A Chandra Survey of the X-ray Properties of Broad Absorption Line Radio-Loud Quasars

This work presents the results of a Chandra study of 21 broad absorption line (BAL) radio-loud quasars (RLQs). We conducted a Chandra snapshot survey of 12 bright BAL RLQs selected from SDSS/FIRST data and possessing a wide range of radio and CIV absorption properties. Optical spectra were obtained nearly contemporaneously with the Hobby-Eberly Telescope; no strong flux or BAL variability was seen between epochs. We also include in our sample 9 additional BAL RLQs possessing archival Chandra coverage. We compare the properties of (predominantly high-ionization) BAL RLQs to those of non-BAL RLQs as well as to BAL radio-quiet quasars (RQQs) and non-BAL RQQs for context. All 12 snapshot and 8/9 archival BAL RLQs are detected, with observed X-ray luminosities less than those of non-BAL RLQs having comparable optical/UV luminosities by typical factors of 4.1-8.5. (BAL RLQs are also X-ray weak by typical factors of 2.0-4.5 relative to non-BAL RLQs having both comparable optical/UV and radio luminosities.) However, BAL RLQs are not as X-ray weak relative to non-BAL RLQs as are BAL RQQs relative to non-BAL RQQs. While some BAL RLQs have harder X-ray spectra than typical non-BAL RLQs, some have hardness ratios consistent with those of non-BAL RLQs, and there does not appear to be a correlation between X-ray weakness and spectral hardness, in contrast to the situation for BAL RQQs. RLQs are expected to have X-ray continuum contributions from both disk-corona and small-scale jet emission. While the entire X-ray continuum in BAL RLQs cannot be obscured to the same degree as in BAL RQQs, we calculate that the jet is likely partially covered in many BAL RLQs. We comment briefly on implications for geometries and source ages in BAL RLQs.Comment: 48 pages, 5 tables, 14 figures, accepted by Ap

Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties

Reduced NO levels due to the deficiency of tetrahydrobiopterin (BH4) contribute to impaired vasodilation in pulmonary hypertension Due to the chemically unstable nature of BH4 it was hypothesised that oxidatively stable analogues of BR, would be able to support NO synthesis to improve Endothelial dysfunction in pulmonary hypertension Two analogues of BH4 namely 6-hydroxymethyl pterin (HMP) and 6-acetyl 7 7-dimethyl 7 8-dihydropterin (ADDP) were evaluated for vasodilator activity on precontracted rat pulmonary artery rings ADDP was administered to pulmonary hypertensive rats followed by measurement of pulmonary vascular resistance in perfused lungs and eNOS expression by immunohistochemistry ADDP and HMP caused significant relaxation in vitro in rat pulmonary arteries depleted of BH4 with a maximum relaxation at 0 3 mu M (both P<005) Vasodilator activity of ADDP and HMP was completely abolished following preincubation with the NO synthase inhibitor L-NAME ADDP and HMP did not alter relaxation induced by carbachol or spermine NONOate BH4 Itself did not produce relaxation In rats receiving ADDP 141 mg/kg/day pulmonary vasodilation induced by calcium ionophore A23187 was augmented and eNOS immunoreactivity was increased In conclusion ADDP and HMP are two analogues of BH4 which can act as oxidatively stable alternatives to BH4 in causing NO-mediated vasorelaxation Chronic treatment with ADDP resulted in Improvement of NO-mediated pulmonary artery dilation and enhanced expression of eNOS in the pulmonary vascular endothelium Chemically stable analogue, of BH4 may be able to limit endothelial dysfunction in the pulmonary vasculatur

X-raying the Winds of Luminous Active Galaxies

We briefly describe some recent observational results, mainly at X-ray wavelengths, on the winds of luminous active galactic nuclei (AGNs). These winds likely play a significant role in galaxy feedback. Topics covered include (1) Relations between X-ray and UV absorption in Broad Absorption Line (BAL) and mini-BAL quasars; (2) X-ray absorption in radio-loud BAL quasars; and (3) Evidence for relativistic iron K BALs in the X-ray spectra of a few bright quasars. We also mention some key outstanding problems and prospects for future advances; e.g., with the International X-ray Observatory (IXO).Comment: 7 pages, 3 figures, to appear in proceedings of the conference "The Monster's Fiery Breath: Feedback in Galaxies, Groups, and Clusters", June 2009, Madison, Wisconsi

Portable dynamic fundus instrument

A portable diagnostic image analysis instrument is disclosed for retinal funduscopy in which an eye fundus image is optically processed by a lens system to a charge coupled device (CCD) which produces recordable and viewable output data and is simultaneously viewable on an electronic view finder. The fundus image is processed to develop a representation of the vessel or vessels from the output data

Model Dependence of the 2H Electric Dipole Moment

Background: Direct measurement of the electric dipole moment (EDM) of the neutron lies in the future; measurement of a nuclear EDM may well come first. The deuteron is one nucleus for which exact model calculations are feasible. Purpose: We explore the model dependence of deuteron EDM calculations. Methods: Using a separable potential formulation of the Hamiltonian, we examine the sensitivity of the deuteron EDM to variation in the nucleon-nucleon interaction. We write the EDM as the sum of two terms, the first depending on the target wave function with plane-wave intermediate states, and the second depending on intermediate multiple scattering in the 3P1 channel, the latter being sensitive to the off-shell behavior of the 3P1 amplitude. Results: We compare the full calculation with the plane-wave approximation result, examine the tensor force contribution to the model results, and explore the effect of short range repulsion found in realistic, contemporary potential models of the deuteron. Conclusions: Because one-pion exchange dominates the EDM calculation, separable potential model calculations will provide an adequate description of the 2H EDM until such time as a better than 10% measurement is obtained.Comment: 21 pages, 2 figures, submitted to Physical Review

A comparison of cortical and trabecular bone from C57 Black 6 mice using Raman spectroscopy

Peer reviewedPostprin

Broad Absorption Line Variability in Radio-Loud Quasars

We investigate C IV broad absorption line (BAL) variability within a sample of 46 radio-loud quasars (RLQs), selected from SDSS/FIRST data to include both core-dominated (39) and lobe-dominated (7) objects. The sample consists primarily of high-ionization BAL quasars, and a substantial fraction have large BAL velocities or equivalent widths; their radio luminosities and radio-loudness values span ~2.5 orders of magnitude. We have obtained 34 new Hobby-Eberly Telescope (HET) spectra of 28 BAL RLQs to compare to earlier SDSS data, and we also incorporate archival coverage (primarily dual-epoch SDSS) for a total set of 78 pairs of equivalent width measurements for 46 BAL RLQs, probing rest-frame timescales of ~80-6000 d (median 500 d). In general, only modest changes in the depths of segments of absorption troughs are observed, akin to those seen in prior studies of BAL RQQs. Also similar to previous findings for RQQs, the RLQs studied here are more likely to display BAL variability on longer rest-frame timescales. However, typical values of |Delta_EW| and |Delta_EW|/ are about 40+/-20% lower for BAL RLQs when compared with those of a timescale-matched sample of BAL RQQs. Optical continuum variability is of similar amplitude in BAL RLQs and BAL RQQs; for both RLQs and RQQs, continuum variability tends to be stronger on longer timescales. BAL variability in RLQs does not obviously depend upon their radio luminosities or radio-loudness values, but we do find tentative evidence for greater fractional BAL variability within lobe-dominated RLQs. Enhanced BAL variability within more edge-on (lobe-dominated) RLQs supports some geometrical dependence to the outflow structure.Comment: 27 pages, 16 figures, 6 tables, accepted to MNRAS, full Appendix A at http://www.macalester.edu/~bmille13/balrlqs.htm

Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo.

Extracts from BSC-40 cells infected with vaccinia recombinants expressing either the yeast KEX2 prohormone endoprotease or a human structural homologue (fur gene product) contained an elevated level of a membrane-associated endoproteolytic activity that could cleave at pairs of basic amino acids (-LysArg- and -ArgArg-). The fur-directed activity (furin) shared many properties with Kex2p including activity at pH 7.3 and a requirement for calcium. By using antifurin antibodies, immunoblot analysis detected two furin translation products (90 and 96 kD), while immunofluorescence indicated localization to the Golgi apparatus. Coexpression of either Kex2p or furin with the mouse beta-nerve growth factor precursor (pro-beta-NGF) resulted in greatly enhanced conversion of the precursor to mature nerve growth factor. Thus, the sequence homology shared by furin and the yeast KEX2 prohormone processing enzyme is reflected by significant functional homology both in vitro and in vivo