1,822 research outputs found

    Quantitative Analysis of Economic Complexity and Industrial Competitiveness of Asian Countries

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    This paper mainly quantifies the economic development situation and industrial competitiveness of Asian countries by measuring the Generalized Economic Complexity Index (GECI) and statistical indicators. The measurement results reveal that it can reflect the real and effective national economic industrial competitiveness more accurately than traditional macro-economic indicators promptly. Another new finding is the GECI of economies, which shows clear geographical differences, with relatively the highest in the East Asia. Besides, we compare the potential of industrial upgrading and conclude that China, Turkey and India have stronger industrial upgrading, while Qatar and Kuwait are obviously weaker

    A novel role for 14-3-3σ in regulating epithelial cell polarity

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    The loss of epithelial polarity is thought to play an important role during mammary tumor progression. Using a unique transgenic mouse model of ErbB2-induced mammary tumorigenesis, we demonstrated previously that amplification of ErbB2 is frequently accompanied by loss of the 14-3-3σ gene. Here, we demonstrate that ectopic expression of 14-3-3σ results in restoration of epithelial polarity in ErbB2-transformed mammary tumor cells. We further demonstrate that targeted deletion of 14-3-3σ within primary mammary epithelial cells increases their proliferative capacity and adversely affects their ability to form polarized structures. Finally, we show that 14-3-3σ can specifically form complexes with Par3, a protein that is essential for the maintenance of a polarized epithelial state. Taken together, these observations suggest that 14-3-3σ plays a critical role in retaining epithelial polarity. © 2010 by Cold Spring Harbor Laboratory Press

    Evaluation and attribution of historical surface air temperature changes over China simulated by coupled and uncoupled models

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    The increase in the average surface air temperature anomaly (SATA) over China is higher than the global average. However, the accurate simulation and attribution of regional SATA evolution remain challenging for current global climate models. This study simulates historical SATA variations over China using the coupled (FGOALS-g3) and uncoupled (atmospheric component, GAMIL3) models and examines their possible causes. Results show that both models reproduce the historical SATA variation with higher correlation coefficients (0.735 and 0.782) than many global climate models (0.25–0.56), although they overestimate or underestimate the changes of SATA to some extent in different periods. The results show that the cooling trend during 1941–1970 is well simulated with the coupled model while poorly presented with the uncoupled model; the coupled simulations particularly produce stronger long-term trends than the uncoupled ones during 1870–2014 considering full interaction among the atmosphere, ocean, and sea ice. In contrast, the uncoupled simulations reproduce better decadal and multi-decadal SATA variations owing to the constraints of the observed sea surface temperature (SST), such as the Atlantic multidecadal oscillation, and sea ice cover. Using Detection and Attribution Model Intercomparison Project (DAMIP) experiments, we found that the warming in the early 20th century and the recent 50 years is mainly driven by natural forcings and greenhouse gases (GHGs), whereas the cooling during 1941–1970 is caused by natural factors and anthropogenic aerosols. The cooling effects of anthropogenic aerosols are mainly attributed from the indirect SST-mediated responses through the atmosphere-ocean interactions in the coupled model
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