Belonging to the interwar world : Tracing the travelogues of Colin Ross

This article reflects on the results of a two-year research project on German journalist, writer, filmmaker, and lecturer of travelogues as well as self-styled geopolitical expert and Nazi propagandist Colin Ross (1885-1945). Besides a brief portrayal of a career that spanned the two world wars, it elaborates on the project’s most comprehensive research result, its website. Both database and collection of thematic, annotated media objects from Ross’s large output in books, articles, films, and lectures it considers its implications for research on the international dimension of his work. The article presents his career as an opportunity to contribute to an evaluation of what German archivist Hans Booms called the documentary heritage of the countries and regions Ross sojourned: to what extent did the archival traces he and the companies and authorities he contracted and negotiated with contributed to his significance for literary, media or other local histories. The traces of Ross’s journalism, books, film releases, and lectures in Dutch repositories is presented as a case study of the relevance of Booms’s archival notion and a plea for bringing to the fore the local effects of the international traffic of ideas and viewpoints

Lantern readings or "The speech expected of some members of society whenever they open their mouths"

exploratory essay about the under-researched phenomenon of the lantern reading, pre-printed texts that served amateur or inexperienced lecturers during lantern lecture

Showing and telling : film heritage institutes and their performance of public accountability

Een herziene handelseditie van dit proefschrift is verschenen onder dezelfde titel, bij Vernon Press in 2017, ISBN 9781622732401 - This PhD expands on 12 previously published film historical and -archival articles and essays. An extensive introductory text was written to string these articles and essays together and forge them into an argument for improving the performance of film heritage institutes vis-a-vis the public. In the first chapter of that introduction I sketch a general, critical picture of the way publicly funded film heritage institutes tend to use their gatekeeper function to restrict the range of materials given in their care in their public presentations. In the following chapter I present a brief series of case studies, each focusing on an 'uninteresting' archival artifact that is usually not activated, i.e. lifted from the darkness of the vaults into the pubic light. I show how by they can be meaningfully presented by relevant contextualizations. While the case studies were based on my work in a film heritage institute, the next section of the introductory chapter expands my 'personal database' and contains a survey of the public presentations and public information of 24 film heritage institutes worldwide during the month of February 2014, based on their websites. In my evaluation of this survey I conclude that film heritage institutes in their public presentations tend to emphasize more recent works (certainly early cinema is all but absent); that their presentations tend to be technologically inconsistent and the inconsistency unexplained; and that their almost exclusively aesthetic focus tends to be based on tradition rather than research. My findings are theoretically underpinned by (art) sociological considerations, notably from works by Howard Becker, Anthony Giddens, Diana Crane, and Victoria Alexander, and by archival science, notably Hans Booms's concept of functional context (i.e. geographically and historically local contexts that are relevant for the materials in an institute's care)

Belonging to the interwar world : Tracing the travelogues of Colin Ross

This article reflects on the results of a two-year research project on German journalist, writer, filmmaker, and lecturer of travelogues as well as self-styled geopolitical expert and Nazi propagandist Colin Ross (1885-1945). Besides a brief portrayal of a career that spanned the two world wars, it elaborates on the project’s most comprehensive research result, its website. Both database and collection of thematic, annotated media objects from Ross’s large output in books, articles, films, and lectures it considers its implications for research on the international dimension of his work. The article presents his career as an opportunity to contribute to an evaluation of what German archivist Hans Booms called the documentary heritage of the countries and regions Ross sojourned: to what extent did the archival traces he and the companies and authorities he contracted and negotiated with contributed to his significance for literary, media or other local histories. The traces of Ross’s journalism, books, film releases, and lectures in Dutch repositories is presented as a case study of the relevance of Booms’s archival notion and a plea for bringing to the fore the local effects of the international traffic of ideas and viewpoints

Working papers #1: art historian Willem Vogelsang

A ‘reconnaissance report’ prompted by the project’s first case study, art historian Prof. Dr. Willem Vogelsang, It deals with a number of professional contexts of Vogelsang’s work, both as an academic and as a public speaker, in order to get acquainted with various aspects of the illustrated lecture as a medium in the Netherlands during the first half of the 20th century

Working papers #1: art historian Willem Vogelsang

A ‘reconnaissance report’ prompted by the project’s first case study, art historian Prof. Dr. Willem Vogelsang, It deals with a number of professional contexts of Vogelsang’s work, both as an academic and as a public speaker, in order to get acquainted with various aspects of the illustrated lecture as a medium in the Netherlands during the first half of the 20th century

Pharmaceutical and clinical development of phosphonate-based radiopharmaceuticals for the targeted treatment of bone metastases

Therapeutic phosphonate-based radiopharmaceuticals radiolabeled with beta, alpha and conversion electron emitting radioisotopes have been investigated for the targeted treatment of painful bone metastases for >35years. We performed a systematic literature search and focused on the pharmaceutical development, preclinical research and early human studies of these radiopharmaceuticals. The characteristics of an ideal bone-targeting therapeutic radiopharmaceutical are presented and compliance with these criteria by the compounds discussed is verified. The importance of both composition and preparation conditions for the stability and biodistribution of several agents is discussed. Very few studies have described the characterization of these products, although knowledge on the molecular structure is important with respect to in vivo behavior. This review discusses a total of 91 phosphonate-based therapeutic radiopharmaceuticals, of which only six agents have progressed to clinical use. Extensive clinical studies have only been described for (186)Re-HEDP, (188)Re-HEDP and (153)Sm-EDTMP. Of these, (153)Sm-EDTMP represents the only compound with worldwide marketing authorization. (177)Lu-EDTMP has recently received approval for clinical use in India. This review illustrates that a thorough understanding of the radiochemistry of these agents is required to design simple and robust preparation and quality control methods, which are needed to fully exploit the potential benefits of these theranostic radiopharmaceuticals. Extensive biodistribution and dosimetry studies are indispensable to provide the portfolios that are required for assessment before human administration is possible. Use of the existing knowledge collected in this review should guide future research efforts and may lead to the approval of new promising agents

Regional increase in P-glycoprotein function in the blood-brain barrier of patients with chronic schizophrenia: A PET study with [C-11]verapamil as a probe for P-glycoprotein function

P-glycoprotein (P-gp), a major efflux pump in the blood-brain barrier (BBB) has a profound effect on entry of drugs, peptides and other substances into the central nervous system (CNS). The brain's permeability can be negatively influenced by modulation of the transport function of P-gp. Inflammatory mediators play a role in schizophrenia, and may be able to influence the integrity of the BBB, via P-gp modulation. We hypothesized that P-gp function in the BBB is changed in patients with schizophrenia. Positron-emission tomography was used to measure brain uptake of [C-11]verapamil, which is normally extruded from the brain by P-gp. We found that patients with chronic schizophrenia under treatment with antipsychotic drugs compared with healthy controls showed a significant decrease in [C-11]verapamil uptake in the temporal cortex, the basal ganglia, and the amygdala, and amygdalae, and a trend towards a significant decrease was seen throughout the brain. The decrease of [C-11]verapamil uptake correlates with an increased activity of the P-gp pump. Increased P-gp activity may be a factor in drug resistance in schizophrenia, induced by the use of antipsychotic agents. (C) 2010 Elsevier Ireland Ltd. All rights reserved