Structural-functional analysis in theoretical sociology : a methodological inquiry

Thesis (DPhil) (Sociology and Social Anthropology))--University of Stellenbosch, 1967

Beroespkeuses van studente

Thesis (MA (Sociology and Social Anthropology))--University of Stellenbosch, 1964

Youth in the new South Africa: towards policy formulation: main report of the Co-operative Research Programme: South African Youth

This book deals with questions like Does South Africa have a "youth crisis"? And are its youth a marginalised "lost generation"? This book is indispensable reading for all decision makers, members of youth and other organisations, educationists, employees and others dealing with youth issues

Next generation sequencing improves detection of drug resistance mutations in infants after PMTCT failure.

BackgroundNext generation sequencing (NGS) allows the detection of minor variant HIV drug resistance mutations (DRMs). However data from new NGS platforms after Prevention-of-Mother-to-Child-Transmission (PMTCT) regimen failure are limited.ObjectiveTo compare major and minor variant HIV DRMs with Illumina MiSeq and Life Technologies Ion Personal Genome Machine (PGM) in infants infected despite a PMTCT regimen.Study designWe conducted a cross-sectional study of NGS for detecting DRMs in infants infected despite a zidovudine (AZT) and Nevirapine (NVP) regimen, before initiation of combination antiretroviral therapy. Sequencing was performed on PCR products from plasma samples on PGM and MiSeq platforms. Bioinformatic analyses were undertaken using a codon-aware version of the Smith-Waterman mapping algorithm and a mixture multinomial error filtering statistical model.ResultsOf 15 infants, tested at a median age of 3.4 months after birth, 2 (13%) had non-nucleoside reverse transcriptase inhibitor (NNRTI) DRMs (K103N and Y181C) by bulk sequencing, whereas PGM detected 4 (26%) and MiSeq 5 (30%). NGS enabled the detection of additional minor variant DRMs in the infant with K103N. Coverage and instrument quality scores were higher with MiSeq, increasing the confidence of minor variant calls.ConclusionsNGS followed by bioinformatic analyses detected multiple minor variant DRMs in HIV-1 RT among infants where PMTCT failed. The high coverage of MiSeq and high read quality improved the confidence of identified DRMs and may make this platform ideal for minor variant detection

The question is not whether to promote or not to promote, but rather when to promote

The Klein Karoo National Arts Festival (KKNK) is one of South Africa's largest and most popular arts festivals. The success of the festival is dependent on the number of tickets sold. Therefore, in order to ensure an increase in ticket sales, the festival organisers/marketers need to know how long before the event visitors decide to attend the festival so that they can plan their promotional strategy and know how long before the festival the event should be promoted. The purpose of this research is to segment visitors to the KKNK based on their decision-making style and, more specifically, their planning time. To achieve this goal, a questionnaire survey was conducted at the festival in 2011 (2–9 April), where 479 questionnaires were administered. A distinction was made between different market segments based on their decision-making time. Two segments were identified namely Extended and routine decision-makers and Spontaneous decision-makers. Two-way frequency tables and Chi-square tests as well as ANOVAs and Tukey's multiple comparisons identified the differences between the segments based on socio-demographics, behavioural characteristics and overall satisfaction as well as travel motivation. The results showed significant differences between the two decision-making segments and indicated that marketing should be done within specific time frames in order to attract both visitor groups. This research thus addresses the issue of when arts festivals such as the KKNK should promote themselves and what should be included in the marketing messages.NRF, South Afric