Benign ovarian cysts and breast cancer risk

Benign ovarian cysts have been suggested to influence breast cancer risk. To provide a comprehensive picture of the relation between ovarian cysts and breast cancer, we analyzed the data of 3 case-control studies conducted in northern Italy and the Swiss Canton of Vaud between 1983 and 2001. These studies included 6,315 incident, histologically confirmed breast cancer cases and 6,038 hospital-based controls. Odds ratios (OR) and the corresponding 95% confidence intervals (CI) were estimated using unconditional multiple logistic regression models, including terms for sociodemographic, menstrual and reproductive factors. Overall, 4.9% of breast cancer cases and 6.6% of controls reported a history of ovarian cysts, with a multivariate OR of 0.72 (95% CI 0.62-0.85). The inverse association between ovarian cysts and breast cancer was consistent in separate strata of age at menarche, parity, age at menopause status and family history of breast cancer. No meaningful differences were also found across strata of menstrual cycle length, oral contraceptive use, history of oophorectomy and body mass index. Thus, the inverse relation between ovarian cysts and breast cancer risk was not accounted for by earlier menopause, or by any difference in reproductive and menstrual characteristics. Although some hormonal correlates of ovarian cysts may have a role on breast cancer risk, a biological explanation of this inverse association is still unclear. [Ed.]]]> Breast Neoplasms; Ovarian Cysts eng oai:serval.unil.ch:BIB_60E7401120E0 2022-05-07T01:19:00Z openaire documents urnserval <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_60E7401120E0 Peroxisome proliferator-activated receptor beta regulates acyl-CoA synthetase 2 in reaggregated rat brain cell cultures. info:doi:10.1074/jbc.274.50.35881 info:eu-repo/semantics/altIdentifier/doi/10.1074/jbc.274.50.35881 info:eu-repo/semantics/altIdentifier/pmid/10585473 Basu-Modak, S. Braissant, O. Escher, P. Desvergne, B. Honegger, P. Wahli, W. info:eu-repo/semantics/article article 1999 Journal of Biological Chemistry, vol. 274, no. 50, pp. 35881-35888 info:eu-repo/semantics/altIdentifier/pissn/0021-9258[print], 0021-9258[linking] <![CDATA[Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that regulate the expression of many genes involved in lipid metabolism. The biological roles of PPARalpha and PPARgamma are relatively well understood, but little is known about the function of PPARbeta. To address this question, and because PPARbeta is expressed to a high level in the developing brain, we used reaggregated brain cell cultures prepared from dissociated fetal rat telencephalon as experimental model. In these primary cultures, the fetal cells initially form random aggregates, which progressively acquire a tissue-specific pattern resembling that of the brain. PPARs are differentially expressed in these aggregates, with PPARbeta being the prevalent isotype. PPARalpha is present at a very low level, and PPARgamma is absent. Cell type-specific expression analyses revealed that PPARbeta is ubiquitous and most abundant in some neurons, whereas PPARalpha is predominantly astrocytic. We chose acyl-CoA synthetases (ACSs) 1, 2, and 3 as potential target genes of PPARbeta and first analyzed their temporal and cell type-specific pattern. This analysis indicated that ACS2 and PPARbeta mRNAs have overlapping expression patterns, thus designating the ACS2 gene as a putative target of PPARbeta. Using a selective PPARbeta activator, we found that the ACS2 gene is transcriptionally regulated by PPARbeta, demonstrating a role for PPARbeta in brain lipid metabolism

Trends in laryngeal cancer mortality in Europe

After a steady increase since the 1950s, laryngeal cancer mortality had tended to level off since the early 1980s in men from most European countries. To update trends in laryngeal cancer mortality in Europe, age-standardized (world standard) mortality rates per 100,000 were derived from the WHO mortality database for 33 European countries over the period 1980-2001. Jointpoint analysis was used to identify significant changes in mortality rates. In the European Union (EU) as a whole, male mortality declined by 0.8% per year between 1980 and 1989, by 2.8% between 1989 and 1995, by 5.3% between 1995 and 1998, and by 1.5% thereafter (rates were 5.1/100,000 in 1980-1981 and 3.3/100,000 in 2000-2001). This mainly reflects a decrease in rates in men from western and southern European countries, which had exceedingly high rates in the past. Male laryngeal mortality rose up to the early 1990s, and leveled off thereafter in several countries from central and eastern Europe. In 2000-2001 there was still a 10-15-fold variation in male laryngeal mortality between the highest rates in Croatia (7.9/100,000) and Hungary (7.7/100,000) and the lowest ones in Sweden (0.5/100,000) and Finland (0.8/100,000). Laryngeal cancer mortality was comparatively low in women from most European countries, with stable rates around 0.3/100,000 in the EU as a whole over the last 2 decades. Laryngeal cancer trends should be interpreted in terms of patterns and changes in exposure to alcohol and tobacco. Despite recent declines, the persistence of a wide variability in male laryngeal cancer mortality indicates that there is still ample scope for prevention of laryngeal cancer in Europe. [Ed.]]]> Laryngeal Neoplasms; Mortality eng oai:serval.unil.ch:BIB_E23DFD6660FA 2022-05-07T01:28:48Z openaire documents urnserval <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_E23DFD6660FA Why is there philosophy in India? Johannes, Bronkhorst Johannes, Bronkhorst (ed.) info:eu-repo/semantics/book book 1999 Indian philosophy, Indian history eng https://serval.unil.ch/resource/serval:BIB_E23DFD6660FA.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_E23DFD6660FA3 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_E23DFD6660FA3 info:eu-repo/semantics/submittedVersion info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer application/pdf oai:serval.unil.ch:BIB_E23E086D3432 2022-05-07T01:28:48Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_E23E086D3432 Compte-rendu : « Gwénola Réto, La bienveillance à l’école » https://halshs.archives-ouvertes.fr/halshs-03452642 Camille, Roelens info:eu-repo/semantics/article article 2021 Le Télémaque. Philosophie, Education, Société, no. 60 fre oai:serval.unil.ch:BIB_E23F61C3E477 2022-05-07T01:28:48Z openaire documents urnserval <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_E23F61C3E477 Bioterrorism: myth or reality? info:doi:10.1111/1469-0691.12713 info:eu-repo/semantics/altIdentifier/doi/10.1111/1469-0691.12713 info:eu-repo/semantics/altIdentifier/pmid/24920295 Greub, G. Grobusch, M.P. info:eu-repo/semantics/article article 2014 Clinical Microbiology and Infection, vol. 20, no. 6, pp. 485-487 info:eu-repo/semantics/altIdentifier/eissn/1469-0691 urn:issn:1198-743X eng https://serval.unil.ch/resource/serval:BIB_E23F61C3E477.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_E23F61C3E4776 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_E23F61C3E4776 info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/restrictedAccess Restricted: indefinite embargo Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer application/pdf oai:serval.unil.ch:BIB_E24085AADE3D 2022-05-07T01:28:48Z openaire documents <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_E24085AADE3D De la communauté à l’utopie : l’impact sociopolitique des théâtres postdramatiques https://www.fabula.org/revue/document12988.php Aurélien, Maignant info:eu-repo/semantics/article article 2020-06-01 Acta Fabula, vol. 6, no. 21 info:eu-repo/semantics/altIdentifier/pissn/1496-9610 fre https://serval.unil.ch/resource/serval:BIB_E24085AADE3D.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_E24085AADE3D7 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_E24085AADE3D7 info:eu-repo/semantics/acceptedVersion info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer application/pdf oai:serval.unil.ch:BIB_E24153DBE7DF 2022-05-07T01:28:48Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_E24153DBE7DF Assurance maladie et dépenses de santé : présentation Mougeot, Michel info:eu-repo/semantics/article article 2000 Revue d'économie politique, vol. 110, no. 4, pp. 447-456 info:eu-repo/semantics/altIdentifier/pissn/0373-2630 oai:serval.unil.ch:BIB_E241922E4472 2022-05-07T01:28:48Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_E241922E4472 Energy expenditure and whole body protein synthesis in very low birth weight (VLBW) infants info:eu-repo/semantics/altIdentifier/pmid/6580179 Schutz, Y. Catzeflis, C. Gudinchet, F. Micheli, J. Welsch, C. Arnaud, M. J. Jequier, E. info:eu-repo/semantics/article article 1983 Experientia Suppl, vol. 44, pp. 45-56 info:eu-repo/semantics/altIdentifier/pissn/0071-335X <![CDATA[To examine the rates of whole body protein synthesis and energy expenditure during the rapid growing period, premature infants of very low birth weight (VLBW) (less than 1500 g), appropriate for gestational age were kept under standard thermoneutrality conditions and received a formula diet providing 110 kcal/kg.d metabolisable energy (ME) and 3.3 g protein/kg.d. Their energy expenditure was measured by open circuit indirect calorimetry. Nitrogen turnover and whole body protein synthesis and catabolism were determined using repeated oral administration of 15N-glycine for 60-72 h followed by the analysis of 15N-enrichment in urinary urea. These VLBW infants grew at an average rate of 15 g/kg.d. About half of the ME intake (i.e. 50 kcal/kg.d) was invested in weight gain while the remainder (i.e. 60 kcal/kg.d) was oxidised. The energy equivalent of the weight gain (i.e. the amount of energy stored per g weight gain) and the N balance indicated that lean tissue made up approximately 2/3 of the weight gained and fat tissue the remaining 1/3. The plateau value for 15N enrichment reached on the third day of administration allowed us to calculate a rate of protein synthesis of 14 g/kg.d and protein breakdown of 12 g/kg.d in five VLBW fed a formula diet. The elevated energy expenditure of the very low birth weight infant seems to be related to its rapid rate of weight gain which is accompanied by a high rate of body protein synthesis. More than 20% of the total energy expenditure of the VLBW infants was accounted for by whole body protein synthesis

Mediterranean Diet and Breast Cancer Risk

Abstract: The Mediterranean diet has been related to a reduced risk of several common cancers but its role on breast cancer has not been quantified yet. We investigated the association between adherence to the Mediterranean diet and breast cancer risk by means of a hospital-based case-control study conducted in Italy and Switzerland. 3034 breast cancer cases and 3392 controls admitted to the same network of hospitals for acute, non-neoplastic and non-gynaecologic diseases were studied. Adherence to the Mediterranean diet was quantitatively measured through a Mediterranean Diet Score (MDS), summarizing the major characteristics of the Mediterranean dietary pattern and ranging from 0 (lowest adherence) to 9 (highest adherence). We estimated the odds ratios (ORs) of breast cancer for the MDS using multiple logistic regression models, adjusting for several covariates. Compared to a MDS of 0–3, the ORs for breast cancer were 0.86 (95% confidence interval, CI, 0.76–0.98) for a MDS of 4–5 and 0.82 (95% CI, 0.71–0.95) for a MDS of 6–9 (p for trend = 0.008). The exclusion of the ethanol component from the MDS did not materially modify the ORs (e.g., OR = 0.81, 95% CI, 0.70–0.95, for MDS ≥ 6). Results were similar in pre- and post-menopausal women. Adherence to the Mediterranean diet was associated with a reduced breast cancer risk

Fried foods, olive oil and colorectal cancer

BACKGROUND: The epidemiologic evidence for an etiologic role of fried foods and heterocyclic amines in colorectal carcinogenesis is inconsistent. PATIENTS AND METHODS: We have investigated the relation between fried foods and colorectal cancer risk using data from a large, multicentric case-control study conducted in Italy and Switzerland between 1992 and 2000, with 1394 cases of colon cancer, 886 cases of rectal cancer and 4765 controls. RESULTS: After allowing for major relevant covariates, the multivariate odds ratios (ORs) for an increment of one portion per week of fried foods were 0.97 [95% confidence interval (CI) = 0.93-1.01] for colon cancer and 1.04 (95% CI = 1.00-1.09) for rectal cancer. When we analyzed the type of fats mainly used for frying, we found that olive oil, but not other types of oils, appeared to protect from colon cancer risk (OR = 0.89, 95% CI = 0.82-0.98). CONCLUSIONS: Our results do not indicate a relevant role of fried foods on colorectal cancer risk. We found a possible favorable effect of (fried) olive oil on colon cancer risk but not on rectal cancer risk. [Authors]]]> Colonic Neoplasms ; Cookery ; Dietary Fats ; Food ; Plant Oils ; Rectal Neoplasms eng https://serval.unil.ch/resource/serval:BIB_CE97D8453D33.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_CE97D8453D338 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_CE97D8453D338 info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer application/pdf oai:serval.unil.ch:BIB_CE97E075B266 2022-05-07T01:27:21Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_CE97E075B266 A direct pathway from thalamus to visual callosal neurons in cat info:eu-repo/semantics/altIdentifier/pmid/7351225 Hornung, J. P. Garey, L. J. info:eu-repo/semantics/article article 1980 Experimental Brain Research, vol. 38, no. 1, pp. 121-3 info:eu-repo/semantics/altIdentifier/pissn/0014-4819 <![CDATA[Horseradish peroxidase was injected in the right visual cortex and a large electrolytic lesion made in the left lateral geniculate nucleus of an adult cat. Neurons of origin of the callosal projection to the injected cortex were identified by retrograde labelling and selected for electron microscopic study. Degenerating thalamo-cortical axon terminals were found to contact a labelled stellate cell in layer IV and a labelled pyramidal cell in layer III at the border region of areas 17 and 18. We conclude that there is a monosynaptic pathway from lateral geniculate nucleus to the cells of origin of callosal axons to the contralateral visual cortex

Une politique impériale du consensus : G. Cresci-Markone, Ecumene Augustea, Una politica per il consenso

Levi Mario-Attilio. Une politique impériale du consensus : G. Cresci-Markone, Ecumene Augustea, Una politica per il consenso. In: Dialogues d'histoire ancienne, vol. 19, n°2, 1993. pp. 407-408

II mondo di Delfi

Levi Mario-Attilio. II mondo di Delfi. In: Mélanges Pierre Lévêque. Tome 1 : Religion. Besançon : Université de Franche-Comté, 1988. pp. 219-228. (Annales littéraires de l'Université de Besançon, 367

Inizi di Scipione Africano e di una età di cambiamento

II riconoscimento di un rapporte privilegiato fra una grande regione periferica del Mediterraneo, la Spagna, e la casata dei Cornelii Scipioni, e con il comando avuto dal giovane Scipione, il futuro Africano, per succedere allo zio e al padre, morti in combattimento su quel fronte a un mese di distanza l'uno dall'altro, ha inizio la lunga série di trasgressioni aile regole magistratuali della repubblica senatoria. In più, si comincia anche ad ammettere la possibilità di comandi affidati "ad hominem" senza corrispondente magistratura, cioé la figura del "privatus cum imperio". Si tratta di un dclo che, in quattro secoli di evoluzione, portò alla monarchia assoluta, che tuttavia solo con Adriano si riconobbe tale, senza compromessi né infingimenti.La reconnaissance d'un rapport privilégié entre une grande région périphérique de la Méditerranée, l'Espagne, et les Cornelii Scipion, et avec le commandement obtenu par le jeune Scipion, le futur Africain, qui succède ainsi à son oncle et à son père, morts au combat sur ce front-là à un mois de distance l'un de l'autre, ouvre la longue série des transgressions aux règles concernant les magistratures de la république sénatoriale. De plus, on commence aussi à admettre qu'il est possible de confier des commandements "ad hominem" sans une magistrature correspondante, c'est- à-dire qu'on accepte la figure du "privatus cum imperio". Il s'agit d'un cycle qui, au cours d'une évolution de quatre siècles, a conduit à la monarchie absolue, qui cependant ne se reconnaît comme telle, sans compromissions ni dissimulations, qu'avec Hadrien.Levi Mario-Attilio. Inizi di Scipione Africano e di una età di cambiamento. In: Dialogues d'histoire ancienne, vol. 23, n°1, 1997. pp. 145-153

Nobilis e nobilitas

The adjective nobilis and the abstract noun nobilitas deriving from it refer neither to social class nor to a status of public law but, according to their original and etymological meaning, to the notoriety that the Roman citizen acquires thanks to his prestige and properties.L'adjectif nobilis et le nom abstrait dérivé nobilitas, loin de désigner une catégorie sociale ou bien un status de droit public, indiquent, à l'origine et en accord avec leur acception étymologique, la notoriété personnelle acquise par le citoyen romain grâce à son prestige ou à ses richesses.Levi Mario-Attilio. Nobilis e nobilitas. In: Revue des Études Anciennes. Tome 100, 1998, n°3-4. Centenaire de la revue. pp. 555-559

Au sujet des laoi et des inscriptions de Mnesimachos

Levi Mario-Attilio. Au sujet des laoi et des inscriptions de Mnesimachos. In: Actes du colloque 1973 sur l'esclavage. Besançon 2-3 mai 1973. Besançon : Presses Universitaires de Franche-Comté, 1976. pp. 257-279. (Actes des colloques du Groupe de recherche sur l'esclavage dans l'antiquité, 4