2,056 research outputs found
Universality of Shot-Noise in Multiterminal Diffusive Conductors
We prove the universality of shot-noise in multiterminal diffusive conductors
of arbitrary shape and dimension for purely elastic scattering as well as for
hot electrons. Using a Boltzmann-Langevin approach we reduce the calculation of
shot-noise correlators to the solution of a diffusion equation. We show that
shot-noise in multiterminal conductors is a non-local quantity and that
exchange effects can occur without quantum phase coherence even at zero
electron temperature. Concrete numbers for shot-noise are given that can be
tested experimentally.Comment: 4 double-column pages, REVTeX, 1 eps figure embedded with eps
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Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2.
Lamins B1 and B2 (B-type lamins) have very similar sequences and are expressed ubiquitously. In addition, both Lmnb1- and Lmnb2-deficient mice die soon after birth with neuronal layering abnormalities in the cerebral cortex, a consequence of defective neuronal migration. The similarities in amino acid sequences, expression patterns, and knockout phenotypes raise the question of whether the two proteins have redundant functions. To investigate this topic, we generated "reciprocal knock-in mice"-mice that make lamin B2 from the Lmnb1 locus (Lmnb1(B2/B2)) and mice that make lamin B1 from the Lmnb2 locus (Lmnb2(B1/B1)). Lmnb1(B2/B2) mice produced increased amounts of lamin B2 but no lamin B1; they died soon after birth with neuronal layering abnormalities in the cerebral cortex. However, the defects in Lmnb1(B2/B2) mice were less severe than those in Lmnb1-knockout mice, indicating that increased amounts of lamin B2 partially ameliorate the abnormalities associated with lamin B1 deficiency. Similarly, increased amounts of lamin B1 in Lmnb2(B1/B1) mice did not prevent the neurodevelopmental defects elicited by lamin B2 deficiency. We conclude that lamins B1 and B2 have unique roles in the developing brain and that increased production of one B-type lamin does not fully complement loss of the other
The valuation of clean spread options: linking electricity, emissions and fuels
The purpose of the paper is to present a new pricing method for clean spread options, and to illustrate its main features on a set of numerical examples produced by a dedicated computer code. The novelty of the approach is embedded in the use of a structural model as opposed to reduced-form models which fail to capture properly the fundamental dependencies between the economic factors entering the production process
Proarrhythmic proclivity of left-stellate ganglion stimulation in a canine model of drug-induced long-QT syndrome type 1
Background
Left-stellate ganglion stimulation (LSGS) can modify regional dispersion of ventricular refractoriness, promote triggered activity, and reduce the threshold for ventricular fibrillation (VF). Sympathetic hyperactivity precipitates torsades de pointes (TdP) and VF in susceptible patients with long-QT syndrome type 1 (LQT1). We investigated the electromechanical effects of LSGS in a canine model of drug-induced LQT1, gaining novel arrhythmogenic insights.
Methods
In nine mongrel dogs, the left and right stellate ganglia were exposed for electrical stimulation. ECG, left- and right-ventricular endocardial monophasic action potentials (MAPs) and pressures (LVP, RVP) were recorded. The electromechanical window (EMW; Q to LVP at 90% relaxation minus QT interval) was calculated. LQT1 was mimicked by infusion of the KCNQ1/IKs blocker HMR1556.
Results
At baseline, LSGS and right-stellate ganglion stimulation (RSGS) caused similar heart-rate acceleration and QT shortening. Positive inotropic and lusitropic effects were more pronounced under LSGS than RSGS. IKs blockade prolonged QTc, triggered MAP-early afterdepolarizations (EADs) and rendered the EMW negative, but no ventricular tachyarrhythmias occurred. Superimposed LSGS exaggerated EMW negativity and evoked TdP in 5/9 dogs within 30 s. Preceding extrasystoles originated mostly from the outflow-tracts region. TdP deteriorated into therapy-refractory VF in 4/5 animals. RSGS did not provoke TdP/VF.
Conclusions
In this model of drug-induced LQT1, LSGS readily induced TdP and VF during repolarization prolongation and MAP-EAD generation, but only if EMW turned from positive to very negative. We postulate that altered mechano-electric coupling can exaggerate regional dispersion of refractoriness and facilitates ventricular ectopy
Strong Balmer lines in old stellar populations: No need for young ages in ellipticals?
Comparing models of Simple Stellar Populations (SSP) with observed line
strengths generally provides a tool to break the age-metallicity degeneracy in
elliptical galaxies. Due to the wide range of Balmer line strengths observed,
ellipticals have been interpreted to exhibit an appreciable scatter in age. In
this paper, we analyze Composite Stellar Population models with a simple mix of
an old metal-rich and an old metal-poor component. We show that these models
simultaneously produce strong Balmer lines and strong metallic lines without
invoking a young population. The key to this result is that our models are
based on SSPs that better match the steep increase of Hbeta in metal-poor
globular clusters than models in the literature. Hence, the scatter of Hbeta
observed in cluster and luminous field elliptical galaxies can be explained by
a spread in the metallicity of old stellar populations. We check our model with
respect to the so-called G-dwarf problem in ellipticals. For a galaxy subsample
covering a large range in UV-V colors we demonstrate that the addition of an
old metal-poor subcomponent does not invalidate other observational constraints
like colors and the flux in the mid-UV.Comment: Accepted for publication in ApJ Main Journal, 9 pages, 5 figure
Structural Evidence for Environment-Driven Transformation of the Blue Galaxies in Local Abell Clusters - A85, A496, and A754
We compare V-band structural properties of cluster and field galaxies, to
test whether much of the current cluster membership resulted from the
transformation of infalling spirals into red early types. We use 140 galaxies
from 3 z<0.6 Abell clusters (A85,A496,A754 - spectroscopic membership) with
blue colors, and compare them to 80 field galaxies with similar colors and
luminosities. Our previous work (McIntosh et al. 2004, ApJ submitted) shows
that the blue galaxies in these local clusters are a recently infalling
population that has yet to encounter the dense core. We quantify galaxy
internal structure from 2D B/D decompositions using GIM2D. We observe
structural differences between blue galaxies in clusters, compared to the
field. Most blue cluster members are physically smaller and fainter than their
field counterparts. At a matched size and luminosity, recent arrivals are
smoother in appearance, yet their total light is as disk-dominated as in normal
field spirals. Moreover, 50% of blue cluster galaxies have blue cores or
globally blue color profiles, in contrast with field spirals that have
typically red color gradients. Without environment dependent evolution outside
of cluster cores, we expect blue disk galaxies in clusters and the field to
have similar morphologies, sizes, and color gradients. We show conclusively
that galaxy properties do reflect the environment in which the galaxy is found.
The data show that the transformation of accreted galaxies is not confined to
the dense cluster core. The overall properties of bluer cluster galaxies are
best explained by environment-driven transformation of accreted field spirals,
and our results suggest that the processes that govern color and morphological
evolution occur separately. (abridged)Comment: Accepted for publication in ApJ, 23 pages, Latex using
emulateapj5.sty and onecolfloat.sty (included), 15 figures, version with full
resolution Figs. 2 and 5 at
http://www.astro.umass.edu/~dmac/Papers/transf.hires.ps Substantial revisions
of Introduction and Discussion; extensive minor changes throughout paper
following recommendations by referee; conclusions unchanged except for
removal of pre-processing interpretatio
The accretion origin of the Milky Way's stellar halo
We have used data from the Sloan Digital Sky Survey (SDSS) Data Release 5 to
explore the overall structure and substructure of the stellar halo of the Milky
Way using about 4 million color-selected main sequence turn-off stars. We fit
oblate and triaxial broken power-law models to the data, and found a `best-fit'
oblateness of the stellar halo 0.5<c/a<0.8, and halo stellar masses between
Galactocentric radii of 1 and 40kpc of (3.7+/-1.2)x10^8 M_sun. The density
profile of the stellar halo is approximately r^{-3}; it is possible that the
power law slope is shallower inside 20kpc and steeper outside that radius. Yet,
we found that all smooth and symmetric models were very poor fits to the
distribution of stellar halo stars because the data exhibit a great deal of
spatial substructure. We quantified deviations from a smooth oblate/triaxial
model using the RMS of the data around the model profile on scales >~100pc,
after accounting for the (known) contribution of Poisson uncertainties. The
fractional RMS deviation of the actual stellar distribution from any smooth,
parameterized halo model is >~40%: hence, the stellar halo is highly
structured. We compared the observations with simulations of galactic stellar
halos formed entirely from the accretion of satellites in a cosmological
context by analysing the simulations in the same way as the data. While the
masses, overall profiles, and degree of substructure in the simulated stellar
halos show considerable scatter, the properties and degree of substructure in
the Milky Way's halo match well the properties of a `typical' stellar halo
built exclusively out of the debris from disrupted satellite galaxies. Our
results therefore point towards a picture in which an important fraction of the
Milky Way's stellar halo has been accreted from satellite galaxies.Comment: Submitted to the Astrophysical Journal. 14 pages; 11 figure
Hearing Impairment Is Associated with Smaller Brain Volume in Aging
Although recent studies show that age-related hearing impairment is associated with cerebral changes, data from a population perspective are still lacking. Therefore, we studied the relation between hearing impairment and brain volume in a large elderly cohort. From the population-based Rotterdam Study, 2,908 participants (mean age 65 years, 56% female) underwent a pure-tone audiogram to quantify hearing impairment. By performing MR imaging of the brain we quantified global and regional brain tissue volumes (total brain volume, gray matter volume, white matter (WM) volume, and lobe-specific volumes). We used multiple linear regression models, adjusting for age, sex, head size, time between hearing test and MR imaging, and relevant cognitive and cardiovascular covariates. Furthermore, we performed voxel-based morphometry to explore sub-regional differences. We found that a higher pure-tone threshold was associated with a smaller total brain volume [difference in standardized brain volume per decibel increase in hearing threshold in the age-sex adjusted model: -0.003 (95% confidence interval -0.004; -0.001)]. Specifically, WM volume was associated. Both associations were more pronounced in the lower frequencies. All associations were consistently present in all brain lobes in the lower frequencies and in most lobes in the higher frequencies, and were independent of cognitive function and cardiovascular risk factors. In voxel-based analyses we found associations of hearing impairment with smaller white volumes and some smaller and larger gray volumes, yet these were statistically non-significant. Our findings demonstrate that hearing impairment in elderly is related to smaller total brain volume, independent of cognition and cardiovascular ris
A 6-item scale for overall, emotional, and social loneliness: Confirmatory tests on survey data
Loneliness is an indicator of social well-being and pertains to the feeling of missing an intimate relationship (emotional loneliness) or missing a wider social network (social loneliness). The 11-item De Jong Gierveld Loneliness Scale has proved to be a valid and reliable measurement instrument for overall, emotional, and social loneliness, although its length has sometimes rendered it difficult to use in large surveys. In this study, the authors empirically tested a shortened version of the scale on data from two surveys (N = 9,448). Confirmatory factor analyses confirmed the specification of two latent factors. Congruent validity and the relationship with determinants (partner status, health) proved to be optimal. The 6-item De Jong Gierveld Loneliness Scale is a reliable and valid measurement instrument for overall, emotional, and social loneliness that is suitable for large surveys
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