Search for the magnetic field of the O7.5 III star xi Persei

Cyclical wind variability is an ubiquitous but as yet unexplained feature among OB stars. The O7.5 III(n)((f)) star xi Persei is the brightest representative of this class on the Northern hemisphere. As its prominent cyclical wind properties vary on a rotational time scale (2 or 4 days) the star has been already for a long time a serious magnetic candidate. As the cause of this enigmatic behavior non-radial pulsations and/or a surface magnetic field are suggested. We present a preliminary report on our attempts to detect a magnetic field in this star with high-resolution measurements obtained with the spectropolarimeter Narval at TBL, France during 2 observing runs of 5 nights in 2006 and 5 nights in 2007. Only upper limits could be obtained, even with the longest possible exposure times. If the star hosts a magnetic field, its surface strength should be less than about 300 G. This would still be enough to disturb the stellar wind significantly. From our new data it seems that the amplitude of the known non-radial pulsations has changed within less than a year, which needs further investigation.Comment: 2 pages, 6 figures, contributed poster at IAU Symposium 259 "Cosmic Magnetic Fields: from Planets, to Stars and Galaxies", Tenerife, Spain, November 3-7, 200

Alx1, a member of the Cart1/Alx3/Alx4 subfamily of Paired-class homeodomain proteins, is an essential component of the gene network controlling skeletogenic fate specification in the sea urchin embryo

In the sea urchin embryo, the large micromeres and their progeny function as a critical signaling center and execute a complex morphogenetic program. We have identified a new and essential component of the gene network that controls large micromere specification, the homeodomain protein Alx1. Alx1 is expressed exclusively by cells of the large micromere lineage beginning in the first interphase after the large micromeres are born. Morpholino studies demonstrate that Alx1 is essential at an early stage of specification and controls downstream genes required for epithelial-mesenchymal transition and biomineralization. Expression of Alx1 is cell autonomous and regulated maternally through ß-catenin and its downstream effector, Pmar1. Alx1 expression can be activated in other cell lineages at much later stages of development, however, through a regulative pathway of skeletogenesis that is responsive to cell signaling. The Alx1 protein is highly conserved among euechinoid sea urchins and is closely related to the Cart1/Alx3/Alx4 family of vertebrate homeodomain proteins. In vertebrates, these proteins regulate the formation of skeletal elements of the limbs, face and neck. Our findings suggest that the ancestral deuterostome had a population of biomineral-forming mesenchyme cells that expressed an Alx1-like protein

Inhibition of Acetylcholinesterase by N-Alkylpyridinium and N-Alkylpyridinium-2-aldoxime Salts

The interaction of a series of N-a1kylpyridinium and N-alkylpyridinium- 2-aldoxime salts with bovine erythrocyte acetylcholinesterase was investigated for inhibition of the hydrolysis of the substrates acetylcholine and dimethylaminoethyl acetate. The compounds cause a mixed inhibition of the acetylcholine hydrolysis which is interpreted as an interaction with the free enzyme (competitive component) and with the acetylenzyme (non- competitive component). The results suggest that the compounds have a higher affinity for the free enzyme than for the acetyl- enzyme. Enlargement of the alkyl-group increases the binding capacity to the free enzyme. The aldoxime group hardly effects the binding to the free enzyme, but tends to increase the binding to the acetyl-enzyme. Some results obtained with dimethylaminoethyl acetate support the mechanism of inhibition as proposed from acetylcholine hydrolysis inhibition. In contrast to this mechanism some compounds do not influence or even increase the maximum velocity of the dimethylaminoethyl acetate hydrolysis. It is suggested that a ternary complex of enzyme, substrate and pyridinium compound may be formed from which, in case of dimethylaminoethyl acetate, the enzyme is more rapidly acetylated

Inhibition of Acetylcholinesterase by N-Alkylpyridinium and N-Alkylpyridinium-2-aldoxime Salts

The interaction of a series of N-a1kylpyridinium and N-alkylpyridinium- 2-aldoxime salts with bovine erythrocyte acetylcholinesterase was investigated for inhibition of the hydrolysis of the substrates acetylcholine and dimethylaminoethyl acetate. The compounds cause a mixed inhibition of the acetylcholine hydrolysis which is interpreted as an interaction with the free enzyme (competitive component) and with the acetylenzyme (non- competitive component). The results suggest that the compounds have a higher affinity for the free enzyme than for the acetyl- enzyme. Enlargement of the alkyl-group increases the binding capacity to the free enzyme. The aldoxime group hardly effects the binding to the free enzyme, but tends to increase the binding to the acetyl-enzyme. Some results obtained with dimethylaminoethyl acetate support the mechanism of inhibition as proposed from acetylcholine hydrolysis inhibition. In contrast to this mechanism some compounds do not influence or even increase the maximum velocity of the dimethylaminoethyl acetate hydrolysis. It is suggested that a ternary complex of enzyme, substrate and pyridinium compound may be formed from which, in case of dimethylaminoethyl acetate, the enzyme is more rapidly acetylated

A new catalog of photometric redshifts in the Hubble Deep Field

Using the newly available infrared images of the Hubble Deep Field in the J, H, and K bands and an optimal photometric method, we have refined a technique to estimate the redshifts of 1067 galaxies. A detailed comparison of our results with the spectroscopic redshifts in those cases where the latter are available shows that this technique gives very good results for bright enough objects (AB(8140) < 26.0). From a study of the distribution of residuals (Dz(rms)/(1+z) ~ 0.1 at all redshifts) we conclude that the observed errors are mainly due to cosmic variance. This very important result allows for the assessment of errors in quantities to be directly or indirectly measured from the catalog. We present some of the statistical properties of the ensemble of galaxies in the catalog, and finish by presenting a list of bright high-redshift (z ~ 5) candidates extracted from our catalog, together with recent spectroscopic redshift determinations confirming that two of them are at z=5.34 and z=5.60.Comment: 28 pages, 12PS+4JPEG figures, aaspp style. Accepted for publication in The Astrophysical Journal. The catalog, together with a clickable map of the HDF, Tables 4 and 5 (HTML, LaTeX or ASCII format), and the figures, are available at http://bat.phys.unsw.edu.au/~fsoto/hdfcat.htm

The cholesterol-raising diterpenes from coffee beans increase serum lipid transfer protein activity levels in humans

Cafestol and kahweol–diterpenes present in unfiltered coffee— strongly raise serum VLDL and LDL cholesterol and slightly reduce HDL cholesterol in humans. The mechanism of action is unknown. We determined whether the coffee diterpenes may affect lipoprotein metabolism via effects on lipid transfer proteins and lecithin:cholesterol acyltransferase in a randomized, double-blind cross-over study with 10 healthy male volunteers. Either cafestol (61–64 mg/day) or a mixture of cafestol (60 mg/day) and kahweol (48–54 mg/day) was given for 28 days. Serum activity levels of cholesterylester transfer protein, phospholipid transfer protein and lecithin:cholesterol acyltransferase were measured using exogenous substrate assays. Relative to baseline values, cafestol raised the mean (±S.D.) activity of cholesterylester transfer protein by 18±12% and of phospholipid transfer protein by 21±14% (both P<0.001). Relative to cafestol alone, kahweol had no significant additional effects. Lecithin:cholesterol acyltransferase activity was reduced by 11±12% by cafestol plus kahweol (P=0.02). It is concluded that the effects of coffee diterpenes on plasma lipoproteins may be connected with changes in serum activity levels of lipid transfer proteins

Galaxy Masses

Galaxy masses play a fundamental role in our understanding of structure formation models. This review addresses the variety and reliability of mass estimators that pertain to stars, gas, and dark matter. The different sections on masses from stellar populations, dynamical masses of gas-rich and gas-poor galaxies, with some attention paid to our Milky Way, and masses from weak and strong lensing methods, all provide review material on galaxy masses in a self-consistent manner.Comment: 145 pages, 28 figures, to appear in Reviews of Modern Physics. Figure 22 is missing here, and Figs. 15, 26-28 are at low resolution. This version has a slightly different title and some typos fixed in Chapter 5. For the full review with figures, please consult: http://www.astro.queensu.ca/~courteau/GalaxyMasses_28apr2014.pd

Regulatory Dynamics on Random Networks: Asymptotic Periodicity and Modularity

We study the dynamics of discrete-time regulatory networks on random digraphs. For this we define ensembles of deterministic orbits of random regulatory networks, and introduce some statistical indicators related to the long-term dynamics of the system. We prove that, in a random regulatory network, initial conditions converge almost surely to a periodic attractor. We study the subnetworks, which we call modules, where the periodic asymptotic oscillations are concentrated. We proof that those modules are dynamically equivalent to independent regulatory networks.Comment: 23 pages, 3 figure