Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase

Физико-химические и технологические характеристики зюзника европейского травы экстракта сухого и композиции на его основе

Today, mainly synthetic drugs are used for the prevention and treatment of thyroid diseases. Along with this, the development of drugs based on dry extracts of medicinal plants of special interest. The article reports on the physicochemical and technological properties of a dry extract from Lycopus europaeus L. herbs as well as on the selection of auxiliary substances and the study of technological characteristics of the experimental samples containing this dry extract. For the drug preparation in capsules, a method of stepwise mixing of medicinal and auxiliary substances is proposed. The results of research showed that the optimum technological characteristics are offered by a composition including lactose monohydrate, Aerosil А380, and magnesium stearate of plant origin as auxiliary substances.Освящены вопросы изучения физико-химических и технологических свойств зюзника европейского травы экстракта сухого, а также выбор вспомогательных веществ и изучения технологических характеристик экспериментальных образцов, содержащих зюзника европейского травы экстракт сухой. Для получения капсул предложен метод постадийного смешивания лекарственных и вспомогательных веществ. Результаты исследований показали, что оптимальными технологическими характеристиками обладает состав, в котором в качестве вспомогательных веществ используются лактоза моногидрат, аэросил А 380 и магния стеарат растительный

Physicochemical and Technological Characteristics of Lycopus Europaeus L. Dry Herbal Extract and Related Compositions

The physicochemical and technological properties of Lycopus europaeus dry herbal extract were studied. Excipients were also selected. The technological characteristics of experimental samples containing L. europaeus dry herbal extract were studied. Stepwise mixing of drugs and excipients was proposed to prepare capsules. The results showed that a formulation in which lactose monohydrate, AEROSIL® A380, and vegetable magnesium stearate were used as excipients had the optimal technological characteristics. © 2019, Springer Science+Business Media, LLC, part of Springer Nature

Results analysis of agricultural organizations subsidy

The article presents some issues of the methodology of the study of state support for agricultural production in the aspect of efficiency. The dynamic series of profitability for certain types of products sold by agricultural organizations with and without budget subsidies are used as source data. First, a preliminary analysis and pairwise comparison of the series using nonparametric methods is carried out. Further, in order to use complete information on all the data, the methods of reduction to three variables are applied. In order to compare different methods, the principal component method and autoencoding using a neural network were used. The transformed data was also compared with and without subsidies. Conclusions and practical recommendations on the results obtained, as well as directions for the development of scientific research, are formulated

APPLICATION OF ANALYSIS OF FUR'E IS IN DIGICOM

У статті розглянуто використання методів Фур’є для аналізу лінійних систем. Приділено увагу ідеальній періодичній послідовності прямокутних імпульсів.В статье рассмотрено использование методов Фурье для анализа линейных систем. Уделено внимание идеальной периодической последовательности прямоугольных импульсов.In the article the use of methods is considered Fur'e for the analysis of the linear systems. Attention ideal periodic string of rectangular pulses is spared

Dry Reforming of Methane over GdFeO3-Based Catalysts

Abstract: Features of dry reforming of methane over perovskite-type complex oxide GdFeO3 synthesized by several methods (solid-phase, citrate–nitrate sol–gel, glycine–nitrate sol–gel syntheses) have been studied. It has been found that the use of the sol–gel method leads to the formation of porous catalysts consisting of nanosized particles. Significant differences in morphology and texture affect the catalytic properties of GdFeO3. The sample synthesized by the citrate–nitrate sol–gel method mediates the conversion of hydrogen contained the feed methane to molecular hydrogen at a selectivity of 90%. It has been shown that GdFeO3-based catalysts exhibit a stable on-stream behavior for a long time. © 2020, Pleiades Publishing, Ltd