Our ten years of work on transparet box business simulation

Traditional business games are of the so-called black-box type (BBBS=Black box business simulator); that is to say, the internal structure which generates the results of the simulation after decision-making is not known. As a result, the player normally operates by trial and error and bases his decisions on the symptoms of the problem (the observed behaviors of the system's variables) and not on the real causes of the problem (the system's structure). Since 1988 José A.D. Machuca has insisted that the business games based on System Dynamics models should be Transparent-box business simulators (TBBSs). That means that, during the game, the user has access to the structure of the underlying model and is able to relate it to the observed behaviors. The hypothesis is that such transparency would facilitate causal reflection and favor systemic learning of business problems. In 1990, the G.I.D.E.A.O. Research Group took action on this idea and centered one of its lines of research on this matter, with three main objectives: a) Creation of TBBSs, b) Introduction of TBBSs in undergraduate and graduate Management courses as well as in executive training, c) Experimentation in controlled environments in order to test the hypothesis mentioned in the above paragraph. Now, ten years after the birth of the idea, we would like to share in this paper the results obtained during that period

Canariensis Seminarii Conciliaris theologico-dogmaticae theses : [objetionibus pro viribus satisfaciet praedictus Dominicus Huesterlin del Castillo opem ei ferente ... Fr. Dominico Gordillo ... in ejusdem Seminarii Templo die 13 jan. anno Domini 1785 ...]

Subtít. tomado de la parte final del text

Export Performance in Spanish Wineries: the Role of Human Capital and Quality Management System

This version of the article has been accepted for publication, after peer review, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1504/EJIM.2018.091372[Abstract] The aim of this paper is to research the effect of human capital and Quality Management System (QMS) on the export performance of wine firms. The empirical analysis is carried out using data from a sample of Spanish wineries and performing Tobit regression models. In relation to human capital, the results show that only the specific human capital is associated with superior export performance of wineries whereas the general human capital although it has a positive coefficient, it is not statistically significant on the export performance of wine firms. The results related to Quality Management System show that those wine firms certified with the ISO 9000 standard of QMS have better export performanc

Early statin use is an independent predictor of long-term graft survival

Background. Statin use in renal transplantation has been associated with a lower risk of patient death but not with an improvement of graft functional survival. The aim of this study is to evaluate the effect of statin use in graft survival, death-censored graft survival and patient survival using the data recorded on the Spanish Late Allograft Dysfunction Study Group

Do cross-food allergies to propofol exist?

Alergia a la comida; Sensibilización alimentaria; PropofolFood allergy; Food sensitization; PropofolAl·lèrgia alimentària; Sensibilització alimentària; PropofolBackground: Propofol is a short and rapidly acting intravenous anesthetic extensively used for the induction and maintenance of general anesthesia. It is a lipid emulsion that contains soybean oil, purified egg phosphatide, and egg lecithin. Therefore, the package leaflet indicates that its administration is contraindicated in patients allergic to soy, eggs, or peanuts. Our study aimed to determine whether patients with proven food allergies are allergic to propofol. Methods: Patients of all ages allergic to soy, eggs, or peanuts who agreed to undergo skin testing for propofol allergies were included. The subjects first underwent a skin test to confirm food allergies. If candidates were negative, they were excluded. If the result was positive, a propofol skin test was performed. Results: Sixty-four patients with confirmed food allergies underwent a propofol skin test. Only one was positive in the propofol skin test (1.6%). The patient was allergic to peanuts and soybeans. These results reinforce the idea that there is no justification for avoiding propofol use in these subjects. Conclusions: Propofol can be safely administered to patients allergic to soy, eggs, or peanuts. We recommend caution in patients with a history of anaphylaxis after ingestion of the above-mentioned foods

Immunoglobulin G as a Milk Allergen

Immunoglobulin G; Anaphylaxis; CaseinInmunoglobulina G; Anafilaxis; CaseínaImmunoglobulina G; Anafilaxi; Caseïn

A new approach to ascertain the sensitivity to water stress of different plant water indicators

[SPA] Se evaluó la sensibilidad al déficit hídrico de diferentes indicadores de estado hídrico del cultivo durante la poscosecha tardía de nectarinos extra-tempranos, en una finca comercial en la que se dispusieron dos tratamientos de riego: (i) Un control (TCTL), regado al 120 % de la evapotranspiración potencial de cultivo a fin de evitar condiciones limitantes de agua en el suelo y (II) un tratamiento de déficit hídrico (TD), regado al 50 % de TC. Los indicadores estudiados fueron: máxima contracción de tronco (MCD); tasa de crecimiento diario de tronco (TCD), potencial hídrico de tallo al mediodía (ΨT); conductancia estomática foliar (Gs); y fotosíntesis neta (Pn). Los mayores valores de intensidades de señal (SI) –ratio de los valores de TD y TCTL- se alcanzaron en TCD, Gs y Pn (2.6, 3, y 2.9, respectivamente), los valores de sensibilidad (S) –calculados como el ratio IS entre coeficiente de variación de las medidas (IS·CV-1)- fueron altos en ΨT y MCD (14 y 11.4, respectivamente), sin embargo sus coeficientes de variación fueron los menores (11 y 14 %, respectivamente). Se propone un nuevo enfoque (S*) para calcular la sensibilidad de los indicadores de estado hídrico de la planta, ya que el método tradicional puede generar altos valores de sensibilidad sin que se identifiquen diferencias entre tratamientos de riego. [ENG] The sensitivity to water stress of different plant water indicators was evaluated during the late postharvest period of extra-early nectarine trees growing in a commercial orchard and submitted to two irrigation treatments: (i) a control (TC), irrigated at 120% of crop evapotranspiration to avoid any soil water limitations, and (ii) a water deficit treatment (TD), irrigated at 50% of TC. The plant indicator studied were: the maximum daily trunk shrinkage (MCD); trunk growth rate (TCD); midday stem water potential (ΨT); leaf conductance (Gs); and net photosynthesis (Pn). Although the highest signal intensity (SI) values -the ratio of deficit irrigation treatment values to control values- were reached by TGR, Gs and Pn (2.6, 3 and 2.9, respectively), the sensitivity (S) values- calculated as the ratio of SI to coefficient of variation (SI·CV−1)- were higher in ΨT and MDS (14 and 11.4, respectively), since their CV values were the lowest (11 and 14%, respectively). A new approach (S*) is proposed to calculate the sensitivity of the plant water indicators, since the standard method can result in high sensitivity values without identifying differences between irrigation treatments.Este estudio fue subvencionado por el Ministerio Español de ciencia e innovación (AGL2010-19201-C04-04), y el proyecto europeo SIRRIMED (FP7-KBBE-2009-3-245159)

[Sobre la separación de Juan Persiva, Diputado por Las Palmas, de la Diputación Provincial

Tít. y mención de responsabilidad tomado del propio texto que no tiene tít.Datos de imp. tomados del colofó

High sensitivity and negative predictive value of the DETECT algorithm for an early diagnosis of pulmonary arterial hypertension in systemic sclerosis : application in a single center

Pulmonary arterial hypertension (PAH) is one of the most relevant causes of death in systemic sclerosis. The aims of this study were to analyse the recently published DETECT algorithm comparing it with European Society of Cardiology/European Respiratory Society (ESC/ERS) 2009 guidelines: as screening of PAH; (2) identifying median pulmonary arterial pressure (mPAP) ≥21 mmHg; and (3) determining any group of pulmonary hypertension (PH). Eighty-three patients fulfilling LeRoy's systemic sclerosis diagnostic criteria with at least right heart catheterization were studied retrospectively. Clinical data, serological biomarkers, echocardiographic and hemodynamic features were collected. SPSS 20.0 was used for statistical analysis. According to right heart catheterization findings, 35 patients with PAH and 28 with no PH met the standards for DETECT algorithm analysis: 27.0% of patients presented with functional class III/IV. Applying DETECT, the sensitivity was 100%, specificity 42.9%, the positive predictive value 68.6% and the negative predictive value 100%, whereas employing the ESC/ERS guidelines these were 91.4%, 85.7%, 88.9% and 89.3%, respectively. There were no missed diagnoses of PAH using DETECT compared with three patients missed (8.5%) using ESC/ERS guidelines. The DETECT algorithm also showed greater sensitivity and negative predictive value to identify patients with mPAP ≥21 mmHg or with any type of PH. The DETECT algorithm is confirmed as an excellent screening method due to its high sensitivity and negative predictive value, minimizing missed diagnosis of PAH. DETECT would be accurate either for early diagnosis of borderline mPAP or any group of PH