41 research outputs found

    Deep Inelastic Structure Functions in a Covariant Spectator Model

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    Deep-inelastic structure functions are studied within a covariant scalar diquark spectator model of the nucleon. Treating the target as a two-body bound state of a quark and a scalar diquark, the Bethe-Salpeter equation (BSE) for the bound state vertex function is solved in the ladder approximation. The valence quark distribution is discussed in terms of the solutions of the BSE.Comment: 22 pages, LaTeX, 7 Postscript figures included using epsfig.st

    PARP-1 Val762Ala Polymorphism Is Associated with Risk of Cervical Carcinoma

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    PARP-1 is a nuclear enzyme that plays an important role in DNA repair, recombination, proliferation and the genome stability. The PARP-1 Val762Ala polymorphism has been associated with increased risk of developing cancers of the prostate, esophagus and lung. The aim of this study was to determine whether the PARP-1 Val762Ala polymorphism is associated with the risk of cervical carcinoma. MA-PCR was used to genotype the PARP-1 Val762Ala polymorphism in 539 women with cervical carcinoma, 480 women with CIN and 800 controls. The genotyping method was confirmed by the DNA sequencing analysis. The PARP-1 Val762Ala polymorphism was not associated with the risk of CIN. However, women carrying the PARP-1 Ala762Ala genotype were significantly susceptible to cervical carcinoma (OR: 2.70, 95% CI: 1.47–3.70), and the similar results were also found in squamous cell carcinoma (OR: 2.56, 95% CI: 1.47–3.70). In HPV positive population, the PARP-1 Ala762Ala genotype was also associated with increased risk of cervical carcinoma (OR: 5.56, 95% CI: 2.08–14.3). Our results indicate that the PARP-1 Ala762Ala genotype increases the risk of cervical carcinoma
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