New insights from SONAR indicate adding sodium glucose co-transporter 2 inhibitors to an endothelin receptor antagonist mitigates fluid retention and enhances albuminuria reduction

The diuretic effects achieved with sodium glucose co-transporter 2 inhibitors (SGLT2i) may offset fluid retaining effects of the endothelin receptor antagonist (ERA) atrasentan while effects on albuminuria and kidney protection of both drug classes may be complimentary due to distinct mechanisms of action. Here, post-hoc analysis of the SONAR trial, in patients with type 2 diabetes and chronic kidney disease, show that six-weeks treatment with combined SGLT2i/atrasentan versus atrasentan alone decreased body weight, a surrogate for fluid retention, and further decreased albuminuria. Thus, these promising findings support future clinical studies to characterize the long-term efficacy and safety of combined SGLT2i/ERA treatment

Mapping the inner regions of the polar disk galaxy NGC4650A with MUSE

[abridged] The polar disk galaxy NGC4650A was observed during the commissioning of the MUSE at the ESO VLT to obtain the first 2D map of the velocity and velocity dispersion for both stars and gas. The new MUSE data allow the analysis of the structure and kinematics towards the central regions of NGC4650A, where the two components co-exist. These regions were unexplored by the previous long-slit literature data available for this galaxy. The extended view of NGC~4650A given by the MUSE data is a galaxy made of two perpendicular disks that remain distinct and drive the kinematics right into the very centre of this object. In order to match this observed structure for NGC4650A, we constructed a multicomponent mass model made by the combined projection of two disks. By comparing the observations with the 2D kinematics derived from the model, we found that the modelled mass distribution in these two disks can, on average, account for the complex kinematics revealed by the MUSE data, also in the central regions of the galaxy where the two components coexist. This result is a strong constraint on the dynamics and formation history of this galaxy; it further supports the idea that polar disk galaxies like NGC~4650A were formed through the accretion of material that has different angular momentum.Comment: 14 pages, 10 figures; accepted for publication in Astronomy & Astrophysic

Prevalence and Properties of Dark Matter in Elliptical Galaxies

Given the recently deduced relationship between X-ray temperatures and stellar velocity dispersions (the "T-sigma relation") in an optically complete sample of elliptical galaxies (Davis & White 1996), we demonstrate that L>L_* ellipticals contain substantial amounts of dark matter in general. We present constraints on the dark matter scale length and on the dark-to-luminous mass ratio within the optical half-light radius and within the entire galaxy. For example, we find that minimum values of dark matter core radii scale as r_dm > 4(L_V/3L_*)^{3/4}h^{-1}_80 kpc and that the minimum dark matter mass fraction is >~20% within one optical effective radius r_e and is >~39-85% within 6r_e, depending on the stellar density profile and observed value of beta_spec. We also confirm the prediction of Davis & White (1996) that the dark matter is characterized by velocity dispersions that are greater than those of the luminous stars: sigma_dm^2 ~ 1.4-2 sigma_*^2. The T-sigma relation implies a nearly constant mass-to-light ratio within six half-light radii: M/L_V ~ 25h_80 M_sun/L_V_sun. This conflicts with the simplest extension of CDM theories of large scale structure formation to galactic scales; we consider a couple of modifications which can better account for the observed T-sigma relation.Comment: 27 pages AASTeX; 15 PostScript figures; to appear in Ap

SAURON: An Innovative Look at Early-Type Galaxies

A summary of the SAURON project and its current status is presented. SAURON is a panoramic integral-field spectrograph designed to study the stellar kinematics, gaseous kinematics, and stellar populations of spheroids. Here, the sample of galaxies and its properties are described. The instrument is detailed and its capabilities illustrated through observational examples. These includes results on the structure of central stellar disks, the kinematics and ionization state of gaseous disks, and the stellar populations of galaxies with decoupled cores.Comment: 10 pages, 6 figures. To appear in "The Dynamics, Structure & History of Galaxies", eds. G. S. Da Costa & E. M. Sadler (San Francisco: ASP). Version with full resolution images available at http://www.strw.leidenuniv.nl/~dynamics/Instruments/Sauron/pub_list.htm

SAURON Observations of Disks in Spheroids

The panoramic integral-field spectrograph SAURON is currently being used to map the stellar kinematics, gaseous kinematics, and stellar populations of a large number of early-type galaxies and bulges. Here, we describe SAURON observations of cold stellar disks embedded in spheroids (NGC3384, NGC4459, NGC4526), we illustrate the kinematics and ionization state of large-scale gaseous disks (NGC4278, NGC7742), and we show preliminary comparisons of SAURON data with barred galaxy N-body simulations (NGC3623).Comment: 8 pages including 5 figures. To appear in Galaxies: The Third Dimension, eds. M. Rosado, L. Binnette, & L. Arias (ASP: San Francisco

A SAURON view of galaxies

We have measured the two-dimensional kinematics and line-strength distributions of 72 representative nearby early-type galaxies, out to approximately one effective radius, with our panoramic integral-field spectrograph SAURON. The resulting maps reveal a rich variety in kinematical structures and linestrength distributions, indicating that early-type galaxies are more complex systems than often assumed. We are building detailed dynamical models for these galaxies, to derive their intrinsic shape and dynamical structure, and to determine the mass of the supermassive central black hole. Here we focus on two examples, the compact elliptical M32 and the E3 galaxy NGC4365. These objects represent two extreme cases: M32 has very regular kinematics which can be represented accurately by an axisymmetric model in which all stars rotate around the short axis, while NGC4365 is a triaxial galaxy with a prominent kinematically decoupled core, with an inner core that rotates about an axis that is nearly perpendicular to the rotation axis of the main body of the galaxy. Our dynamical models for these objects demonstrate that two-dimensional observations are essential for deriving the intrinsic orbital structure and dark matter content of galaxies.Comment: 7 pages (3 figures, full resolution Fig. 1 available at http://www.strw.leidenuniv.nl/~verolme/M32.ps). Contributed talk to the Athens Workshop on Galaxies and Chaos, Theory and Observations; Proceedings to appear in "Galaxies and Chaos", eds. G. Contopoulos and N. Vogli