Métastases endobronchiques d’un mélanome malin d’origine rectale: cas clinique et revue de la littérature

Le mélanome anorectal est une tumeur rare représentant 1,5 % de tous les mélanomes et moins de1 % des cancers anorectaux. Son pronostic est redoutable à cause de la survenue précoce de métastases. Le poumon est un site métastatique classique du mélanome malin, les localisations endobronchiques sont toutefois rares. Des mélanomes primitifs anorectaux ont également été décrits et sont de mauvais pronostic. Nous rapportons un cas de métastases broncho-pulmonaires de mélanome malin d’origine rectal. Comme c’est souvent le cas, les possibilités thérapeutiques sont limitées.Pan African Medical Journal 2013 14: 6

Toxicity Profile of the Aqueous Ethanol Root Extract of Corrigiola telephiifolia Pourr. (Caryophyllaceae) in Rodents

Corrigiola telephiifolia Pourr. (Caryophyllaceae) is a Moroccan medicinal plant. Despite its popular usage, no study has been published concerning its toxicological profile. The acute toxicity of C. telephiifolia root extract was evaluated by giving it orally to mice at single doses of 5000, 10000, and 14000 mg/kg bodyweight. The extract was also administered at doses of 5, 70, and 2000 mg/kg bodyweight per day to rats for a forty-day toxicity study. No mortality or signs of toxicity were observed in the acute study. In the forty-day study in rats, the extract at 5 mg/kg/day showed no toxicological effects in either sex. At 70 mg/kg/day, the treated group differed from the control only by a significant decrease in serum concentrations of sodium and chloride ions (P < .05). At the dose of 2000 mg/kg/day, the extract significantly increased the serum concentrations of creatinine, alkaline phosphatase, gamma-glutamyltransferase and phosphorus (P < .05) all suggestive of functional nephrotoxicity and hepatotoxicity. The relative bodyweight of both sexes decreased at the dose of 2000 mg/kg/day, with a fast recovery for males. Histological examination did not reveal any treatment-related effects. In conclusion, Corrigiola extract appears safe at the doses used ethno-medicinally. Much higher doses pose toxicological risks

Lemon juice has protective activity in a rat urolithiasis model

<p>Abstract</p> <p>Background</p> <p>The use of herbal medicines (medicinal plants or phytotherapy) has recently gained popularity in Europe and the United States. Nevertheless the exact mechanism of the preventive effects of these products is still far to be clearly established, being its knowledge necessary to successfully apply these therapies to avoid stone formation.</p> <p>Methods</p> <p>The effect of oral lemon juice administration on calcium oxalate urolithiasis was studied in male Wistar rats. Rats were rendered nephrolithic by providing drinking water containing 0.75% ethylene glycol [v/v] (EG) and 2% ammonium chloride [w/v] (AC) for 10 days. In addition to EG/AC treatment, three groups of rats were also gavage-administered solutions containing 100%, 75% or 50% lemon juice [v/v] (6 μl solution/g body weight). Positive control rats were treated with EG/AC but not lemon juice. Negative control rats were provided with normal drinking water, and were administered normal water by gavage. Each group contained 6 rats. After 10 days, serum samples were collected for analysis, the left kidney was removed and assessed for calcium levels using flame spectroscopy, and the right kidney was sectioned for histopathological analysis using light microscopy.</p> <p>Results</p> <p>Analysis showed that the rats treated with EG/AC alone had higher amounts of calcium in the kidneys compared to negative control rats. This EG/AC-induced increase in kidney calcium levels was inhibited by the administration of lemon juice. Histology showed that rats treated with EG/AC alone had large deposits of calcium oxalate crystals in all parts of the kidney, and that such deposits were not present in rats also treated with either 100% or 75% lemon juice.</p> <p>Conclusion</p> <p>These data suggest that lemon juice has a protective activity against urolithiasis.</p

Changes in body weight in the various rat groups over the ten days of the experiment

<p><b>Copyright information:</b></p><p>Taken from "Lemon juice has protective activity in a rat urolithiasis model"</p><p>http://www.biomedcentral.com/1471-2490/7/18</p><p>BMC Urology 2007;7():18-18.</p><p>Published online 5 Oct 2007</p><p>PMCID:PMC2194764.</p><p></p