Local positive feedback and the persistence and recovery of fringe Avicennia marina (Forssk.) Vierh. mangroves

While mangrove restoration efforts are reasonably successful, failure often occurs in high wave energy situations. Due to differences in wave energy, seedling mortality rates vary strongly with position on the intertidal flat between high water spring and high water neap elevations. However, a local positive feedback can be present between the pneumatophores of adult mangroves and the survival of mangrove seedlings to trigger recovery. In this study, a mangrove population of Avicennia marina is modelled to determine the effects of seedling mortality and local positive feedback on mangrove recovery. The model uses life history data and dispersal to simulate population dynamics. The mangrove range limits are determined by high water spring and high water neap levels. The results indicate that within these limits mangrove populations with life-history parameter values as derived from literature are indeed capable of fast growth under conditions with low seedling mortality. Local positive feedback has then a small positive influence on population recovery after mangrove loss. If, however, mortality rates increase, such as in high wave energy situations, the importance of a positive feedback increases. The model shows that a positive feedback may, given high seedling mortality rates, be an important factor for mangrove recovery. While a positive feedback may enable mangrove persistence in unfavourable conditions, destruction of adult mangroves can remove the positive feedback, which would render the system uninhabitable and practically prohibits reforestation of such areas. The model results and the presence of positive feedbacks and their importance for population dynamics in harsh conditions indicate that investigating and understanding possible feedbacks could be crucial for successful restoration effort

Factorization of Seiberg-Witten Curves and Compactification to Three Dimensions

We continue our study of nonperturbative superpotentials of four-dimensional N=2 supersymmetric gauge theories with gauge group U(N) on R^3 x S^1, broken to N=1 due to a classical superpotential. In a previous paper, hep-th/0304061, we discussed how the low-energy quantum superpotential can be obtained by substituting the Lax matrix of the underlying integrable system directly into the classical superpotential. In this paper we prove algebraically that this recipe yields the correct factorization of the Seiberg-Witten curves, which is an important check of the conjecture. We will also give an independent proof using the algebraic-geometrical interpretation of the underlying integrable system.Comment: laTeX, 14 pages, uses AMSmat

Renal clearance of the thyrotropin-releasing hormone-like peptide pyroglutamyl-glutamyl-prolineamide in humans

TRH-like peptides have been identified that differ from TRH (pGlu-His-ProNH2) in the middle amino acid. We have estimated TRH-like immunoreactivity (TRH-LI) in human serum and urine by RIA with TRH-specific antiserum 8880 or with antiserum 4319, which binds most peptides with the structure pGlu-X-ProNH2. TRH was undetectable in serum (< 25 pg/mL), but TRH-LI was detected with antiserum 4319 in serum of 27 normal subjects, 21 control patients, and 12 patients with carcinoid tumors (range 17-45, 5-79, and 18-16,600 pg/mL, respectively). Because serum was kept for at least 2 h at room temperature, which causes degradation of TRH, pGlu-Phe-ProNH2, and pGlu-Tyr-ProNH2, serum TRH-LI is not caused by these peptides. On high-performance liquid chromatography, serum TRH-LI coeluted with pGlu-Glu-ProNH2 (< EEP-NH2), a peptide produced in, among others, the prostate. Urine of normals and control patients also contained TRH-LI (range 1.14-4.97 and 0.24-5.51 ng/mL, respectively), with similar levels in males and females. TRH represented only 2% of urinary TRH-LI, and anion-exchange chromatography and high-performance liquid chromatography revealed that most TRH-LI in urine was < EEP-NH2. In patients with carcinoid tumors, increased urinary TRH-LI levels were noted (range 1.35-962.4 ng/mL). Urinary TRH-LI correlated positively with urinary creatinine, and the urinary clearance rate of TRH-LI was similar to the glomerular filtration rate. In addition, serum TRH-LI was increased in 17 hemodialysis patients (43-373 pg/mL). This suggests that serum < EEP-NH2 is cleared by glomerular filtration wit

Renal clearance of the thyrotropin-releasing hormone-like peptide pyroglutamyl-glutamyl-prolineamide in humans

TRH-like peptides have been identified that differ from TRH (pGlu-His-ProNH2) in the middle amino acid. We have estimated TRH-like immunoreactivity (TRH-LI) in human serum and urine by RIA with TRH-specific antiserum 8880 or with antiserum 4319, which binds most peptides with the structure pGlu-X-ProNH2. TRH was undetectable in serum (< 25 pg/mL), but TRH-LI was detected with antiserum 4319 in serum of 27 normal subjects, 21 control patients, and 12 patients with carcinoid tumors (range 17-45, 5-79, and 18-16,600 pg/mL, respectively). Because serum was kept for at least 2 h at room temperature, which causes degradation of TRH, pGlu-Phe-ProNH2, and pGlu-Tyr-ProNH2, serum TRH-LI is not caused by these peptides. On high-performance liquid chromatography, serum TRH-LI coeluted with pGlu-Glu-ProNH2 (< EEP-NH2), a peptide produced in, among others, the prostate. Urine of normals and control patients also contained TRH-LI (range 1.14-4.97 and 0.24-5.51 ng/mL, respectively), with similar levels in males and females. TRH represented only 2% of urinary TRH-LI, and anion-exchange chromatography and high-performance liquid chromatography revealed that most TRH-LI in urine was < EEP-NH2. In patients with carcinoid tumors, increased urinary TRH-LI levels were noted (range 1.35-962.4 ng/mL). Urinary TRH-LI correlated positively with urinary creatinine, and the urinary clearance rate of TRH-LI was similar to the glomerular filtration rate. In addition, serum TRH-LI was increased in 17 hemodialysis patients (43-373 pg/mL). This suggests that serum < EEP-NH2 is cleared by glomerular filtration with little tubular resorption. The possible role of the prostate as a source of urinary TRH-LI was evaluated in 11 men with prostate cancer, showing a 25% decrease in urinary TRH-LI excretion after prostatectomy (0.19 +/- 0.02 vs. 0.15 +/- 0.01 ng/mumol creatinine, mean +/- SEM). However, TRH-LI was similar in spontaneously voided urine and in urine obtained through a nephrostomy cannula from 16 patients with unilateral urinary tract obstruction (0.15 +/- 0.01 vs. 0.14 +/- 0.01 ng/mumol creatinine). These data indicate that: 1) TRH-LI in human serum represents largely < EEP-NH2, which is cleared by renal excretion; 2) part of urinary < EEP-NH2 is derived from prostatic secretion into the blood and not directly into urine; and 3) urinary < EEP-NH2 can be used as marker for carcinoid tumors

Hypermutation of Immunoglobulin Genes in Memory B Cells of DNA Repair–deficient Mice

To investigate the possible involvement of DNA repair in the process of somatic hypermutation of rearranged immunoglobulin variable (V) region genes, we have analyzed the occurrence, frequency, distribution, and pattern of mutations in rearranged Vλ1 light chain genes from naive and memory B cells in DNA repair–deficient mutant mouse strains. Hypermutation was found unaffected in mice carrying mutations in either of the following DNA repair genes: xeroderma pigmentosum complementation group (XP)A and XPD, Cockayne syndrome complementation group B (CSB), mutS homologue 2 (MSH2), radiation sensitivity 54 (RAD54), poly (ADP-ribose) polymerase (PARP), and 3-alkyladenine DNA-glycosylase (AAG). These results indicate that both subpathways of nucleotide excision repair, global genome repair, and transcription-coupled repair are not required for somatic hypermutation. This appears also to be true for mismatch repair, RAD54-dependent double-strand–break repair, and AAG-mediated base excision repair

Nonperturbative Superpotentials and Compactification to Three Dimensions

We consider four-dimensional N=2 supersymmetric gauge theories with gauge group U(N) on R^3 x S^1, in the presence of a classical superpotential. The low-energy quantum superpotential is obtained by simply replacing the adjoint scalar superfield in the classical superpotential by the Lax matrix of the integrable system that underlies the 4d field theory. We verify in a number of examples that the vacuum structure obtained in this way matches precisely that in 4d, although the degrees of freedom that appear are quite distinct. Several features of 4d field theories, such as the possibility of lifting vacua from U(N) to U(tN), become particularly simple in this framework. It turns out that supersymmetric vacua give rise to a reduction of the integrable system which contains information about the field theory but also about the Dijkgraaf-Vafa matrix model. The relation between the matrix model and the quantum superpotential on R^3 x S^1 appears to involve a novel kind of mirror symmetry.Comment: LaTeX, 45 pages, uses AmsMath, minor correction, reference adde