Therapie und Prophylaxe von entzuendlichen Lebererkrankungen durch das HBV und HCV Schlussbericht

To study the immunopathogenesis of chronic HBV and HCV infections liver-infiltrating and peripheral blood T cells were isolated and phenotyped resulting in an enrichment of CD8+CTL and CD4+T helper cells at the inflammations site. In chronic HBV carriers HBcAg specific T helper cells secreted large amounts of interferon-gamma and might induce the HBcAg specific CTL that could lyse HBV infected target cells. In chronic HCV carriers the existence of core specific Th1 helper cells corelated with the inflammatory activity and the non-response to the interferon-alpha therapy. In addition, preliminary data demonstrated CD8+HCV-specific CTL during acute exacerbations. The anti-HCV antibody response correlated also with the inflammatory activity and the non-response and, in addition, with the extrahepatic replication in the peripheral blood lymphocytes. Thus, the humoral immune response might influence the immunopathogenesis of chronic hepatitis C and the extrahepatic HCV-replication might serve as reservoir during interferon treatment. (orig.)SIGLEAvailable from TIB Hannover: DtF QN1(44,4) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman

Transaction-Based Pseudonyms in Audit Data for Privacy Respecting Intrusion Detection

Abstract. Privacy and surveillance by intrusion detection are poten-tially conflicting organizational and legal requirements. In order to sup-port a balanced solution, audit data is inspected for personal data and identifiers referring to real persons are substituted by transaction-based pseudonyms. These pseudonyms are constructed as shares for a suitably adapted version of Shamir’s cryptographic approach to secret sharing. Under sufficient suspicion, expressed as a threshold on shares, audit an-alyzers can perform reidentification