Impacts of osteoporosis on quality of life in elderly women

BACKGROUND: Osteoporosis, the most common pathological cause of skeletal weakening and the most common metabolic bone disease, is caused by loss of bone mass density (BMD). Fractures due to osteoporosis will worsen life, increase pain, and decrease quality of life. The present study aimed to determine the impact of osteoporosis on quality of life among elderly women. METHODS: In a cross-sectional study, 275 postmenopausal women (age: 50-70 years) who were referred to the Namazi Hospital (Shiraz, Iran) were included. BMD was measured according to the World Health Organization (WHO) standards. Women with BMD < -2.5 standard deviation (SD) of the average value in young adults were defined as osteoporosis cases. Women with BMD > 1 SD of the average value were defined as normal cases. Quality of life was measured by Qualeffo-41 Questionnaire and reported on a scale of 100. Data was analyzed in SPSS and P values less than 0.05 were considered significant. RESULTS: The mean quality of life score was 25.5 ± 11.7. According to the definition by the WHO, 70.2% of the participants were affected with osteoporosis. Only 22.3% of osteoporotic women and 30.5% of normal subjects had good quality of life. A significant statistical difference was observed between osteoporotic and normal postmenopausal women in social activities. Overweight and low education were predictors of poor quality of life in multivariate analysis. CONCLUSION: The imposed financial burden and complications of osteoporosis can affect the patients’ quality of life. Health education regarding nutritional behaviors and social activities at adolescence are helpful interventions for decreasing the prevalence of the disease. Since osteoporosis has a gradual, outward, and asymptomatic trend, more attention needs to be paid to preventive and screening programs

Fibroblast growth factor-23 in patients with systemic sclerosis: A case–control study

AbstractBackgroundFibroblast growth factor-23 (FGF-23) is actively involved in phosphate homeostasis and skeletogenesis.Aim of the workTo assess the serum level of FGF-23 in systemic sclerosis (SSc) patients (both diffuse dSSc and limited lSSc subtypes) in order to find if it has a role in the pathogenesis of the disease and study its relation to the clinical manifestations.Patients and methodsThe study included 30 dSSc patients, 30 lSSc and 28 age and sex matched controls. In patients, clinical examination and laboratory investigations were performed and Medsger severity scale assessed. Serum FGF-23 was measured using ELISA.ResultsThe age of dSSc patients was 36.94±9.89years and the lSSc 38.36±10.04years. The serum FGF-23 level was 23.44±14.86pg/ml in dSSc patients, 20.01±13.92pg/ml in lSSc patients and 23.09±11.45pg/ml in the control (p=0.58). No significant difference in the FGF-23 level was found according to the presence of lung fibrosis (p=0.6). There was no significant difference in FGF levels among patients according to the severity (p=0.39). In SSc patients there was a significant correlation between FGF and serum phosphorus especially in dSSc patients (r=0.6, p=0.003). Serum urea significantly correlated with FGF-23 in those with dSSc (r=0.46, p=0.037). There was no significant difference in the FGF-23 levels (p=0.18) between those with a normal and impaired glomerular filtration rate.ConclusionThe mean serum level of FGF-23 in this study showed no significant difference between systemic sclerosis patients and their subtypes with the normal subjects. It seems to have no role in the clinical manifestations of the disease

Impacts of osteoporosis on quality of life in elderly women

BACKGROUND: Osteoporosis, the most common pathological cause of skeletal weakening and the most common metabolic bone disease, is caused by loss of bone mass density (BMD). Fractures due to osteoporosis will worsen life, increase pain, and decrease quality of life. The present study aimed to determine the impact of osteoporosis on quality of life among elderly women. METHODS: In a cross-sectional study, 275 postmenopausal women (age: 50-70 years) who were referred to the Namazi Hospital (Shiraz, Iran) were included. BMD was measured according to the World Health Organization (WHO) standards. Women with BMD 1 SD of the average value were defined as normal cases. Quality of life was measured by Qualeffo-41 Questionnaire and reported on a scale of 100. Data was analyzed in SPSS and P values less than 0.05 were considered significant. RESULTS: The mean quality of life score was 25.5 ± 11.7. According to the definition by the WHO, 70.2% of the participants were affected with osteoporosis. Only 22.3% of osteoporotic women and 30.5% of normal subjects had good quality of life. A significant statistical difference was observed between osteoporotic and normal postmenopausal women in social activities. Overweight and low education were predictors of poor quality of life in multivariate analysis. CONCLUSION: The imposed financial burden and complications of osteoporosis can affect the patients’ quality of life. Health education regarding nutritional behaviors and social activities at adolescence are helpful interventions for decreasing the prevalence of the disease. Since osteoporosis has a gradual, outward, and asymptomatic trend, more attention needs to be paid to preventive and screening programs

Iranian Multicenter Osteoporosis Studies (IMOS) during last decade : rationale, main findings, lessons learned and the way forward

Purpose Osteoporosis remains a major public health concern, considering its high prevalence along with its association with osteoporotic fractures. It imposes a heavy burden on the society worldwide as the population ages. This paper aims to provide a brief review on Iranian multicenter osteoporosis studies (IMOS) studies and provide some recommendations for improvement. Methods IMOS studies were conducted to investigate the prevalence of osteoporosis and related risk factors. This paper provides a general view on the Iranian multicenter osteoporosis studies (IMOS), conducted during last decades. Results The results showed a high prevalence of osteoporosis and vitamin D deficiency in the Iranian population. Although the study protocols were mainly similar, some differences were observed in terms of the study population and design. The protocol of IMOS-3 was modified to overcome the setbacks noted in the previous studies; however, it was implemented in two cities with noticeably different socioeconomic and geographical characteristics from five cities where the first phase was conducted, resulting in different lifestyles and habits. Although previous IMOS studies have raised major concerns regarding the high prevalence of osteoporosis and vitamin D deficiency, interpretation should be made with caution given the differences, especially in the surveyed cities. Such discrepancies cause problems in trend analysis, and nationally representative samplings are preferably needed to correctly compare the prevalence of osteoporosis and related risk factors. Conclusions Considering the aging population and the importance of osteoporosis and its complication, developing a standard surveillance system to obtain valid and nationally representative estimates is recommended

prevalence of dyslipidemia in healthy children of kavar, fars province

Background: lipid profile disorders are important in children because they plays an important role in future cardiovascular atherosclerotic disorders. Lack of sufficient data in this regard in Fars province was the reason of performing this study. Methods: 500 healthy children were gathered from Kavar schools with systematic randomized method sampling. Body measurements and lipid profile were checked with standard methods. Data were analyzed by SPSS software. Results: We find that 35% of children have at least one abnormal lipid profile tests. 34.7% had low HDL, 7% had high total cholesterol, 13.6% had high triglyceride and 10.6% had high non HDL cholesterol. Among these abnormalities, high total and high non HDL cholesterol were more prevalent in girls. The most associated factors were body weight, height and waist circumference. Conclusion: 35% of children have at least one abnormal lipid profile tests and cholesterol disorders were more prevalent in girls. We suggest early screening, early diagnosis and treatment of these abnormalities in children which need prevention of risk factors such as obesity and inactivity

Association between Metabolic Syndrome Criteria and Body-composition Components in Children with Type 1 Diabetes Mellitus

Background Metabolic syndrome (MES) consists of central obesity, hypertension, reduced high density lipoprotein (HDL), elevated serum triglycerides and high Fasting blood sugar (FBS). They are susceptible to cardio-vascular disease, and insulin resistance. The goal of present research was to assess any relation between the composition of the body in Type 1 Diabetes Mellitus (T1DM) children and having components of metabolic syndrome. Materials and Methods This cross sectional study included all T1DM children who were referred to the pediatric clinic of diabetes, affiliated to the Shiraz University of Medical Sciences, Iran during Jul 2013 to Aug 2014. Anthropometric data, blood pressure, fasting blood glucose, lipids and body mass indices like android and gynoid fat mass was done by one physician with standard scale and techniques. The obtained data were analyzed using SPSS-18. Results Overall 87cases with definite diagnosis of T1DM were admitted in this duration (2013-2014).There was a positive correlation appeared between hypertriglyceridemia and Android fat mass (r=0.1 and P =0.046).  Otherwise, there wasn’t any relation between body composition criteria and the reduced HDL level, high blood pressure, Abdominal obesity and elevated FBS (P>0.05) . Conclusion It was revealed that hypertriglyceridemia was associated with Android fat mass. However, more pathophysiological research is needed to reveal the association of MES components and body-composition in T1DM children

Evaluation of the the metabolic syndrome criteria and body composition in ambulatory children with Epilepsy in southern Iran: a case – control study

Objectives:  Previous studies in adults with epilepsy revealed a higher prevalence of metabolic syndrome, which resulted in cerebrovascular and cardiovascular events, however, there is insufficient data about body composition and metabolic syndrome in children, especially in Middle Eastern region. We aim to Investigate metabolic syndrome criteria and body composition in ambulatory children with Epilepsy in Southern Iran. Material and Methods: 90 children aged 11.4 ± 3.2 years with epilepsy and their age- gender-matched controls were included in this study. Anthropometric data, lipid profile, blood sugar and blood pressure were checked. Body composition was evaluated using Hologic system dual – energy X-ray absorptiometry. Results: Prevalence of metabolic syndrome in patients (6.7%) was more than the controls (1.1%) (p-value = 0.043). Patients’ fat mass index was more than the controls (P = 0.012), and lean mass+ Bone Mineral Content (BMC) index lower than the controls (P = 0.017). Serum triglycerides in patients using carbamazepine was higher than the others (P = 0.019, Beta = 0.379). Blood pressure was higher in patients using carbamazepine (p = 0.016, Beta = -0.26). Fat mass index was higher in patients using sodium valproate (p = 0.031, Beta = 0.238).  Conclusion: Our study revealed that children with epilepsy are more prone to metabolic syndrome and higher body fat mass. Therefore, early diagnosis and prevention of metabolic syndrome criteria in patients with epilepsy, performing regular exercise and having a healthy diet should be encouraged in these children

Polymorphism in LRP5 (rs556442) is associated with higher TG levels in Iranian children

Background: Wnt signalling/LRP5 is involved in adipogenesis by down-regulating adipogenic transcription factors. Therefore polymorphisms in components of this pathway may lead to metabolic disorders. Aim: This study tested the impact of LRP5 polymorphism on lipid profile in Iranian children. Methods: The study population was comprised of 9–18 year old children (125 boys, 137 girls). Total cholesterol (TC), High Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL), Non-HDL cholesterol and Triglyceride (TG) levels were checked. Body composition was measured by the Hologic system DXA. PCR/restriction fragment length polymorphism (RFLP) was done for LRP5 (rs556442) genotyping. Multiple association analyses for TG level and genotype frequencies were assessed using logistic regression analysis, with adjustment for age, sex, BMI and puberty. Results: The results revealed that LRP5 (rs556442) had a significant influence on TG levels in unadjusted analysis and when adjusted for interacting factors. Higher TG levels were observed in AA/AG genotype of rs566442 in comparison to GG genotype (OR = 2.028, 95% CI = 0.997–4.127, p =  0.049). Conclusion: It is concluded that allele A has an important impact on increasing TG level in LRP5 in the studied population