Genetique moleculaire d'evenements controlant les modalites de la reproduction chez les plantes

SIGLECNRS AR 13382 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Moderate influenza vaccine effectiveness against hospitalisation with A(H3N2) and A(H1N1) influenza in 2013\u201314: Results from the InNHOVE network

We conducted a multicentre test negative case control study to estimate the 2013\u201314 influenza vaccine effectiveness (IVE) against hospitalised laboratory confirmed influenza in 12 hospitals in France, Italy and Spain. We included all 6518 years hospitalised patients targeted by local influenza vaccination campaign reporting an influenza-like illness within 7 days before admission. We defined as cases patients RT-PCR positive for influenza and as controls those negative for all influenza virus. We used a logistic regression to calculate IVE adjusted for country, month of onset, chronic diseases and age. We included 104 A(H1N1)pdm09, 157 A(H3N2) cases and 585 controls. The adjusted IVE was 42.8% (95%CI: 6.3;65;0) against A(H1N1)pdm09. It was respectively 61.4% (95%CI: 121.9;85.4), 39.4% (95%CI: 1232.2;72.2) and 19.7% (95%CI:-148.1;74.0) among patients aged 18\u201364, 65\u201379 and 6580 years. The adjusted IVE against A(H3N2) was 38.1% (95%CI: 8.3;58.2) overall. It was respectively 7.8% (95%CI: 12145.3;65.4), 25.6% (95%CI: 1236.0;59.2) and 55.2% (95%CI: 15.4;76.3) among patients aged 18\u201364, 65\u201379 and 6580 years. These results suggest a moderate and age varying effectiveness of the 2013\u201314 influenza vaccine to prevent hospitalised laboratory-confirmed influenza. While vaccination remains the most effective prevention measure, developing more immunogenic influenza vaccines is needed to prevent severe outcomes among target groups