232 research outputs found
Molecular dynamics simulations of ion clustering and conductivity in NaI/ether solutions. I. Effect of ion charge
Molecular dynamics simulations of ion clustering and conductivity in NaI/ether solutions. II. Effect of ion concentration
The causes of the red sequence, the blue cloud, the green valley, and the green mountain
The galaxies found in optical surveys fall in two distinct regions of a diagram of optical colour versus absolute magnitude: the red sequence and the blue cloud, with the green valley in between. We show that the galaxies found in a submillimetre survey have almost the opposite distribution in this diagram, forming a \u27green mountain\u27. We show that these distinctive distributions follow naturally from a single, continuous, curved Galaxy Sequence in a diagram of specific star formation rate versus stellar mass, without there being the need for a separate star-forming galaxy main sequence and region of passive galaxies. The cause of the red sequence and the blue cloud is the geometric mapping between stellar mass/specific star formation rate and absolute magnitude/colour, which distorts a continuous Galaxy Sequence in the diagram of intrinsic properties into a bimodal distribution in the diagram of observed properties. The cause of the green mountain isMalmquist bias in the submillimetre waveband, with submillimetre surveys tending to select galaxies on the curve of the Galaxy Sequence, which have the highest ratios of submillimetre-to-optical luminosity. This effect, working in reverse, causes galaxies on the curve of the Galaxy Sequence to be underrepresented in optical samples, deepening the green valley. The green valley is therefore not evidence (1) for there being two distinct populations of galaxies, (2) for galaxies in this region evolving more quickly than galaxies in the blue cloud and the red sequence, and (3) for rapid-quenching processes in the galaxy population
Graphite and Hexagonal Boron-Nitride Possess the Same Interlayer Distance. Why?
Graphite and hexagonal boron nitride (h-BN) are two prominent members of the
family of layered materials possessing a hexagonal lattice. While graphite has
non-polar homo-nuclear C-C intra-layer bonds, h-BN presents highly polar B-N
bonds resulting in different optimal stacking modes of the two materials in
bulk form. Furthermore, the static polarizabilities of the constituent atoms
considerably differ from each other suggesting large differences in the
dispersive component of the interlayer bonding. Despite these major differences
both materials present practically identical interlayer distances. To
understand this finding, a comparative study of the nature of the interlayer
bonding in both materials is presented. A full lattice sum of the interactions
between the partially charged atomic centers in h-BN results in vanishingly
small monopolar electrostatic contributions to the interlayer binding energy.
Higher order electrostatic multipoles, exchange, and short-range correlation
contributions are found to be very similar in both materials and to almost
completely cancel out by the Pauli repulsions at physically relevant interlayer
distances resulting in a marginal effective contribution to the interlayer
binding. Further analysis of the dispersive energy term reveals that despite
the large differences in the individual atomic polarizabilities the
hetero-atomic B-N C6 coefficient is very similar to the homo-atomic C-C
coefficient in the hexagonal bulk form resulting in very similar dispersive
contribution to the interlayer binding. The overall binding energy curves of
both materials are thus very similar predicting practically the same interlayer
distance and very similar binding energies.Comment: 18 pages, 5 figures, 2 table
Unified description of potential profiles and electrical transport in unipolar and ambipolar organic field-effect transistors
Pathogenic variants in the paired-related homeobox 1 gene (PRRX1) cause craniosynostosis with incomplete penetrance
Purpose
Studies previously implicated PRRX1 in craniofacial development, including demonstration of murine Prrx1 expression in the pre-osteogenic cells of the cranial sutures. We investigated the role of heterozygous missense and loss-of-function variants in PRRX1 associated with craniosynostosis.
Methods
Trio-based genome, exome or targeted sequencing were used to screen PRRX1 in patients with craniosynostosis; immunofluorescence analyses were used to assess nuclear localization of wild-type and mutant proteins.
Results
Genome sequencing identified 2 of 9 sporadically affected individuals with syndromic/multisuture craniosynostosis who were heterozygous for rare/undescribed variants in PRRX1. Exome or targeted sequencing of PRRX1 revealed a further 9/1449 patients with craniosynostosis harboring deletions or rare heterozygous variants within the homeodomain. By collaboration, seven additional individuals (four families) were identified with putatively pathogenic PRRX1 variants. Immunofluorescence analyses showed that missense variants within the PRRX1 homeodomain cause abnormal nuclear localization. Of patients with variants considered likely pathogenic, bicoronal or other multi-suture synostosis was present in 11/17 (65% of the cases). Pathogenic variants were inherited from unaffected relatives in many instances, yielding a 12.5% penetrance estimate for craniosynostosis.
Conclusion
This work supports a key role for PRRX1 in cranial suture development and shows that haploinsufficiency of PRRX1 is a relatively frequent cause of craniosynostosis
PsyToolkit: A Novel Web-Based Method for Running Online Questionnaires and Reaction-Time Experiments
This article reviews PsyToolkit, a free web-based service designed for setting up, running, and analyzing online questionnaires and reaction-time (RT) experiments. It comes with extensive documentation, videos, lessons, and libraries of free-to-use psychological scales and RT experiments. It provides an elaborate interactive environment to use (or modify) the existing questionnaires and experiments from the PsyToolkit library or to design new studies. Once users have set up their study, they can recruit participants for online participation, and data can be downloaded in spreadsheet format after collection. This article provides examples of how questionnaires and RT experiments can be set up using the website. The PsyToolkit links to online questionnaires and experiments, and these links can easily be embedded in social media networks for participant recruitment, including Amazon's Mechanical Turk. PsyToolkit’s exhaustive documentation enables students to work independently. This article finishes with pedagogical considerations
Intermolecular channels direct crystal orientation in mineralized collagen
The mineralized collagen fibril is the basic building block of bone, and is commonly pictured as a parallel array of ultrathin carbonated hydroxyapatite (HAp) platelets distributed throughout the collagen. This orientation is often attributed to an epitaxial relationship between the HAp and collagen molecules inside 2D voids within the fibril. Although recent studies have questioned this model, the structural relationship between the collagen matrix and HAp, and the mechanisms by which collagen directs mineralization remain unclear. Here, we use XRD to reveal that the voids in the collagen are in fact cylindrical pores with diameters of ~2 nm, while electron microscopy shows that the HAp crystals in bone are only uniaxially oriented with respect to the collagen. From in vitro mineralization studies with HAp, CaCO3 and γ-FeOOH we conclude that confinement within these pores, together with the anisotropic growth of HAp, dictates the orientation of HAp crystals within the collagen fibril
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