Ocimum basilicum L. (basil) presents pro-apoptotic activity in an Ehrlich’s experimental tumor murine model

ABSTRACT Purpose: This study aimed to evaluate the therapeutic effect of an ethanol extract of Ocimum basilicum L. (EEOb) aerial parts against Ehrlich’s experimental tumor (EET) in mice. Methods: Swiss mice were divided into two groups (control and treated; n = 6). On day 21, all mice were inoculated subcutaneously with 2 × 106 (0.05 mL) EET cells in the left paw for solid tumor development. This study lasted 28 days. Treatment began 24 hours after inoculation with EET. Measurements of dorsoplantar thickness were used to assess tumor growth. The paw pad was collected for histopathological analysis and stained using the argyrophilic nucleolar organizing regions (AgNOR) technique and immunohistochemistry for proliferating cell nuclear antigen, Bcl-2 and Bax. Results: The treatment of animals with EEOb at 100 mg/kg intraperitoneally was able to reduce the growth (Control = 3.7 ± 0.1 mm vs. EEOb = 5.7 ± 0.2 mm) and the number of AgNORs of solid Ehrlich tumor. The antitumor effect of EEOb was associated with the induction of apoptosis of tumoral cell, as suggested by the reduction of the content of Bcl-2 induced by extract. Conclusions: The study demonstrated that daily administration of EEOb is able to reduce the growth of EET by induce apoptosis of tumoral cells

Clinical and Epidemiological Profile of Cirrhotic Patients at a Reference Center in Belém-PA, Analysis of 10 years

Background: The aim of this study was to analyze the demographic, ethyological and clinical aspects of patients with liver cirrhosis treated in the Chronic Liver Disease Center. Methods: a descriptive, cross-sectional and retrospective study based on the analysis of 580 pacients’ medical records with the diagnosis of hepatic cirrhosis treated from 2004 to 2014 in Belém, Brazil. Conclusions: the profile was predominantly of male patients, aged between 51 and 60 years, coming from the capital ​​Belem, whose main etiologies of cirrhosis were C hepatitis and alcohol. Ascites was the most frequent clinical manifestation and Child-Pugh score A was the most prevalent

Evaluation Of Risk Factors In Cardiovascular Patients With Diagnosis Of Systemic Lupus Erythematosus (SLE)

Title: Evaluation of risk factors in cardiovascular patients with diagnosis of Systemic Lupus Erythematosus (SLE). Background: prevalence of cardiovascular risk factors in lupic patients.This study aimed to evaluate the presence of cardiovascular risk factors in patients diagnosed with SLE in a Rheumatology Ambulatory, comparing groups with and without SLE nephritis. Methods: a quantitative, observational and cross-sectional study was carried out during the period from November 2016 to June 2017. 86 patients were interviewed using specific protocol. Conclusions: among the cardiovascular risk factors evaluated, systemic hypertension was more frequent in SLE patients (33.7%), followed by smoking (17.4%) and diabetes mellitus (5.8%). There was, however, no difference between the frequency of these comorbidities in the groups with and without lupus nephritis

Zygmunt Bauman e a Modernidade Líquina

<p>Esse seminário tem como objetivo enfatizar a importância dos pensamentos de Zygmunt Bauman para o ensino no curso de graduação em enfermagem.</p&gt

Analysis of deaths occurred in households during the pandemic by COVID-19 in a Brazilian Amazon Region: an epidemiological approach

Universidade do Estado do Pará. Programa de Pós-Graduação em Biologia Parasitária na Amazônia. Belém, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Programa de Pós-Graduação em Epidemiologia e Vigilância em Saúde. Ananindeua, PA, Brasil.Secretaria de Saúde do Estado do Pará. Belém, PA, Brazil.Secretaria de Saúde do Estado do Pará. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Geoprocessamento. Ananindeua, PA, Brasil.Universidade do Estado do Pará. Programa de Pós-Graduação em Biologia Parasitária na Amazônia. Belém, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Programa de Pós-Graduação em Epidemiologia e Vigilância em Saúde. Ananindeua, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Programa de Pós-graduação em Pesquisa Clínica em Doenças Infecciosas. Rio de Janeiro, RJ, Brazil.Universidade Federal Rural da Amazônia. Belém, PA, Brazil.Universidade Federal Rural da Amazônia. Belém, PA, Brazil.Secretaria de Saúde do Estado do Pará. Belém, PA, Brazil.Universidade do Estado do Pará. Programa de Pós-Graduação em Biologia Parasitária na Amazônia. Belém, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.In the absence of an analysis of deaths at home from an epidemiological perspective, this study aims to analyze and describe the epidemiological profile of deaths at home assessed by the Death Ceremony Service (DCS) during the SARS-CoV-2 pandemic in the metropolitan region of the Brazilian Amazon, Belém do Pará. A descriptive, quantitative, secondary-based study based on the databases of the Mortality Information System (SIM), referring to the deaths that occurred from March 1 to March 27 June 2020. The variables worked were related to the profile and the causes in the death certificate. The causes of home deaths in 2019 were used to compare with 2020. In the indicated period, 1,203 deaths occurred, an increase of 454% in relation to 2019. The male gender (57.30%), the age group of 60+ (80.80%) and brown race (77.70%) were the most frequent. The main cause of death Acute myocardial infarction (15.05%) followed by COVID-19 (10.29%). During the pandemic, the majority of home deaths were not directly caused by COVID-19, however, they were influenced by it due to the need for social isolation, with the impossibility of obtaining the proper diagnosis or proper treatment, due to the impossibility of on-site care or lack of immediate response