequently brought to the stellar surface by convection. Two neutron sources,
activated at distinct temperatures, have been proposed: 13C and 22Ne, each
releasing one neutron per alpha-particle (4He) captured. To explain the
measured stellar abundances, stellar evolution models invoking the 13C neutron
source (which operates at temperatures of about one hundred million kelvin) are
favoured. Isotopic ratios in primitive meteorites, however, reflecting
nucleosynthesis in the previous generations of stars that contributed material
to the Solar System, point to higher temperatures (more than three hundred
million kelvin), requiring at least a late activation of 22Ne. Here we report a
determination of the s-process temperature directly in evolved low-mass giant
stars, using zirconium and niobium abundances, independently of stellar
evolution models. The derived temperature supports 13C as the s-process neutron
source. The radioactive pair 93Zr-93Nb used to estimate the s-process
temperature also provides, together with the pair 99Tc-99Ru, chronometric
information on the time elapsed since the start of the s-process, which we
determine to be one million to three million years.Comment: 30 pages, 10 figure
Phase synchronization of autonomous AC grid system with passivity-based control
This paper discusses a ring‐coupled buck‐type inverter system to harness energy from direct current (DC) sources of electricity. The DC‐DC buck converter circuit is modified with an H‐bridge to convert the DC input voltage to a usable alternating current (AC) output voltage. Passivity‐based control (PBC) with port‐controlled Hamiltonian modelling (PCHM) is a method where the system is controlled by considering not only the energy properties of the system but also the inherent physical structure. PBC is applied to achieve stabilization of the AC output voltage to a desired amplitude and frequency. Unsynchronized output voltages in terms of phase angle or frequency can cause detrimental effects on the system. Phase‐locked loop (PLL) is employed in the ring structure to maintain synchronization of the AC output voltage of all inverter units in the ring‐coupled system
Magnetic control of large room-temperature polarization
Numerous authors have referred to room-temperature magnetic switching of
large electric polarizations as The Holy Grail of magnetoelectricity.We report
this long-sought effect using a new physical process of coupling between
magnetic and ferroelectric relaxor nano-regions. Here we report magnetic
switching between the normal ferroelectric state and the ferroelectric relaxor
state. This gives both a new room-temperature, single-phase, multiferroic
magnetoelectric, PbZr0.46Ti0.34Fe0.13W0.07O3, with polarization, loss (<4%),
and resistivity (typically 108 -109 ohm.cm) equal to or superior to BiFeO3, and
also a new and very large magnetoelectric effect: switching not from +Pr to
negative Pr with applied H, but from Pr to zero with applied H of less than a
Tesla. This switching of the polarization occurs not because of a conventional
magnetically induced phase transition, but because of dynamic effects:
Increasing H lengthens the relaxation time by x500 from 100 ?s, and
it couples strongly the polarization relaxation and spin relaxations. The
diverging polarization relaxation time accurately fits a modified Vogel-Fulcher
Equation in which the freezing temperature Tf is replaced by a critical
freezing field Hf that is 0.92 positive/negative 0.07 Tesla. This field
dependence and the critical field Hc are derived analytically from the
spherical random bond random field (SRBRF) model with no adjustable parameters
and an E2H2 coupling. This device permits 3-state logic (+Pr,0,negative Pr) and
a condenser with >5000% magnetic field change in its capacitance.Comment: 20 pages, 5 figure
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