Spatiotemporal Hydrological Modelling with GIS for the Upper Mahaweli Catchment, Sri Lanka

Sustainability of water resources is imperative for the continued prosperity of Sri Lanka where the economy is dependent upon agriculture. The Mahaweli river is the longest in Sri Lanka, with the upper catchment covering an area of 3124 sq .km .. The Mahaweli Development programme, a major undertaking in the upper catchment has been implemented with the aims of providing Mahaweli water to the dry zone of the country through a massive diversion scheme and also for generating hydropower. Under this programme, seven large reservoirs have been constructed across the river and large scale land use changes in the catchment have occurred during the last two decades. Critics now say that the hydrological regime has been adversely affected due to indiscriminate land use changes and, as a result, river flows have diminished during the last two decades, thus jeopardising the expectations of this massive development programme. Reforestation programmes have been recommended because of the benefits of forest in resource conservation and also the water derived from fog interception. Selection of the best sites for these forest plantations for maximum benefits, especially in terms of water yield from fog interception has the utmost importance. This created the need for a comprehensive model to represent the hydrology and to simulate the hydrological dynamics of the catchment In conceptual terms, GIS is well suited for modelling with large and complex databases associated with hydrological parameters. However, hydrological modelling efforts in GIS are constrained by the limitations in the representation of time in its spatial data ,structures. The SPANS GIS software used in this study provided the capability of linking spatially distributed numerical parameters with corresponding tabulated data through mathematical and statistical expressions while implicitly representing temporality through iterative procedures.The spatial distribution of land use was identified through the supervised classification of IRS-IA LISS II imagery. Daily rainfall data for a 30 year period and corresponding gauging locations derived from GPS were managed and retrieved through a Lotus 1-2- 3 database. The fog interception component was estimated based on elevation and the monsoon season. Hydrological processes such as interception and evapotranspiration were derived from individual sub models and finally combined within the overall hydrological model structure. The model was run with daily time steps on numerical 'values of each quad cell of the thematic coverage. The information on flow derived from the model was depicted as a series of thematic maps in addition to the time series of numerical values at subcatchment and catchment outlets. The results confirmed that the model is capable of simulating catchment response of the UMCA successfully. The time dimension was accommodated through a senes of non-interactive REXX programmes in developing the customised version of the model. It is concluded that the software architecture of SPANS GIS is capable of accommodating spatiotemporal modelling implicitly in its spatial data structures although changes in the model structure may necessitate considerable reprogramming. Sensitivity of the model for different spatial interpolation techniques was evaluated. Further, sensitivity of the model for the defined hydrological parameters, spatial 'resolution and land use was also assessed. The model is sensitive to land use changes in the catchment and it shows 15-35% annual increase of runoff when forests are converted to grassland. Further studies are required to develop a more detailed set of hydrological parameters for the model

Ethnolinguistic concordance and the receipt of postpartum IUD counseling services in Sri Lanka.

CONTEXT: Ethnic and linguistic concordance are important dimensions of the patient-physician relationship, and are linked to health care disparities. However, evidence on the associations between health behavior and outcomes and patient-provider concordance is limited, especially in low- and middle-income settings. METHODS: To examine how concordance between women and their primary health midwife is associated with women's receipt of postpartum IUD counseling, observational data from a cluster-randomized trial assessing an intervention to increase postpartum IUD counseling were used. Data on 4,497 women who delivered at six hospitals in Sri Lanka between September 2015 and March 2017 were merged with data on 245 primary health midwives, and indicators of linguistic concordance, ethnic concordance and their interaction were generated. Multivariate logistic regression analyses were used to assess the associations between concordance and women's receipt of counseling. RESULTS: Women from non-Sinhalese groups in Sri Lanka face disparities in the receipt of postpartum IUD counseling. Compared with the ethnolinguistic majority (Sinhalese women who speak only Sinhala), non-Sinhalese women have lower odds of having received postpartum IUD counseling, whether they speak both Sinhala and Tamil (odds ratio, 0.6) or only Tamil (0.5). Ethnic discordance- rather than linguistic discordance-is the primary driver of this disparity. CONCLUSIONS: The findings highlight the need for interventions that aim to bridge the sociocultural gaps between providers and patients. Matching women and their providers on ethnolinguistic background may help to reduce disparities in care.Accepted manuscrip

The effect of a postpartum IUD intervention on counseling and choice: Evidence from a cluster-randomized stepped-wedge trial in Sri Lanka

BACKGROUND: The International Federation of Gynaecology and Obstetrics (FIGO), in collaboration with the Sri Lankan College of Obstetrics and Gynaecologists (SLCOG), launched an initiative in 2014 to institutionalize immediate postpartum IUD (PPIUD) services as a routine part of antenatal counseling and delivery room services in Sri Lanka. In this study, we evaluate the effect of the FIGO-SLCOG PPIUD intervention in six hospitals by means of a cluster-randomized stepped-wedge trial. METHODS/DESIGN: Six hospitals were randomized into two groups of three using matched pairs. Following a 3-month baseline period, the intervention was administered to the first group, while the second group received the intervention after 9 months of baseline data collection. We collected data from 39,084 women who delivered in these hospitals between September 2015 and January 2017. We conduct an intent-to-treat (ITT) analysis to determine the impact of the intervention on PPIUD counseling and choice of PPIUD, as measured by consent to receive a PPIUD, as well as PPIUD uptake (insertion following delivery). We also investigate how factors related to counseling, such as counseling timing and quality, are linked to choice of PPIUD. RESULTS: We find that the intervention increased rates of counseling, from an average counseling rate of 12% in all hospitals prior to the intervention to an average rate of 51% in all hospitals after the rollout of the intervention (0.307; 95% CI 0.148-0.465). In contrast, we find the impact of the intervention on choice of PPIUD to be less robust and mixed, with 4.1% of women choosing PPIUD prior to the intervention compared to 9.8% of women choosing PPIUD after the rollout of the intervention (0.027; 95% CI 0.000-0.054). CONCLUSIONS: This study demonstrates that incorporating PPIUD services into postpartum care is feasible and potentially effective. Taking the evidence on both counseling and choice of PPIUD together, we find that the intervention had a generally positive impact on receipt of PPIUD counseling and, to a lesser degree, on choice of the PPIUD. Nevertheless, it is clear that the intervention's effectiveness can be improved to be able to meet the demand for postpartum family planning of women. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02718222 . Registered on 11 March 2016 (retrospectively registered).Published version and Accepted manuscript versions

Institutions, impact synergies and food security: a methodology with results from the Kala Oya Basin, Sri Lanka

Institutional development / Development plans / Development policy / Impact assessment / River basins / Food security / Models

A study of methodologies and critical parameters associated With co2 storage estimation in deep saline aquifers

Deep saline aquifers have greater potential for carbon dioxide (CO2) storage (around 12,000 Gt global capacity) than alternative storage media and could be adopted anywhere in the world. It is important to understand methodologies for the estimation of CO2 storage capacities in relation to different trapping mechanisms and the extent to which critical parameters such as aquifer thickness, porosity, salinity and permeability are taken into account. Storage security will improve over time, especially as a result of mineral trapping. This paper reviews methods of estimating CO2 storage potential from earlier studies and numerically estimates the storage potential in saline aquifers considering critical parameters such as saline aquifer and porosity

Improving decision support system in identifying vulnerability rating and prioritizing the best interventions for sustainable watersheds in Pakistan, Nepal, and Sri Lanka

Quantification of watershed vulnerability rating and prioritization of the best watershed management intervention is always a challenge for multidisciplinary experts in developing consensus. Consequently, the lack of a decision support system (DSS) negatively affects the adoption of promising interventions leading to reduced watershed communities’ resilience to climate change. Therefore, a DSS has been developed to integrate local multi-disciplinary knowledge in identifying the watershed vulnerability ratings and prioritizing the best site-specific watershed management interventions. The DSS developed was applied to selected watersheds using 25 local experts each in Pakistan, Nepal, and Sri Lanka. The results showed the DSS is conveniently applicable and effective in developing consensus among multidisciplinary experts. The DSS recommended that the best interventions for the selected watersheds should primarily reduce the existing accelerated land and water degradation through engineering and biological actions, namely the control the rainwater run-off losses through appropriate harvesting systems and their subsequent efficient utilization for improving food security, climate change resilience and livelihood of vulnerable watershed communities. The DSS developed can be helpful in developing local adaptation plans and strengthening the policy support for promoting sustainable watersheds in Pakistan, Nepal, and Sri Lanka. However, the system needs further refinement through the incorporation of the design, specifications and costing of the interventions and making the data acquisition and analysis automatic using an online electronic system for quicker results and appropriate resource allocation for stimulated adoption.Quantification of watershed vulnerability rating and prioritization of the best watershed management intervention is always a challenge for multidisciplinary experts in developing consensus. Consequently, the lack of a decision support system (DSS) negatively affects the adoption of promising interventions leading to reduced watershed communities’ resilience to climate change. Therefore, a DSS has been developed to integrate local multi-disciplinary knowledge in identifying the watershed vulnerability ratings and prioritizing the best site-specific watershed management interventions. The DSS developed was applied to selected watersheds using 25 local experts in Pakistan, Nepal, and Sri Lanka. Results showed that DSS is conveniently applicable and effective in developing consensus among multidisciplinary experts. The DSS recommended that the best interventions for the selected watersheds should primarily reduce the existing accelerated land and water degradation through engineering and biological actions. These actions may include controlling the rainwater run-off losses through appropriate harvesting systems and their subsequent efficient utilization for improving food security, climate change resilience and livelihood of vulnerable watershed communities. The DSS developed can be helpful in developing local adaptation plans and strengthening the policy support for promoting sustainable watersheds in Pakistan, Nepal, and Sri Lanka. However, the system needs further refinement through the incorporation of the design, specifications and costing of the interventions and making the data acquisition and analysis automatic using an online electronic system for quicker results and appropriate resource allocation for stimulated adoption

Mitogen activated kinases (MAPK) and protein phosphatases are involved in Aspergillus fumigatus adhesion and biofilm formation

We would like to thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) for providing financial support. LW and CM would like to acknowledge support from the University of Aberdeen and the MRC Centre for Medical Mycology (MR/N006364/1). All authors declare no financial conflict of interest.Peer reviewedPostprin

Muteness Failure Detectors, Specification and Implementation

This paper extends the failures detector approach from crash-stop failures to muteness failures. Muteness failures are malicious failures in which a process stops sending algorithm messages, but might continue to send other messages, e.g. 'I-am-alive' messages. The paper presents both the specification of a muteness failure detector, denoted by MA, and an implementation of MA in a partial synchrony model (there are bounds on message latency and clock skew, but these bounds are unknown and hold only after some point that is itself unknown). We show that, modulo a simple modification, a consensus algorithm that has been designed in a crash-stop model with S, can be reused in the presence of muteness failures simply by replacing MA with S

A novel therapeutic effect of mannitol-rich extract from the brown seaweed Sargassum ilicifolium using in vitro and in vivo models

Background: Wound healing is an active, complex, integrated series of cellular, physiological, and biochemical changes initiated by the stimulus of injury in a tissue. The present study was performed to investigate the potential wound healing abilities of Sargassum ilicifolium crude extracts (CE) that were characterized by 1H NMR and FTIR Spectrometric measurements. Materials and methods: Seaweed samples were collected from southern coastal sites of Sri Lanka. To determine the cytotoxicity and proliferation of S. ilicifolium CE were used for the MTT and alamarBlue assays respectively. The scratch and exclusion wound models were used to HaCaT and HDF cells to assess the cell proliferation and migration. RAW 264.7 cells (macrophages) were used to evaluate Nitric Oxide (NO) production and phagocytosis activities. Moreover, Fifteen, 8-week-old, female, New Zealand rabbits were selected and divided into five groups: excision skin wounds (10.40 ± 0.60 mm) were induced in groups I, II, and III. Rabbits in groups I and IV were given S. ilicifolium CE (orally, 100 mg/kg day, two weeks), whereas groups II and V were given equal amounts of distilled water. Wound healing properties were measured and wound tissue samples were collated, formalin-fixed, wax-embedded, stained (Hematoxylin and Eosin; Van Gieson) and examined for the healing process. Results: Anti-inflammatory and wound healing activities were observed in RAW 264.7, HDF and HaCaT cells treated with S. ilicifolium aqueous extracts when compared to the control groups. S. ilicifolium extracts concentration 8 - 4 μg/μL, (P<0.05) had remarkable the highest proliferative and migratory effects on RAW 264.7, HDF and HaCaT cells when compared with the control. RAW 264.7 cell proliferation and/or migration were higher in S. ilicifolium extracts (4 μg/μL, 232.8 ± 10.07%) compared with the control (100 %). Scratch wound healing were remarkably enhanced in 24 h, 48 h (P<0.05) when treated with S. ilicifolium on HaCaT cells. Rabbits treated with the CE of S. ilicifolium showed a significantly increased wound healing activities (P<0.05) within three days with a close wound area of 57.21 ± 0.77 % compared with control group (26.63 ± 1.09 %). Histopathology, aspartate aminotransferase and alanine aminotransferase levels evidenced no toxic effects on seaweed treated groups. Histopathological results also revealed that the healing process was significantly faster in the rabbit groups which were as treated with CE of S. ilicifolium orally with the evidence of enhanced early granulation tissue (connective tissue and angiogenesis) and significant epithelization compared to the control. Conclusions: Cell proliferation and migration are significantly faster when treated with S. ilicifolium aqueous extracts. Moreover, there are no toxic effect of S. ilicifolium aqueous extracts on RAW 264.7, HDF and HaCaT cell lines. In this study, it is revealed that S. ilicifolium has potential remedial agent; D-Mannitol for skin wound healing properties that by promote keratinocyte and fibroblast proliferation and migration. These findings show that S. ilicifolium have promising wound healing properties

Prevalence of inflammatory bowel disease in two districts of Sri Lanka: a hospital based survey

<p>Abstract</p> <p>Background</p> <p>Inflammatory bowel disease (IBD) is being increasingly diagnosed in Asia. However there are few epidemiological data from the region.</p> <p>Methods</p> <p>To determine prevalence and clinical characteristics of IBD, a hospital-based survey was performed in the Colombo and Gampaha districts (combined population 4.5 million) in Sri Lanka. Patients with established ulcerative colitis (UC) and Crohn's disease (CD), who were permanent residents of these adjoining districts, were recruited from hospital registries and out-patient clinics. Clinical information was obtained from medical records and patient interviews.</p> <p>Results</p> <p>There were 295 cases of IBD (UC = 240, CD = 55), of which 34 (UC = 30, CD = 4) were newly diagnosed during the study year. The prevalence rate for UC was 5.3/100,000 (95% CI 5.0-5.6/100,000), and CD was 1.2/100,000 (95% CI 1.0-1.4/100,000). The incidence rates were 0.69/100,000 (95% CI 0.44-0.94/100,000) for UC and 0.09/100,000 (95% CI 0.002-0.18/100,000) for CD. Female:male ratios were 1.5 for UC and 1.0 for CD. Mean age at diagnosis was (males and females) 36.6 and 38.1y for UC and 33.4 and 36.2y for CD. Among UC patients, 51.1% had proctitis and at presentation 58.4% had mild disease. 80% of CD patients had only large bowel involvement. Few patients had undergone surgery.</p> <p>Conclusions</p> <p>The prevalence of IBD in this population was low compared to Western populations, but similar to some in Asia. There was a female preponderance for UC. UC was mainly mild, distal or left-sided, while CD mainly involved the large bowel.</p