FLECS, a flexible coupling shell, application to fluid-structure interaction

Numerical simulations involving multiple, physically different domains can be solved effectively by coupling simulation programs, or solvers. The coordination of the different solvers is commonly handled by a coupling shell. A coupling shell synchronizes the execution of the solvers and handles the transfer of data from one physical domain to another. In this paper, we introduce Flecs, a flexible coupling shell, designed for implementing and applying an interface for multidisciplinary simulations with superior accuracy. The aim is not to achieve the best possible efficiency or to support a large feature set, but to provide a flexible platform for developing new data transfer algorithms and coupling schemes

Strings in extremal BTZ black holes

We study the spectrum of the worldsheet theory of the bosonic closed string in the massless and extremal rotating BTZ black holes. We use a hyperbolic Wakimoto representation of the SL(2,R) currents to construct vertex operators for the string modes on these backgrounds. We argue that there are tachyons in the twisted sector, but these are not localised near the horizon. We study the relation to the null orbifold in the limit of vanishing cosmological constant. We also discuss the problem of extending this analysis to the supersymmetric case.Comment: 20 pages, no figure

Testing a Prototype Adsorption Cooler in a Research Dwelling

Cooling with heat is hot. Demand for cooling often coincides with the supply of solar heat. This makes thermally driven chillers (TDC's) in combination with solar collectors interesting for improving the energy efficiency of comfort cooling. Several TDC's are already available on the market. Only small scale (comfort) TDC's for applications in dwellings are not commercially available yet. This is why the Energy research Centre of the Netherlands (ECN) developed a prototype adsorption chiller, based on silica gel water, with a nominal cooling capacity of 2.5 kW. This paper will explain the working principle of the water-silica adsorption chiller, and will summarize executed measurements and their results. These results show that the choice of water and silica is successful and that the technology is ready to be commercialised

Validity of self-reported causes of subfertility

The authors assessed the accuracy of cause(s) of subfertility as reported by women in a self-administered questionnaire in comparison with medical record information, in a nationwide cohort study of women receiving in vitro fertilization treatment in the Netherlands (n = 9,164) between 1983 and 1995. Validity was expressed as sensitivity and specificity, and reliability was expressed by the kappa statistic and overall agreement between self-reports and medical records for various subfertility categories. The sensitivity for subfertility attributed to tubal, male, hormonal, cervical, uterine, and idiopathic factors and for endometriosis was 84%, 78%, 65%, 40%, 46%, 59%, and 83%, respectively. The corresponding kappas were 0.79, 0.71, 0.38, 0.34, 0.13, 0.50, and 0.52, respectively. For 54% of all women who reported two or more causes of subfertility, the medical record revealed only one major factor. Conversely, for 43% of all women whose subfertility was attributed to two or more major factors in the record, only one factor was reported by the women. Older age at the time of filling out the questionnaire, low educational level, long duration of subfertility, and pre-in vitro fertilization treatment were associated with less accurate reporting. The results indicate that the validity of self-reports for tubal and male subfertility is satisfactory. For unexplained subfertility, the validity is moderate; for other causes of subfertility and when two causes of subfertility play a role, the validity is low. Copyrigh

On the Boundary Dynamics of Chern-Simons Gravity

We study Chern-Simons theory with a complex G_C or a real G x G gauge group on a manifold with boundary - this includes Lorentzian and Euclidean (anti-) de Sitter (E/A)dS gravity for G=SU(2) or G=SL(2,R). We show that there is a canonical choice of boundary conditions that leads to an unambiguous, fully covariant and gauge invariant, off-shell derivation of the boundary action - a G_C/G or G WZW model, coupled in a gauge invariant way to the boundary value of the gauge field. In particular, for (E/A)dS gravity, the boundary action is a WZW model with target space (E/A)dS_3, reminiscent of a worldsheet for worldsheet mechanism. We discuss in some detail the properties of the boundary theories that arise and we confront our results with various related constructions in the literature.Comment: 22 pages, LaTeX2e, v2: JHEP3.cls, references and a footnote adde

Tyrosine kinase inhibitor resistance in de novo BCR::ABL1–positive BCP-ALL beyond kinase domain mutations

A better understanding of ABL1 kinase domain mutation–independent causes of tyrosine kinase inhibitor (TKI) resistance is needed for BCR::ABL1–positive B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Although TKIs have dramatically improved outcomes, a subset of patients still experiences relapsed or refractory disease. We aimed to identify potential biomarkers of intrinsic TKI resistance at diagnosis in samples from 32 pediatric and 19 adult patients with BCR::ABL1–positive BCP-ALL. Reduced ex vivo imatinib sensitivity was observed in cells derived from newly diagnosed patients who relapsed after combined TKI and chemotherapy treatment compared with cells derived from patients who remained in continuous complete remission. We observed that ex vivo imatinib resistance was inversely correlated with the amount of (phosphorylated) BCR::ABL1/ABL1 protein present in samples that were taken at diagnosis without prior TKI exposure. This suggests an intrinsic cause of TKI resistance that is independent of functional BCR::ABL1 signaling. Simultaneous deletions of IKZF1 and CDKN2A/B and/or PAX5 (IKZF1plus), as well as deletions of PAX5 alone, were related to ex vivo imatinib resistance. In addition, somatic lesions involving ZEB2, SETD2, SH2B3, and CRLF2 were associated with reduced ex vivo imatinib sensitivity. Our data suggest that the poor prognostic value of IKZF1(plus) deletions is linked to intrinsic mechanisms of TKI resistance other than ABL1 kinase domain mutations in newly diagnosed pediatric and adult BCR::ABL1–positive BCP-ALL.</p