3,158 research outputs found
E1-Like Activating Enzyme Atg7 Is Preferentially Sequestered into p62 Aggregates via Its Interaction with LC3-I
p62 is constitutively degraded by autophagy via its interaction with LC3. However, the interaction of p62 with LC3 species in the context of the LC3 lipidation process is not specified. Further, the p62-mediated protein aggregation's effect on autophagy is unclear. We systemically analyzed the interactions of p62 with all known Atg proteins involved in LC3 lipidation. We find that p62 does not interact with LC3 at the stages when it is being processed by Atg4B or when it is complexed or conjugated with Atg3. p62 does interact with LC3-I and LC3-I:Atg7 complex and is preferentially recruited by LC3-II species under autophagic stimulation. Given that Atg4B, Atg3 and LC3-Atg3 are indispensable for LC3-II conversion, our study reveals a protective mechanism for Atg4B, Atg3 and LC3-Atg3 conjugate from being inappropriately sequestered into p62 aggregates. Our findings imply that p62 could potentially impair autophagy by negatively affecting LC3 lipidation and contribute to the development of protein aggregate diseases. © 2013 Gao et al
Majorana bound state in rotating superfluid 3He-A between parallel plates
A concrete and experimentally feasible example for testing the putative
Majorana zero energy state bound in a vortex is theoretically proposed for a
parallel plate geometry of superfluid He-A phase. We examine the
experimental setup in connection with ongoing rotating cryostat experiments.
The theoretical analysis is based on the well-established Ginzburg--Landau
functional, supplemented by microscopic calculations of the Bogoliubov--de
Gennes equation, both of which allow the precise location of the parameter
regions of the Majorana state to be found in realistic situations.Comment: 5 pages, 4 figure
Lateral distribution of electrons of air showers
The lateral distribution of electrons (LDE) of the air showers of size 10 to the 5th power to 10 to the 6th power was studied within one MU. It was found that the LDE of the air showers observed is well represented by NKG function except for vicinity of the core. It was also found that LDE measured by thin scintillators does not differ from that measured by thick ones of 50mm thickness
Transition effect of air shower particles in plastic scintillators
The transition effect of air shower particles in the plastic scintillators near the core was measured by scintillators of various thickness. The air showers selected for the measurement were of 10,000. Results obtained are as follows: (1) the multiplication of shower particles in the scintillators is less than 20% for that of 50 mm thickness; (2) dependence of the transition effect on age parameter is not recognized within the experimental errors
Character of energy flow in air shower core
Energy per charged particle near the core of air showers was measured by 9 energy flow detectors, which were the combination of Cerenkov counters and scintillators. Energy per particle of each detector was normalized to energy at 2m from the core. The following results were obtained as to the energy flow: (1) integral frequency distribution of mean energy per particle (averaged over 9 detectors) is composed of two groups separated distinctly; and (2) showers contained in one group show an anisotropy of arrival direction
Relocation of active acetylcholinesterase to liposome-gel conjugate
ArticleJOURNAL OF COLLOID AND INTERFACE SCIENCE. 307(1): 296-299 (2007)journal articl
Vortex structure in spinor F=2 Bose-Einstein condensates
Extended Gross-Pitaevskii equations for the rotating F=2 condensate in a
harmonic trap are solved both numerically and variationally using trial
functions for each component of the wave function. Axially-symmetric vortex
solutions are analyzed and energies of polar and cyclic states are calculated.
The equilibrium transitions between different phases with changing of the
magnetization are studied. We show that at high magnetization the ground state
of the system is determined by interaction in "density" channel, and at low
magnetization spin interactions play a dominant role. Although there are five
hyperfine states, all the particles are always condensed in one, two or three
states. Two novel types of vortex structures are also discussed.Comment: 6 pages, 3 figure
Immobilization of liposomes on hydrophobically modified polymer gel particles in batch mode interaction
ArticleCOLLOIDS AND SURFACES B-BIOINTERFACES. 55(2): 235-240 (2007)journal articl
Larkin-Ovchinnikov-Fulde-Ferrell phase in the superconductor (TMTSF)2ClO4: Theory versus experiment
We consider a formation of the Larkin-Ovchinnikov-Fulde-Ferrell (LOFF) phase
in a quasi-one-dimensional (Q1D) conductor in a magnetic field, parallel to its
conducting chains, where we take into account both the paramagnetic
spin-splitting and orbital destructive effects against superconductivity. We
show that, due to a relative weakness of the orbital effects in a Q1D case, the
LOFF phase appears in (TMTSF)ClO superconductor for real values of its
Q1D band parameters. We compare our theoretical calculations with the recent
experimental data by Y. Maeno's group [S. Yonezawa et al., Phys. Rev. Lett.
\textbf{100}, 117002 (2008)] and show that there is a good qualitative and
quantitative agreement between the theory and experimental data.Comment: 4 pages, 1 figur
Collective Oscillations of Vortex Lattices in Rotating Bose-Einstein Condensates
The complete low-energy collective-excitation spectrum of vortex lattices is
discussed for rotating Bose-Einstein condensates (BEC) by solving the
Bogoliubov-de Gennes (BdG) equation, yielding, e.g., the Tkachenko mode
recently observed at JILA. The totally symmetric subset of these modes includes
the transverse shear, common longitudinal, and differential longitudinal modes.
We also solve the time-dependent Gross-Pitaevskii (TDGP) equation to simulate
the actual JILA experiment, obtaining the Tkachenko mode and identifying a pair
of breathing modes. Combining both the BdG and TDGP approaches allows one to
unambiguously identify every observed mode.Comment: 5 pages, 4 figure
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