1,748 research outputs found
ALPIDE for space applications: Power consumption
ALPIDE, a monolithic active pixel sensor developed for the ALIDE Inner Tracker upgrade, is studied as possible sensor unit for a space-borne particle tracker. The aspect of power consumption and heat dissipation is investigated
Acetaminophen administration in pediatric age: an observational prospective cross-sectional study
Background Parents often do not consider fever as an important physiological response and mechanism of defense against infections that leads to inappropriate use of antipyretics and potentially dangerous side effects. This study is designed to evaluate the appropriateness of antipyretics dosages generally administered to children with fever, and to identify factors that may influence dosage accuracy. Results In this cross-sectional study we analyzed the clinical records of 1397 children aged >1 month and 90 mg/kg/day of acetaminophen, the prescriber, the medication formula and the educational level of the caregiver who administered acetaminophen. Among those children included in our study, 74 % were administered acetaminophen for body temperature ≤ 38.4 °C. 24.12 % of children received >90 mg/kg/day of acetaminophen. Parents with university qualifications most commonly self-administered acetaminophen to their children, in a higher than standard dose. Self medication was also described in 60 % of children, whose acetaminophen was administered for temperatures < 38 °C. Acetaminophen over-dosage was also favored by the use of drug formulations as drops or syrup. Conclusions Our study shows that preventive action should be taken regarding the use of acetaminophen as antipyretic drug in children in order to reduce the fever phobia and self-prescription, especially of caregivers with higher educational levels. It is also necessary to promote a more appropriate use of acetaminophen in those parents using drops or syrup formulations
Operational experience, improvements, and performance of the CDF Run II silicon vertex detector
The Collider Detector at Fermilab (CDF) pursues a broad physics program at
Fermilab's Tevatron collider. Between Run II commissioning in early 2001 and
the end of operations in September 2011, the Tevatron delivered 12 fb-1 of
integrated luminosity of p-pbar collisions at sqrt(s)=1.96 TeV. Many physics
analyses undertaken by CDF require heavy flavor tagging with large charged
particle tracking acceptance. To realize these goals, in 2001 CDF installed
eight layers of silicon microstrip detectors around its interaction region.
These detectors were designed for 2--5 years of operation, radiation doses up
to 2 Mrad (0.02 Gy), and were expected to be replaced in 2004. The sensors were
not replaced, and the Tevatron run was extended for several years beyond its
design, exposing the sensors and electronics to much higher radiation doses
than anticipated. In this paper we describe the operational challenges
encountered over the past 10 years of running the CDF silicon detectors, the
preventive measures undertaken, and the improvements made along the way to
ensure their optimal performance for collecting high quality physics data. In
addition, we describe the quantities and methods used to monitor radiation
damage in the sensors for optimal performance and summarize the detector
performance quantities important to CDF's physics program, including vertex
resolution, heavy flavor tagging, and silicon vertex trigger performance.Comment: Preprint accepted for publication in Nuclear Instruments and Methods
A (07/31/2013
Prevalence of Fabry disease and GLA variants in young patients with acute stroke: the challenge to widen the screening. The Fabry-Stroke Italian Registry
Background: Fabry disease (FD) is a treatable X-linked lysosomal storage disorder caused by GLA gene variants leading to alpha-galactosidase A deficiency. FD is a rare cause of stroke, and it is still controversial whether in stroke patients FD should be searched from the beginning or at the end of the diagnostic workup (in cryptogenic strokes). Methods: Fabry-Stroke Italian Registry is a prospective, multicentric screening involving 33 stroke units. FD was sought by measuring α-galactosidase A activity (males) and by genetic tests (males with reduced enzyme activity and females) in patients aged 18–60 years hospitalized for TIA, ischemic stroke, or intracerebral hemorrhage. We diagnosed FD in patients with 1) already known pathogenic GLA variants; 2) novel GLA variants if additional clinical, laboratory, or family-derived criteria were present. Results: Out of 1906 patients, we found a GLA variant in 15 (0.79%; 95%CI 0.44–1.29) with a certain FD diagnosis in 3 (0.16%; 95%CI 0.03–0.46) patients, none of whom had hemorrhage. We identified 1 novel pathogenic GLA variant. Ischemic stroke etiologies in carriers of GLA variants were: cardioaortic embolism (33%), small artery occlusion (27%), other causes (20%), and undetermined (20%). Mild severity, recurrence, previous TIA, acroparesthesias, hearing loss, and small artery occlusion were predictors of GLA variant. Conclusion: In this large multicenter cohort the frequency of FD and GLA variants was consistent with previous reports. Limiting the screening for GLA variants to patients with cryptogenic stroke may miss up to 80% of diagnoses. Some easily recognizable clinical features could help select patients for FD screening
Centrality and transverse momentum dependence of elliptic flow of multi-strange hadrons and meson in Au+Au collisions at = 200 GeV
We present high precision measurements of elliptic flow near midrapidity
() for multi-strange hadrons and meson as a function of
centrality and transverse momentum in Au+Au collisions at center of mass energy
200 GeV. We observe that the transverse momentum dependence of
and is similar to that of and , respectively,
which may indicate that the heavier strange quark flows as strongly as the
lighter up and down quarks. This observation constitutes a clear piece of
evidence for the development of partonic collectivity in heavy-ion collisions
at the top RHIC energy. Number of constituent quark scaling is found to hold
within statistical uncertainty for both 0-30 and 30-80 collision
centrality. There is an indication of the breakdown of previously observed mass
ordering between and proton at low transverse momentum in the
0-30 centrality range, possibly indicating late hadronic interactions
affecting the proton .Comment: 7 pages and 4 figures, Accepted for publication in Physical Review
Letter
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