On Fabry P\'erot Etalon based Instruments. I. The Isotropic Case

Here we assess the spectral and imaging properties of Fabry P\'erot etalons when located in solar magnetographs. We discuss the chosen configuration (collimated or telecentric) for both ideal and real cases. For the real cases, we focus on the effects caused by the polychromatic illumination of the filter by the irregularities in the optical thickness of the etalon and by deviations from the ideal illumination in both setups. We first review the general properties of Fabry P\'erots and we then address the different sources of degradation of the spectral transmission profile. We review and extend the general treatment of defects followed by different authors. We discuss the differences between the point spread functions (PSFs) of the collimated and telecentric configurations for both monochromatic and (real) quasi-monochromatic illumination of the etalon. The PSF corresponding to collimated mounts is shown to have a better performance, although it varies from point to point due to an apodization of the image inherent to this configuration. This is in contrast to the (perfect) telecentric case, where the PSF remains constant but produces artificial velocities and magnetic field signals because of its strong spectral dependence. We find that the unavoidable presence of imperfections in the telecentrism produces a decrease of flux of photons and a shift, a broadening and a loss of symmetrization of both the spectral and PSF profiles over the field of view, thus compromising their advantages over the collimated configuration. We evaluate these effects for different apertures of the incident beam.Comment: 20 pages 22 figures 2 Appendice

Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: Implication for neuroprotective therapies

Neuroprotective therapies based on brain-derived neurotrophic factor (BDNF) administration have been proposed for Huntington's disease (HD) treatment. However, our group has recently reported reduced levels of TrkB in HD mouse models and HD human brain suggesting that besides a decrease on BDNF levels a reduction of TrkB expression could also contribute to diminished neurotrophic support in HD. BDNF can also bind to p75 neurotrophin receptor (p75(NTR)) modulating TrkB signaling. Therefore, in this study we have analyzed the levels of p75(NTR) in several HD models, as well as in HD human brain. Our data demonstrates a p75(NTR)/TrkB imbalance in the striatum of two different HD mouse models, Hdh(Q111/111) homozygous knockin mice and R6/1 mice that was also manifested in the putamen of HD patients. The imbalance between TrkB and p75(NTR) levels in a HD cellular model did not affect BDNF-mediated TrkB activation of prosurvival pathways but induced activation of apoptotic cascades as demonstrated by increased JNK phosphorylation. Moreover, BDNF failed to protect mutant huntingtin striatal cells transfected with p75(NTR) against NMDA-mediated excitotoxicity, which was associated with decreased Akt phosphorylation. Interestingly, lack of Akt activation following BDNF and NMDA treatment correlated with increased PP1 levels. Accordingly, pharmacological inhibition of PP1 by okadaic acid (OA) prevented mutant huntingtin striatal cell death induced by NMDA and BDNF. Altogether, our findings demonstrate that the p75(NTR)/TrkB imbalance induced by mutant huntingtin in striatal cells associated with the aberrant activity of PP1 disturbs BDNF neuroprotection likely contributing to increasing striatal vulnerability in HD. On the basis of this data we hypothesize that normalization of p75(NTR) and/or TrkB expression or their signaling will improve BDNF neuroprotective therapies in HD. Cell Death and Disease (2013) 4, e595; doi:10.1038/cddis.2013.116; published online 18 April 201

Evershed clouds as precursors of moving magnetic features around sunspots

The relation between the Evershed flow and moving magnetic features (MMFs) is studied using high-cadence, simultaneous spectropolarimetric measurements of a sunspot in visible (630.2 nm) and near-infrared (1565 nm) lines. Doppler velocities, magnetograms, and total linear polarization maps are calculated from the observed Stokes profiles. We follow the temporal evolution of two Evershed clouds that move radially outward along the same penumbral filament. Eventually, the clouds cross the visible border of the spot and enter the moat region, where they become MMFs. The flux patch farther from the sunspot has the same polarity of the spot, while the MMF closer to it has opposite polarity and exhibits abnormal circular polarization profiles. Our results provide strong evidence that at least some MMFs are the continuation of the penumbral Evershed flow into the moat. This, in turn, suggests that MMFs are magnetically connected to sunspots.Comment: To appear in ApJ Letters, Vol 649, 2006 September 20 issu

The formation and disintegration of magnetic bright points observed by Sunrise/IMaX

The evolution of the physical parameters of magnetic bright points (MBPs) located in the quiet Sun (mainly in the interwork) during their lifetime is studied. First we concentrate on the detailed description of the magnetic field evolution of three MBPs. This reveals that individual features follow different, generally complex, and rather dynamic scenarios of evolution. Next we apply statistical methods on roughly 200 observed MBP evolutionary tracks. MBPs are found to be formed by the strengthening of an equipartition field patch, which initially exhibits a moderate downflow. During the evolution, strong downdrafts with an average velocity of 2.4 km/s set in. These flows, taken together with the concurrent strengthening of the field, suggest that we are witnessing the occurrence of convective collapses in these features, although only 30% of them reach kG field strengths. This fraction might turn out to be larger when the new 4 m class solar telescopes are operational as observations of MBPs with current state of the art instrumentation could still be suffering from resolution limitations. Finally, when the bright point disappears (although the magnetic field often continues to exist) the magnetic field strength has dropped to the equipartition level and is generally somewhat weaker than at the beginning of the MBP's evolution. Noteworthy is that in about 10% of the cases we observe in the vicinity of the downflows small-scale strong (exceeding 2 km/s) intergranular upflows related spatially and temporally to these downflows.Comment: 19 pages, 13 figures; final version published in "The Astrophysical Journal

Quiet Sun magnetic fields from space-borne observations: simulating Hinode's case

We examine whether or not it is possible to derive the field strength distribution of quiet Sun internetwork regions from very high spatial resolution polarimetric observations in the visible. In particular, we consider the case of the spectropolarimeter attached to the Solar Optical Telescope aboard Hinode. Radiative magneto-convection simulations are used to synthesize the four Stokes profiles of the \ion{Fe}{1} 630.2 nm lines. Once the profiles are degraded to a spatial resolution of 0\farcs32 and added noise, we infer the atmospheric parameters by means of Milne-Eddington inversions. The comparison of the derived values with the real ones indicates that the visible lines yield correct internetwork field strengths and magnetic fluxes, with uncertainties smaller than $\sim$150 G, when a stray light contamination factor is included in the inversion. Contrary to the results of ground-based observations at 1\arcsec, weak fields are retrieved wherever the field is weak in the simulation.Comment: Accepted for publication in ApJ Letter