Synthesis and Biological Evaluation of Some Novel Substituted N-Benzylideneaniline Derivatives

ABSTRACT N-benzylideneaniline is a class of important compounds in medicinal and pharmaceutical field. Nbenzylideneaniline represents a model aromatic Schiff base and it is also a classic bioisoster of stilbene and resveratrol. Keeping in view the biological importance of N-benzylideneaniline we have synthesized some novel Nbenzylideneaniline derivatives. The prepared compounds were tested for their in vitro antibacterial, antifungal and antioxidant activity. (4-fluoro-benzylidene)-(3,5-dichloro-phenyl)-amine (5i) showed in vitro antibacterial activity comparable to that of the standard Penicillin against Escherichia coli. The results of the in vitro antifungal activity showed that most of the synthesized derivatives have proven their antifungal potential. The results of the in vitro antioxidant tests showed that most of the synthesized compounds showed moderate (%RSA >50%) to mild (%RSA >40%) radical scavenging activity

Metal-free heterogeneous and mesoporous biogenic graphene-oxide nanoparticle-catalyzed synthesis of bioactive benzylpyrazolyl coumarin derivatives

We report the preparation of graphene oxide nanoparticles (GONPs), a metal-free, heterogeneous, non-toxic, reusable and mesoporous green-(acid)-catalyst obtained by sugar carbonization through a micro-wave chemical synthesis method for the synthesis of bio-active benzylpyrazolyl coumarin derivatives (BCDs) under thermal conditions (50 [degree]C) in ethanol solvent. The obtained products were purified by re-crystallization from ethanol, assuring usability of GONPs in multicomponent reactions (MCRs) that could find wide application in the synthesis of a variety of biologically potent molecules of therapeutic significance

Aldose reductase inhibitory activity studies of THERACURMIN

<p>THERACURMIN a commercially available nano-dispersion of curcumin used to treat after effects of alcohol has been evaluated for <i>in vitro</i> ARI activity on Aldose reductase isolated from the bovine lens. As envisaged, the product displays better ARI activity with IC₅₀ value of 3 μM. The observed ARI activity of THERACURMIN is of therapeutic significance as the limited bioavailability of curcumin limits its clinical use.</p

Biodiesel production from Argemone mexicana seed oil using crystalline manganese carbonate

This communication explores the feasibility of biodiesel production from a weed plant Argemone mexicana seed oil and an efficient catalyst crystalline manganese carbonate. To the best of the authors' knowledge, this is the first study making use of pure, crystalline, ash colored manganese carbonate as a heterogeneous catalyst for the production of methyl esters as fuel from Argemone mexicana seed oil. The optimum process conditions for the conversion of Argemone mexicana oil to its methyl ester by transesterification required 1% manganese carbonate as catalyst with alcohol to oil ratio 5:1 at 60°C to yield biodiesel of 99.99% purity. The methyl esters obtained were examined by Gas chromatography analysis