Blueberry Progress Reports

The 1980 edition of the Blueberry Progress Reports was prepared for the Maine Blueberry Commission and the University of Maine Blueberry Advisory Committee by researchers with the Maine Life Sciences and Agriculture Experiment Station and Maine Cooperative Extension Service at the University of Maine, Orono. Projects in this report include: 1. Weed Control in Lowbush Blueberry Fields 2. Pruning of Blueberries 3. Integrated Pest Management of Blueberries in Maine 4. Physiology and Culture of the Lowbush Blueberry 5. Blueberry Diseases: Incidence and Control 6. Insects Affecting the Blueberry 7. Effect of Plant-Water Stress on Lowbush Blueberry Growth, Yield and Quality 8. Blueberry Extension Progress Report 9. Plan of Work -1981- Blueberry Extensio

Blueberry Progress Reports

The 1981 edition of the Blueberry Progress Reports was prepared for the Maine Blueberry Commission and the University of Maine Blueberry Advisory Committee by researchers with the Maine Life Sciences and Agriculture Experiment Station and Maine Cooperative Extension Service at the University of Maine, Orono. Projects in this report include: 1. Weed Control in Lowbush Blueberry Fields 2. Pruning of Blueberries 3. 1982 Blueberry Fruit Fly Monitoring IPM Program 4. Physiology and Culture of the Lowbush Blueberry 5. Blueberry Diseases: Incidence and Control 6. Control, biology, and ecology of insects affecting lowbush blueberries 7. Blueberry Extension Progress Report 8. Plan of Work - 1982 - Blueberry Extensio

Blueberry Progress Reports

The 1982 edition of the Blueberry Progress Reports was prepared for the Maine Blueberry Commission and the University of Maine Blueberry Advisory Committee by researchers with the Maine Life Sciences and Agriculture Experiment Station and Maine Cooperative Extension Service at the University of Maine, Orono. Projects in this report include: 1. Introduction 2. Blueberry IPM Program 3. Guthion Drift Study 4. Control, Biology, and Ecology of Insects 5. Blueberry Diseases: Incidence and Control 6. Physiology and Culture of the Lowbush Blueberry 7. Weed Control in Lowbush Blueberries 8. Pruning Blueberrie

Blueberry Progress Reports

The 1983 edition of the Blueberry Progress Reports was prepared for the Maine Blueberry Commission and the University of Maine Blueberry Advisory Committee by researchers with the Maine Agricultural Experiment Station and Maine Cooperative Extension Service at the University of Maine, Orono. Projects in this report include: 1. Introduction 2. Forest Tent Caterpillar in Blueberries 3. Control, Biology, and Ecology of Insects Affecting Lowbush Blueberries 4. Blueberry Diseases: Incidence and Control 5. Physiology and Culture of the Lowbush Blueberry 6. Weed Control in Lowbush Blueberry Fields 7. Product Development of Lowbush Blueberrie

Equality Saturation: A New Approach to Optimization

Optimizations in a traditional compiler are applied sequentially, with each optimization destructively modifying the program to produce a transformed program that is then passed to the next optimization. We present a new approach for structuring the optimization phase of a compiler. In our approach, optimizations take the form of equality analyses that add equality information to a common intermediate representation. The optimizer works by repeatedly applying these analyses to infer equivalences between program fragments, thus saturating the intermediate representation with equalities. Once saturated, the intermediate representation encodes multiple optimized versions of the input program. At this point, a profitability heuristic picks the final optimized program from the various programs represented in the saturated representation. Our proposed way of structuring optimizers has a variety of benefits over previous approaches: our approach obviates the need to worry about optimization ordering, enables the use of a global optimization heuristic that selects among fully optimized programs, and can be used to perform translation validation, even on compilers other than our own. We present our approach, formalize it, and describe our choice of intermediate representation. We also present experimental results showing that our approach is practical in terms of time and space overhead, is effective at discovering intricate optimization opportunities, and is effective at performing translation validation for a realistic optimizer.Comment: 80 pages, 39 figure

Maximizing Diversity from a Kinase Screen: Identification of Novel and Selective pan-Trk Inhibitors for Chronic Pain

We have identified several series of small molecule inhibitors of TrkA with unique binding modes. The starting leads were chosen to maximize the structural and binding mode diversity derived from a high throughput screen of our internal compound collection. These leads were optimized for potency and selectivity employing a structure based drug design approach adhering to the principles of ligand efficiency to maximize binding affinity without overly relying on lipophilic interactions. This endeavor resulted in the identification of several small molecule pan-Trk inhibitor series that exhibit high selectivity for TrkA/B/C versus a diverse panel of kinases. We have also demonstrated efficacy in both inflammatory and neuropathic pain models upon oral dosing. Herein we describe the identification process, hit-to-lead progression, and binding profiles of these selective pan-Trk kinase inhibitors