Pengaruh Suhu Terhadap Stabilitas Serta Penetapan Kadar Tablet Furosemida Menggunakan Spektrofotometer Uv-vis

Stability is the ability of product to maintain its nature and characteristics similar to itsorigin during storage and use period. Furosemide is one of drugs product that works as diuretic.The aim of this research was to study the effect of temperature on furosemide stability. Themethod using in this research is factorial Complete Random design. There are two factors in thisresearch,factor A is temperature (40oC, 50 oC, and 60 oC) and factor B are period (60, 120 and180 minutes). There are three samples in this research. Analysis of furosemide content usingSpectrophotometer UV-Vis at λ = 271 nm. Obtained data were analyzed using spss ver. 20. Thedifferences between variable were statistical analyzed. The result shows that the decreasing offurosemide in tablet starts at temperature 50°Cafter60minutes heating for sample A and C.Sample B decrease at temperature 50°C after 120 minutes heating

Pengaruh Suhu Terhadap Stabilitas Berbagai Produk Tablet Nifedipin

Drug storage at heat air condition, high humidity room, and exposed with light lead todrug degradation. Temperature changes is one of external factor cause unstability ofpharmaceutical product.The purpose of this research is to examine the effect of temperature onnifedipin stability. The method using in this research is factorial Complete Random design.There are two factors. Factor A is temperature(40oC, 50 oC, and 60 oC) and factor B are period(60, 120 and 180 minutes). There are three samples in this research research. Analysis ofnifedipin content using Spectrophotometer UV-Vis. Obtained data were analyzed using spss ver.20. The differences between variable were statistical analyzed. The results shows that sample Aat temperature 60 oC, after 180 minutes treatment decrease to 86,47%, Sample B 86,43%, andsample C 85,66%, respectively. Temperature significantly effect on the stability of nifedipin(p<0,05)