Simulation of a fully coupled 3D glacial isostatic adjustment - ice sheet model for the Antarctic ice sheet over a glacial cycle

Glacial isostatic adjustment (GIA) has a stabilizing effect on the evolution of the Antarctic ice sheet by reducing the grounding line migration following ice melt. The timescale and strength of this feedback depends on the spatially varying viscosity of the Earth's mantle. Most studies assume a relatively long and laterally homogenous response time of the bedrock. However, the mantle viscosity is spatially variable, with a high mantle viscosity beneath East Antarctica and a low mantle viscosity beneath West Antarctica. For this study, we have developed a new method to couple a 3D GIA model and an ice sheet model to study the interaction between the solid Earth and the Antarctic ice sheet during the last glacial cycle. With this method, the ice sheet model and GIA model exchange ice thickness and bedrock elevation during a fully coupled transient experiment. The feedback effect is taken into account with a high temporal resolution, where the coupling time steps between the ice sheet and GIA model are 5000 years over the glaciation phase and vary between 500 and 1000 years over the deglaciation phase of the last glacial cycle. During each coupling time step, the bedrock elevation is adjusted at every ice sheet model time step, and the deformation is computed for a linearly changing ice load. We applied the method using the ice sheet model ANICE and a 3D GIA finite element model. We used results from a regional seismic model for Antarctica embedded in the global seismic model SMEAN2 to determine the patterns in the mantle viscosity. The results of simulations over the last glacial cycle show that differences in mantle viscosity of an order of magnitude can lead to differences in the grounding line position up to 700gkm and to differences in ice thickness of the order of 2gkm for the present day near the Ross Embayment. These results underline and quantify the importance of including local GIA feedback effects in ice sheet models when simulating the Antarctic ice sheet evolution over the last glacial cycle

Поліваріантний вплив біоактивної води Нафтуся на секрецію шлунка і пошкодження його слизової за умов перев’язки воротаря у щурів

Употребление крысами-самцами в течении 10-11 дней биоактивной воды Нафтуся вызывает в 72% случаев увеличение секреции кислоты желудком в условиях лигирования привратника. У 17% крыс кислотообразование не отличается от такового у контрольных животных, употреблявших водопроводную воду, а у 11% крыс констатирован кислотоингибиторный эффект биоактивной воды Нафтуся. Обнаружена инверсная связь между ацидогенезом и выделением гастрина в кровь и полость желудка, а также выраженностью язвенных повреждений его слизистой.The use rats-males in a flow 10-11 days of bioactive water Naftussya cause in 72% cases increase of secretion of acid by stomach in the conditions of ligating of pylorus. For 17% rats acid secretion does not differ from such for control animals, using a tapwater, and for 11% rats the inhibiting effect is established. Found out inverse relationship between acid secretion and secretion of gastrin in blood and cavity of stomach, and also expressed of ulcerous damages to his mucous membrane

Pharmacogenomic insights into treatment and management of statin-induced myopathy

Although statins are generally well tolerated, the most common adverse drug reaction from statin therapy is myopathy. This article reviews the current pharmacogenomic knowledge of statin-induced myopathy. Furthermore, we will discuss the importance of recent pharmacogenetic advances for the treatment and management of statin-induced myopathy. Variation in the SLCO1B1 gene is associated with increased incidence of statin-induced myopathy, particularly with simvastatin and less so with other statins. If different pharmacokinetic enzymes and transporters are responsible for susceptibility to myopathy, this may explain differences in the occurrence of statin-induced myopathy in individual patients. Genotyping in patients suffering from statin-induced myopathy may help to personalize the choice of statin for the lowest chance of developing myopathy

The transient response of ice volume to orbital forcing during the warm Late Pliocene

Examining the nature of ice sheet and sea level response to past episodes of enhanced greenhouse gas forcing may help constrain future sea level change. Here, for the first time, we present the transient nature of ice sheets and sea level during the late Pliocene. The transient ice sheet predictions are forced by multiple climate snapshots derived from a climate model set up with late Pliocene boundary conditions, forced with different orbital forcing scenarios appropriate to two Marine Isotope Stages (MISs), MIS KM5c, and K1. Our results indicate that during MIS KM5c both the Antarctic and Greenland ice sheets contributed to sea level rise relative to present and were relatively stable. Insolation forcing between the hemispheres was out of phase during MIS K1 and led to an asynchronous response of ice volume globally. Therefore, when variations of precession were high, inferring the behavior of ice sheets from benthic isotope or sea level records is complex

Functional Outcome and Patient Satisfaction after Displaced Intra-articular Calcaneal Fractures: A Comparison Among Open, Percutaneous, and Nonoperative Treatment

The aim of the present study was to compare the outcomes of patients with a displaced calcaneal fracture treated by open reduction and internal fixation (ORIF), percutaneous treatment, or nonoperative methods. A retrospective cohort study was conducted at a level I trauma center of patients with a displaced intra-articular calcaneal fracture treated from January 1, 2002 to December 31, 2011. The patient-reported outcome measures included the Foot Function Index, American Orthopaedic Foot and Ankle Society hindfoot scale, Short Form-36, the EQ-5D from the EuroQol Group, and a 10-point visual analog scale. Clinical data were collected from 169 patients, and questionnaires were obtained from 78 patients (18 nonoperatively, 27 ORIF, and 33 percutaneously). The late intervention rate was significantly greater in the percutaneous group (n = 18; 30%) than in the ORIF group (n = 6; 12%) or the nonoperative group (n = 8; 13%; p = .030). Significantly more disability was reported in the nonoperative group (median Foot Function Index score, 40 points) than in the ORIF group (median, 16 points; p = .010) or in the percutaneous group (median, 21 points; p = .034). In conclusion, the operatively treated patients (ORIF and percutaneous treatment) reported better functional outcome scores (Foot Function Index and American Orthopaedic Foot and Ankle Society hindfoot scale) than did the nonoperatively treated patients