2,150 research outputs found
2-Chloro-N′-(2-chlorobenzylidene)benzohydrazide
The molecule of the title compound, C14H10Cl2N2O, adopts an E configuration about the C=N bond. The dihedral angle between the two benzene rings is 79.7 (2)°. In the crystal structure, molecules are linked by intermolecular N—H⋯O, C—H⋯Cl and C—H⋯O hydrogen bonds, forming chains running along the b axis
Amplifying Frequency Up-Converted Infrared Signals with a Molecular Optomechanical Cavity
Frequency up-conversion, enabled by molecular optomechanical coupling, has
recently emerged as a promising approach for converting infrared signals into
the visible range through quantum coherent conversion of signals. However,
detecting these converted signals poses a significant challenge due to their
inherently weak signal intensity. In this work, we propose an amplification
mechanism capable of enhancing the signal intensity by a factor of 1000 or more
in a molecular-cavity system consisting molecules. The mechanism takes
advantage of the strong coupling enhancement with molecular collective mode and
Stokes sideband pump. Our work demonstrates a feasible approach for
up-converting infrared signals to the visible range.Comment: 5 pages, 4 figures for the main text; 6 pages, 2 figures for
Supplementary Materia
Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions
Extracellular adhesion molecules and their neuronal receptors guide the growth and branching of axons and dendrites. Growth cones are attracted to intermediate targets, but they must switch their response upon arrival so that they can move away and complete the next stage of growth. Here, we show that KPC-1, a C. elegans Furin homolog, regulates the level of the branching receptor DMA-1 on dendrites by targeting it to late endosomes. In kpc-1 mutants, the level of DMA-1 is abnormally high on dendrites, resulting in trapping of dendrites at locations where a high level of the cognate ligand, the adhesion molecule SAX-7/L1, is present. The misregulation of DMA-1 also causes dendritic self-avoidance defects. Thus, precise regulation of guidance receptors creates flexibility of responses to guidance signals and is critical for neuronal morphogenesis
Effects of suppressor of cytokine signaling 3 (SOCS3) on the development of colon cancer via regulation of HIF-1α
Purpose: To investigate the influence of suppressor of cytokine signaling 3 (SOCS3) on rats with colon cancer (CC).
Methods: Sprague-Dawley (SD) rats were randomly divided into CC group and control group. CC models were constructed. The expression of SOCS3 in CC tissues was determined by quantitative real time-polymerase chain reaction (qRT-PCR). Hematoxylin-eosin staining (H&E) was used to examine colon tissue morphology, while immunohistochemistry (IHC) staining assay was performed to determine the expression of SOCS3 protein in colon tissues. The content of HIF-1α, phosphorylated phosphatidylinositol 3-hydroxy kinase (p-PI3K), and phosphorylated protein kinase B (p-AKT) proteins was determined by Western blotting (WB).
Results: Compared with that in the control group, the number of tumors in the CC group was significantly increased (p < 0.05). Protein and messenger ribonucleic acid (mRNA) expressions of SOCS3 were down-regulated in CC group (p < 0.05), while protein expressions of p-PI3K, p-AKT and HIF-1α were significantly elevated in CC group (p < 0.05).
Conclusion: SOCS3 is poorly expressed in CC rats, and promotes the expression of HIF-1α by activating PI3K/AKT signaling pathway. The findings, thus, provide a probable strategy for management of colon cancer
Effects of SOCS3 on the development of colon cancer via regulation of HIF-1α
Purpose: To investigate the influence of suppressor of cytokine signaling 3 (SOCS3) on rats with colon cancer (CC).
Methods: Sprague-Dawley (SD) rats were randomly divided into CC group and control group, and then CC rat model was constructed. The expression of SOCS3 in CC tissues was determined by quantitative real time-polymerase chain reaction (qRT-PCR). Hematoxylin-eosin staining (H&E) was used to examine colon tissue morphology. Immunohistochemistry (IHC) staining assay was performed to determine the expression of SOCS3 protein in colon tissues. The contents of HIF-1α, phosphorylated phosphatidylinositol 3-hydroxy kinase (p-PI3K), and phosphorylated protein kinase B (p-AKT) proteins were determined by Western blotting (WB).
Results: Compared with that in the control group, the number of tumors in CC group was significantly increased (p < 0.05). 2). On the other hand, protein and message ribonucleic acid (mRNA) expressions of SOCS3 were down-regulated in CC group (p < 0.05). 3), while protein expressions of p-PI3K, p-AKT and HIF-1α were raised in CC group (p < 0.05).
Conclusion: SOCS3 is lowly expressed in CC rats, and promotes the expression of HIF-1α by activating PI3K/AKT signaling pathway. Thus, SOCS3 provides a therapeutic strategy for the management of colon cancer.
Keywords: Colon cancer; Suppressor of cytokine signaling protein 3 (SOCS3); Hypoxia inducible factor-1
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Precise regulation of the guidance receptor DMA-1 by KPC-1/furin instructs dendritic branching decisions
Extracellular adhesion molecules and their neuronal receptors guide the growth and branching of axons and dendrites. Growth cones are attracted to intermediate targets, but they must switch their response upon arrival so that they can move away and complete the next stage of growth. Here, we show that KPC-1, a C. elegans Furin homolog, regulates the level of the branching receptor DMA-1 on dendrites by targeting it to late endosomes. In kpc-1 mutants, the level of DMA-1 is abnormally high on dendrites, resulting in trapping of dendrites at locations where a high level of the cognate ligand, the adhesion molecule SAX-7/L1, is present. The misregulation of DMA-1 also causes dendritic self-avoidance defects. Thus, precise regulation of guidance receptors creates flexibility of responses to guidance signals and is critical for neuronal morphogenesis
3-(7-Methoxy-β-carbolin-1-yl)propionic acid monohydrate
In the title compound, C15H14N2O3·H2O [systematic name: 3-(7-methoxy-9H-pyrido[3,4-b]indol-1-yl)propanoic acid monohydrate], the fused rings make dhedral angles of 0.4 (1), 1.1 (2) and 1.4 (2)°. In the crystal, the water molecule is involved in the formation of three independent hydrogen-bonded chains via O—H⋯O and N—H⋯O hydrogen bonds, while the carboxy group forms an intermolecular O—H⋯N hydrogen bond
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