31 research outputs found
Healthy lifestyles of the university population
El estilo de vida se define como el conjunto de pautas y hábitos comportamentales cotidianos de una persona, que mantenidos en el tiempo pueden constituirse en dimensiones de riesgo o de seguridad dependiendo de su naturaleza. Los objetivos del presente trabajo han sido conocer los estilos de vida de los jóvenes universitarios en las siguientes dimensiones: alimentación, ejercicio físico, consumo de tabaco, alcohol y otras drogas, relaciones sexuales y seguridad vial. Para ello se ha realizado una revisión bibliográfica en las bases de datos electrónicas: PUBMED, SCIELO y CUIDEN entre los años 2002-2014; utilizando como palabras claves: estilos de vida, conductas saludables, dieta, ejercicio, drogas, estudiantes universitarios. De los artículos encontrados, destacar como dato más relevante, que los jóvenes universitarios poseen una alta presencia de creencias favorables sobre hábitos de vida saludables y a pesar de ello, no lo llevan a la práctica. Tras realizar una exhaustiva revisión podemos concluir que según los distintos autores, los jóvenes universitarios en general, no tienen buenos hábitos alimentarios, consumiendo dietas desequilibradas con alto contenido calórico. Además la práctica del ejercicio físico es nula, aun sabiendo que una buena alimentación y la realización de ejercicio tienen efectos beneficiosos sobre la salud. A esto hay que añadirle el consumo elevado de alcohol, tabaco y marihuana entre los jóvenes universitarios.The lifestyle is defined as the set of behavioral patterns
and daily habits of a person, which maintained over time
may become dimensions of risk or safety depending on
their nature.
The aim of this study was to know the lifestyles of university
students in the following dimensions: diet, exercise,
consumption of tobacco, alcohol and other drugs, sex
and road safety.
We made a literature review in electronic databases:
PubMed, SCIELO and CUIDEN, between 2002-2014;
using as keywords habits, lifestyle, health behaviors,
young adult and university students.
From articles found, stand out as most relevant data
that university students have a high presence of favorable
beliefs about healthy lifestyles and nevertheless not
put into practice.
We could conclude that according to different authors,
university students in general have not a good eating
habits, eating unbalanced diets high in calories. Besides
the physical exercise is null, knowing that a good diet and
doing exercise have beneficial effects on health. To this
must be added the high consumption of alcohol, tobacco
and marijuana among university students
Therapeutic doses of nonsteroidal anti-inflammatory drugs inhibit osteosarcoma MG-63 osteoblast-like celss maturation, viability, and biomineralization potential
Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used to reduce pain and inflammation. However, their effect on bone metabolisms is not well known, and results in the literature are contradictory. The present study focusses on the effect of dexketoprofen, ketorolac, metamizole, and acetylsalicylic acid, at therapeutic doses, on different biochemical and phenotypic pathways in human osteoblast-like cells. Osteoblasts (MG-63 cell line) were incubated in culture medium with 1–10 M of dexketoprofen, ketorolac, metamizole, and acetylsalicylic acid. Flow cytometry was used to study antigenic profile and phagocytic activity. The osteoblastic differentiation was evaluated by mineralization and synthesis of collagen fibers by microscopy and alkaline phosphatase activity (ALP) by spectrophotometric assay. Short-term treatment with therapeutic doses of NSAIDs modulated differentiation, antigenic profile, and phagocyte activity of osteoblast-like cells. The treatment reduced ALP synthesis and matrix mineralization. However, nonsignificant differences were observed on collagen syntheses after treatments. The percentage of CD54 expression was increased with all treatments. CD80, CD86, and HLA-DR showed a decreased expression, which depended on NSAID and the dose applied. The treatments also decreased phagocyte activity in this cellular population. The results of this paper provide evidences that NSAIDs inhibit the osteoblast differentiation process thus reducing their ability to produce new bone mineralized extracellular matrix.This study was supported by the BIO277 research group (Junta de Andalucía), by the Department of Nursing, Faculty of Health Sciences, University of Granada and by the research group Brighton Studies in Tissue-mimicry and Aided Regeneration (BrightSTAR), School of Pharmacy & Biomolecular Sciences, University of Brighton
Analysis of the Lifestyle of Spanish Undergraduate Nursing Students and Comparison with Students of Other Degrees
Background: Nursing students are exposed to concepts of healthy lifestyles while they are
attending university. Objective: The aim of this study was to analyze whether nursing students have
a healthier lifestyle than non-nursing students and to determine whether their behaviour is consistent
with their beliefs. Methods: A cross-sectional study, with 293 university students was performed
by using a validated questionnaire to measure beliefs and behaviour regarding health. Results:
The lifestyle pattern of the nursing students evaluated was characterised by a high percentage of
nurses with low levels of physical activity, poor balanced diet and smoking habits. The comparative
analysis showed no significant differences between nursing students and students from other degrees.
Conclusions: Students have a positive attitude and knowledge about healthy lifestyle, but do not
transfer it to their own lives. Nurses’ lifestyle can unintentionally affect the behaviour of other people
through their own behaviour and beliefs because they serve as a model for a healthy lifestyle. These
findings support that nurse educators have an active role as promoter of health by using lessons to
modify the behaviour of their students
Role of Vitamin D in the Metabolic Syndrome
This study was supported by research group BIO277 (Junta de Andalucía) and
the Department of Nursing (University of Granada).The prevalence of hypovitaminosis D has risen in developed countries over the past few years in association with lifestyle changes and an increase in unhealthy habits. Vitamin D deficiency has been implicated in various diseases, including metabolic syndrome (MetS), which is clinically defined by a set of metabolic and vascular disorders. The objective of this study was to review scientific evidence on the relationship between MetS and vitamin D deficiency to support the development of prevention strategies and health education programs. An inverse relationship has been reported between plasma vitamin D concentrations and the features that define MetS, i.e., elevated serum concentrations of glucose, total cholesterol, low-density lipoproteins, triglycerides, glycosylated hemoglobin, and a high body mass index. Numerous studies have described the benefits of vitamin D supplementation to improve outcomes in individuals with MetS. Interventions to maintain optimal vitamin D concentrations are proposed as a preventive strategy against MetS.Junta de AndaluciaDepartment of Nursing (University of Granada
Biological properties and therapeutic applications of garlic and its components
This study was supported by research group BIO277 (Junta de Andalucia) and Department of Nursing (University of Granada).Garlic is one of the most widely employed condiments in cooking. It has also been used since ancient
times in traditional plant-based medicine, largely based on its organosulfur compounds. The objective of
this study was to provide updated information on the biological and therapeutic garlic properties. Garlic
has been found to possess important biological properties with high therapeutic potential, which is
influenced by the mode of its utilization, preparation, and extraction. It has been attributed with antioxidant,
anti-inflammatory, and immunomodulatory capacities. Garlic, in particular its organosulfur compounds,
can maintain immune system homeostasis through positive effects on immune cells, especially
by regulating cytokine proliferation and expression. This may underlie their usefulness in the treatment of
infectious and tumor processes. These compounds can also offer vascular benefits by regulating lipid
metabolism or by exerting antihypertensive and antiaggregant effects. However, further clinical trials are
warranted to confirm the therapeutic potential of garlic and its derivatives.Department of Nursing (University of Granada)Junta de Andaluci
Potential Effects of Phenolic Compounds That Can Be Found in Olive Oil on Wound Healing
This study was supported by research group BIO277 (Junta de Andalucia) and the Department of Nursing of the University of Granada. We would also like to thank Concepcion Ruiz for the considerations and retouches made to this paper.The treatment of tissue damage produced by physical, chemical, or mechanical agents
involves considerable direct and indirect costs to health care systems. Wound healing involves a series
of molecular and cellular events aimed at repairing the defect in tissue integrity. These events can be
favored by various natural agents, including the polyphenols in extra virgin olive oil (EVOO). The
objective of this study was to review data on the potential effects of different phenolic compounds
that can also be found in EVOO on wound healing and closure. Results of in vitro and animal
studies demonstrate that polyphenols from different plant species, also present in EVOO, participate
in different aspects of wound healing, accelerating this process through their anti-inflammatory,
antioxidant, and antimicrobial properties and their stimulation of angiogenic activities required for
granulation tissue formation and wound re-epithelialization. These results indicate the potential
usefulness of EVOO phenolic compounds for wound treatment, either alone or in combination with
other therapies. Human studies are warranted to verify this proposition.Junta de Andalucia BIO277Department of Nursing of the University of Granad
Effect of olive oil phenolic compounds on osteoblast differentiation
"This is the peer reviewed version of the following article: Melguizo-Rodríguez L., Manzano-Moreno F.J., De Luna-Bertos E., Rivas A., Ramos-Torrecillas J., Ruiz C., García-Martínez O. Effect of olive oil phenolic compounds on osteoblast differentiation. European Journal of Clinical Investigation, 2018; 48(4): 1-6, which has been published in final form at 10.1111/eci.12904. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited."Background: Osteoporosis is a skeletal disorder characterized by compromised bone strength that predisposes individuals to an increased risk of fracture. Previous in vivo and in vitro studies have reported that phenolic compounds present in extra virgin olive oil have a beneficial effect on osteoblasts in terms of increase cell proliferation. The aim of this study was to determine whether phenolic compounds present in olive oil could modify the expression of cell differentiation markers on osteoblasts.
Study Design: An in vitro experimental design was peformed using MG-63 osteoblasts cell line.
Methods: MG63 cells were exposed to different doses of luteolin, apigenin, or p-coumaric, caffeic, or ferulic acid. Alkaline phosphatase (ALP) was evaluated by spectrophotometry and antigen expression (CD54, CD80, CD86, and HLA-DR) by flow cytometry.
Results: At 24 h, treated groups showed an increased ALP and modulated antigen profile, with respect to the non-treated group.
Conclusion: These results demonstrate that the phenolic compounds studied induce cell maturation in vitro, increasing ALP synthesis and reducing the expression of antigens involved in immune functions of the osteoblast which would improve bone density.GRUPO BIO-27
Phenolic compounds in extra virgin olive oil stimulate human osteoblastic cell proliferation
In this study, we aimed to clarify the effects of phenolic compounds and extracts from different extra virgin olive oil (EVOO) varieties obtained from fruits of different ripening stages on osteoblast cells (MG-63) proliferation. Cell proliferation was increased by hydroxytyrosol, luteolin, apigenin, p-coumaric, caffeic, and ferulic acids by approximately 11–16%, as compared with controls that were treated with one vehicle alone, while (+)-pinoresinol, oleuropein, sinapic, vanillic acid and derivative (vanillin) did not affect cell proliferation. All phenolic extracts stimulated MG-63 cell growth, and they induced higher cell proliferation rates than individual compounds. The most effective EVOO phenolic extracts were those obtained from the Picual variety, as they significantly increased cell proliferation by 18–22%. Conversely, Arbequina phenolic extracts increased cell proliferation by 9–13%. A decline in osteoblast proliferation was observed in oils obtained from olive fruits collected at the end of the harvest period, as their total phenolic content decreases at this late stage. Further research on the signaling pathways of olive oil phenolic compounds involved in the processes and their metabolism should be carried out to develop new interventions and adjuvant therapies using EVOO for bone health (i.e.osteoporosis) in adulthood and the elderly
Human Fibroblast Gene Expression Modulation Using 940 NM Diode Laser
Low-Level Laser Therapy is used as regenerative therapy in different clinical fields. This is due to its
photobiomodulation effect via cell signaling on different cell populations, Including fibroblasts, cells
involved in tissue regeneration and healing. The aim was to analyze the effect of 940 nm diode laser on
the gene expression of different markers involved in fibroblast growth, differentiation, and migration.
Real-time polymerase chain reaction (q-RT-PCR) was used to quantify the expression of fibroblast
growth factor (FGF), connective tissue growth factor (CTGF), vascular-endothelial growth factor
(VEGF), transforming growth factor β1 (TGF-β1), TGFβ-receptors (TGFβR1, TGFβR2, and TGFβR3),
discoidin-domain receptor-2 (DDR2), matrix metalloproteinase-2 (MMP2), α-actin, fibronectin, decorin,
and elastin on human fibroblast, treated with single dose (T1) or two doses (T2) of diode laser at 0.5
Watts and 4 J/cm2. A significant increase in the expression of FGF, TGF-β1, TGFβR1, TGFβR2, α-actin,
fibronectin, decorin, DDR2 and MMP2 was observed after both treatments. A decrease was observed
in expression of elastin (T1 and T2), and CTGF (T2). These changes underlie the biostimulatory effect
of laser on fibroblasts, which translates into an increase in short-term proliferation and in long-term
differentiation to myofibroblasts. These data support the therapeutic potential of diode laser for wound
repair
Effects of bisphenol F, bisphenol S, and bisphenol AF on cultured human osteoblasts
Bisphenol A (BPA) analogs, like BPA, could have adverse effects on human health including bone health. The aim was to
determine the effect of BPF, BPS and BPAF on the growth and differentiation of cultured human osteoblasts. Osteoblasts
primary culture from bone chips harvested during routine dental work and treated with BPF, BPS, or BPAF for 24 h at doses
of 10 –5 , 10 –6 , and 10 –7 M. Next, cell proliferation was studied, apoptosis induction, and alkaline phosphatase (ALP) activity.
In addition, mineralization was evaluated at 7, 14, and 21 days of cell culture in an osteogenic medium supplemented with BP
analog at the studied doses. BPS treatment inhibited proliferation in a dose-dependent manner at all three doses by inducing
apoptosis; BPF exerted a significant inhibitory effect on cell proliferation at the highest dose alone by an increase of apopto-
sis; while BPAF had no effect on proliferation or cell viability. Cell differentiation was adversely affected by treatment with
BPA analogs in a dose-dependent, observing a reduction in calcium nodule formation at 21 days. According to the results
obtained, these BPA analogs could potentially pose a threat to bone health, depending on their concentration in the organism.Funding for open access publishing: Universidad de Granada/
CBU