3-(2-Hydroxy­ethyl)-2-(p-tolyl­amino)­quinazolin-4(3H)-one

In the title compound, C17H17N3O2, the quinazolinone ring system is essentially planar. The benzene ring is twisted with respect to it by a dihedral angle of 32.7 (5)°. The mol­ecular conformation is stabilized by an N—H⋯O hydrogen bond, and the crystal structure is stabilized by inter­molecular O—H⋯N inter­actions

Controllable Preparation of Highly Crystalline Sulfur-Doped Π-Conjugated Polyimide Hollow Nanoshell for Enhanced Photocatalytic Performance

In this study, a series of highly crystalline π-conjugated polyimide photocatalysts with porous nano hollow shell (HSPI) was prepared for the first time by the hard template method by adjusting the addition ratio of the template precursor. SiO2 nanospheres not only serve as template agents but also as dispersants to make precursors of SPI more uniform, and the degree of polymerization will be better, resulting in significantly enhanced crystallinity of HSPI relative to bulk SPI (BSPI). More strikingly, it is found that HSPI has a larger specific surface area, stronger visible light absorption, and higher separation efficiency of photogenerated electron and hole pairs compared with BSPI by various spectral means characterization analysis. These favorable factors significantly enhanced the photocatalytic degradation of methyl orange (MO) by HSPI. This work provides a promising approach for the preparation of cheap, efficient, environmentally friendly, and sustainable photocatalysts

GTPBP4 Promotes Gastric Cancer Progression via Regulating P53 Activity

Background/Aims: gastric cancer is a serious health concern with high morbidity and mortality. Therefore, it is urgent to find novel targets for gastric cancer diagnosis and treatment. Methods: qRT-PCR and immunohistochemistry assays were used to detect GTPBP4 expression in gastric cancer tissues, and gastric cancer and gastric epithelial cells. Lentivirus infection was used to construct GTPBP4 stable knockdown cells. Annexin V/PI apoptosis, CCK8, EdU incorporation and cell clone formation analysis were performed to evaluate the effects of GTPBP4 on gastric cancer cell proliferation and apoptosis. Further RNA-based high-throughput sequencing and co-IP assays were constructed to explore the related mechanisms contributing to GTPBP4-mediated effects. Results: GTPBP4 expression was significantly increased in gastric cancer tissues compared with that in adjacent normal tissues, and positively correlated with gastric cancer stages. Meanwhile, GTPBP4 level was markedly upregulated in gastric cancer cells than in gastric epithelial cells. Additionaly, stable knockdown of GTPBP4 inhibited cell proliferation and promoted cell apoptosis. Mechanistically, p53 and its related signaling were significantly activated in GTPBP4 stable knockdown cells. And GTPBP4 interacted with p53 in gastric cancer cells. Conclusions: our results provide insights into mechanistic regulation and linkage of the GTPBP4-p53 in gastric cancer, and also a valuable potential target for gastric cancer

Phosphorescent Platinum(II) Complexes Bearing 2‑Vinylpyridine-type Ligands: Synthesis, Electrochemical and Photophysical Properties, and Tuning of Electrophosphorescent Behavior by Main-Group Moieties

A series of 2-vinylpyridine-type platinum­(II) complexes bearing different main-group blocks (B­(Mes)₂, SiPh₃, GePh₃, NPh₂, POPh₂, OPh, SPh, and SO₂Ph, where Mes = 2-morpholinoethanesulfonic acid) were successfully prepared. As indicated by the X-ray single-crystal diffraction, the concerned phosphorescent platinum­(II) complexes exhibit distinct molecular packing patterns in the solid state to bring forth different interactions between individual molecules. The photophysical characterizations showed that the emission maxima together with phosphorescent quantum yield of these complexes can also be affected by introducing distinct main-group moieties with electron-donating or electron-withdrawing characters. Furthermore, these 2-vinylpyridine-type platinum­(II) complexes exhibit markedly different photophysical and electrochemical properties compared with their 2-phenylpyridine-type analogues, such as higher-lying highest occupied molecular orbital levels and lower-energy phosphorescent emissions. Importantly, these complexes can show good potential as deep red phosphorescent emitters to bring attractive electroluminescent performances with Commission Internationale de L’Eclairage (CIE) coordinates very close to the standard red CIE coordinates of (0.67, 0.33) recommended by the National Television Standards Committee. Hence, these results successfully established structure–property relationship concerning photophysics, electrochemistry, and electroluminescence, which will not only provide important information about the optoelectronic features of these novel complexes but also give valuable clues for developing novel platinum­(II) phosphorescent complexes

Phosphorescent Platinum(II) Complexes Bearing 2‑Vinylpyridine-type Ligands: Synthesis, Electrochemical and Photophysical Properties, and Tuning of Electrophosphorescent Behavior by Main-Group Moieties

A series of 2-vinylpyridine-type platinum­(II) complexes bearing different main-group blocks (B­(Mes)₂, SiPh₃, GePh₃, NPh₂, POPh₂, OPh, SPh, and SO₂Ph, where Mes = 2-morpholinoethanesulfonic acid) were successfully prepared. As indicated by the X-ray single-crystal diffraction, the concerned phosphorescent platinum­(II) complexes exhibit distinct molecular packing patterns in the solid state to bring forth different interactions between individual molecules. The photophysical characterizations showed that the emission maxima together with phosphorescent quantum yield of these complexes can also be affected by introducing distinct main-group moieties with electron-donating or electron-withdrawing characters. Furthermore, these 2-vinylpyridine-type platinum­(II) complexes exhibit markedly different photophysical and electrochemical properties compared with their 2-phenylpyridine-type analogues, such as higher-lying highest occupied molecular orbital levels and lower-energy phosphorescent emissions. Importantly, these complexes can show good potential as deep red phosphorescent emitters to bring attractive electroluminescent performances with Commission Internationale de L’Eclairage (CIE) coordinates very close to the standard red CIE coordinates of (0.67, 0.33) recommended by the National Television Standards Committee. Hence, these results successfully established structure–property relationship concerning photophysics, electrochemistry, and electroluminescence, which will not only provide important information about the optoelectronic features of these novel complexes but also give valuable clues for developing novel platinum­(II) phosphorescent complexes