Neighbourhood identity helps residents cope with residential diversification: contact in increasingly mixed neighbourhoods of Northern Ireland

Research on residential diversification has mainly focused on its negative impacts upon community cohesion and positive effects on intergroup relations. However, these analyses ignore how neighbourhood identity can shape the consequences of diversification among residents. Elsewhere, research using the Applied Social Identity Approach (ASIA) has demonstrated the potential for neighbourhood identity to provide social and psychological resources to cope with challenges. The current paper proposes a novel model whereby these ‘Social Cure’ processes can enable residents to cope with the specific challenges of diversification. We present two studies in support of this model, each from the increasingly religiously desegregated society of post-conflict Northern Ireland. Analysis of the 2012 ‘Northern Ireland Life and Times’ survey shows that across Northern Ireland, neighbourhood identity impacts positively upon both wellbeing and intergroup attitudes via a reduction in intergroup anxiety. A second custom-designed survey of residents in a newly-mixed area of Belfast shows that neighbourhood identification predicts increased wellbeing, reduced intergroup anxiety and reduced prejudice, independently of group norms and experiences of contact. For political psychologists, our evidence suggests a reformulation of the fundamental question of ‘what effects does residential mixing have on neighbourhoods?’ to ‘how can neighbourhood communities support residents to collectively cope with contact?’

TH2 cytokines profile in severe adult atopic dermatitis [PROFILO DI CITOCHINE A TIPO TH2 IN CORSO DI DERMATITE ATOPICA GRAVE DELL'ADULTO]

Atopic dermatitis is a disorder in which both type I and type IV reactions are involved. The disease is characterized by eczematous lesions and an aspecific infiltrate, often rich in eosinophils. Inflammatory infiltrate is constituted of T cells of the TH1 subset, but many authors showed that the TH2 subtype is important in the early phase of the disease. On the basis of our and of other group studies we investigated, at a molecular level, the mRNA expression of IL-4, IL-5, IL-2 and IFN-γ, in order to define the immunological pattern of the inflammatory infiltrate. IL-2 and IFN-γ are important mediators of delayed immunity, whereas IL-4 and IL-5 are involved especially in early immunity mechanisms, but can also participate in type IV reaction. Interleukin-4 and IL-5 are both produced by the T helper-2 lymphocyte subset. On the other hand the TH1 subset produces IL-2 and IFN-γ. IL-4 and IL-5 have many functions that could be summarized in eosinophils chemoattraction and maturation, and support to immunoglobulin-E production. IL-4 and IFN-γ have opposite functions on IgE production and are counter regulatory each other. 11 patients affected by atopic dermatitis and 5 normal patients have been biopsied. Biopsies and blood samples were taken within 48 hours from the appearance of new lesions and snap frozen in liquid nitrogen. Messenger RNA was extracted from biopsies, reverse transcribed and amplified. β-actin was used as a semiquantitative control. All patients showed a TH2-like cytokine pattern with IL-4 and IL-5 expression in both blood and skin samples. Two patients, biopsied several days later than the others, showed a reduction of IL-4 and IL-5 with an increased production of IL-2 and IFN-γ. We suggest that after an early immune reactions supported by a TH2-like cytokine secrection, there is a switching in the cytokine pattern to a TH1-like cytokine pattern

Facial granuloma [IL GRANULOMA FACIALE]

Granuloma faciale is classified as a leukocytoclastic vasculitis. It typically occurs on the face as a reddish, elevated, well circumscribed, usually solitary nodule. Occasionally multiple lesions appear. The lesions are histologically characterized by a dense dermal inflammatory infiltrate separated from epidermis by a 'grenz zone' of uninvolved dermis. A case of a 50-year old man with a 3 cm nodular lesion on the chin and a papular lesion on the cheek is reported. In three years the lesions showed a very slow enlargement. No other diseases were associated. The histology was typical for granuloma faciale; an immunohistochemical study showed the presence of CD4 + CD45RO + cells with no CD4+CD45RA+ cells. This patient underwent an excision of the lesions, but after two years there was a recurrence of the lesion on the chin and two new lesions appeared on the cheek. Intralesional injection of triamcinolone (5 mg/ml) induced a regression of the lesions with no other recurrence