Analysis on U.S. Sealift Innovation Pioneer: Chester Nimitz

Sealift is not only the essential maritime tactics and techniques for modern navy, but also an important indicator to measure the naval combat capability. In the transformation of modern maritime refueling technology, Nimitz played a greatly important role. Nimitz was more than a famous militarist and strategists. In fact, he was a pioneer in promoting the innovation of marine fuel supply with excellent command capacity and mastery of technology. In 1917, Nimitz originated the riding-abeam fueling method suitable for small warships. During the early period of World War II, he reformed and developed broadside fueling suitable for aircraft carriers and other large warships, which were a leap development with historical significance. The technology of broadside fueling has successfully withstood the test of actual combat in World War II, and proved to be the important guarantee for the United States to win the Pacific war

Causality-based Cross-Modal Representation Learning for Vision-and-Language Navigation

Vision-and-Language Navigation (VLN) has gained significant research interest in recent years due to its potential applications in real-world scenarios. However, existing VLN methods struggle with the issue of spurious associations, resulting in poor generalization with a significant performance gap between seen and unseen environments. In this paper, we tackle this challenge by proposing a unified framework CausalVLN based on the causal learning paradigm to train a robust navigator capable of learning unbiased feature representations. Specifically, we establish reasonable assumptions about confounders for vision and language in VLN using the structured causal model (SCM). Building upon this, we propose an iterative backdoor-based representation learning (IBRL) method that allows for the adaptive and effective intervention on confounders. Furthermore, we introduce the visual and linguistic backdoor causal encoders to enable unbiased feature expression for multi-modalities during training and validation, enhancing the agent's capability to generalize across different environments. Experiments on three VLN datasets (R2R, RxR, and REVERIE) showcase the superiority of our proposed method over previous state-of-the-art approaches. Moreover, detailed visualization analysis demonstrates the effectiveness of CausalVLN in significantly narrowing down the performance gap between seen and unseen environments, underscoring its strong generalization capability.Comment: 16 page

Unbiased Directed Object Attention Graph for Object Navigation

Object navigation tasks require agents to locate specific objects in unknown environments based on visual information. Previously, graph convolutions were used to implicitly explore the relationships between objects. However, due to differences in visibility among objects, it is easy to generate biases in object attention. Thus, in this paper, we propose a directed object attention (DOA) graph to guide the agent in explicitly learning the attention relationships between objects, thereby reducing the object attention bias. In particular, we use the DOA graph to perform unbiased adaptive object attention (UAOA) on the object features and unbiased adaptive image attention (UAIA) on the raw images, respectively. To distinguish features in different branches, a concise adaptive branch energy distribution (ABED) method is proposed. We assess our methods on the AI2-Thor dataset. Compared with the state-of-the-art (SOTA) method, our method reports 7.4%, 8.1% and 17.6% increase in success rate (SR), success weighted by path length (SPL) and success weighted by action efficiency (SAE), respectively.Comment: 13 pages, ready to ACM Mutimedia, under revie

Security Analysis of Efficient Anonymous Authentication With Conditional Privacy Preserving Scheme for Vehicular Ad Hoc Networks

Protecting a driver’s privacy is one of the major concerns in vehicular ad hoc networks (VANETs). Currently, Azees et al. has proposed an efficient anonymous authentication protocol (EAAP) for VANETs. The authors claim that their scheme can implement conditional privacy, and that it can provide resistance against impersonation attack and bogus message attack from an external attacker. In this paper, we show that their scheme fails to resist these two types of attack as well as forgery attack. By these attacks, an attacker can broadcast any messages successfully. Further, the attacker cannot be traced by a trusted authority, which means their scheme does not satisfy the requirement of conditional privacy. The results of this article clearly show that the scheme of Azees et al. is insecure

PASTS: Progress-Aware Spatio-Temporal Transformer Speaker For Vision-and-Language Navigation

Vision-and-language navigation (VLN) is a crucial but challenging cross-modal navigation task. One powerful technique to enhance the generalization performance in VLN is the use of an independent speaker model to provide pseudo instructions for data augmentation. However, current speaker models based on Long-Short Term Memory (LSTM) lack the ability to attend to features relevant at different locations and time steps. To address this, we propose a novel progress-aware spatio-temporal transformer speaker (PASTS) model that uses the transformer as the core of the network. PASTS uses a spatio-temporal encoder to fuse panoramic representations and encode intermediate connections through steps. Besides, to avoid the misalignment problem that could result in incorrect supervision, a speaker progress monitor (SPM) is proposed to enable the model to estimate the progress of instruction generation and facilitate more fine-grained caption results. Additionally, a multifeature dropout (MFD) strategy is introduced to alleviate overfitting. The proposed PASTS is flexible to be combined with existing VLN models. The experimental results demonstrate that PASTS outperforms all existing speaker models and successfully improves the performance of previous VLN models, achieving state-of-the-art performance on the standard Room-to-Room (R2R) dataset.Comment: 15 pages, 11 figure

Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets

Most known probes for activity-based protein profiling (ABPP) use electrophilic groups that tag a single type of nucleophilic amino acid to identify cases in which its hyper-reactivity underpins function. Much important biochemistry derives from electrophilic enzyme cofactors, transient intermediates, and labile regulatory modifications, but ABPP probes for such species are underdeveloped. Here, we describe a versatile class of probes for this less charted hemisphere of the proteome. The use of an electron-rich hydrazine as the common chemical modifier enables covalent targeting of multiple, pharmacologically important classes of enzymes bearing diverse organic and inorganic cofactors. Probe attachment occurs by both polar and radicaloid mechanisms, can be blocked by molecules that occupy the active sites, and depends on the proper poise of the active site for turnover. These traits will enable the probes to be used to identify specific inhibitors of individual members of these multiple enzyme classes, making them uniquely versatile among known ABPP probes

Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes [preprint]

Known chemoproteomic probes generally use warheads that tag a single type of amino acid or modified form thereof to identify cases in which its hyper-reactivity underpins function. Much important biochemistry derives from electron-poor enzyme cofactors, transient intermediates and chemically-labile regulatory modifications, but probes for such species are underdeveloped. Here, we have innovated a versatile class of chemoproteomic probes for this less charted hemisphere of the proteome by using hydrazine as the common chemical warhead. Its electron-rich nature allows it to react by both polar and radicaloid mechanisms and to target multiple, pharmacologically important functional classes of enzymes bearing diverse organic and inorganic cofactors. Probe attachment can be blocked by active-site-directed inhibitors, and elaboration of the warhead supports connection of a target to a lead compound. The capacity of substituted hydrazines to profile, discover and inhibit diverse cofactor-dependent enzymes enables cell and tissue imaging and makes this platform useful for enzyme and drug discovery

Identification and characterization of the Remorin gene family in Saccharum and the involvement of ScREM1.5e-1/-2 in SCMV infection on sugarcane

IntroductionRemorins (REMs) are plant-specific membrane-associated proteins that play important roles in plant–pathogen interactions and environmental adaptations. Group I REMs are extensively involved in virus infection. However, little is known about the REM gene family in sugarcane (Saccharum spp. hyrid), the most important sugar and energy crop around world.MethodsComparative genomics were employed to analyze the REM gene family in Saccharum spontaneum. Transcriptomics or RT-qPCR were used to analyze their expression files in different development stages or tissues under different treatments. Yeast two hybrid, bimolecular fluorescence complementation and co-immunoprecipitation assays were applied to investigate the protein interaction.ResultsIn this study, 65 REMs were identified from Saccharum spontaneum genome and classified into six groups based on phylogenetic tree analysis. These REMs contain multiple cis-elements associated with growth, development, hormone and stress response. Expression profiling revealed that among different SsREMs with variable expression levels in different developmental stages or different tissues. A pair of alleles, ScREM1.5e-1/-2, were isolated from the sugarcane cultivar ROC22. ScREM1.5e-1/-2 were highly expressed in leaves, with the former expressed at significantly higher levels than the latter. Their expression was induced by treatment with H2O2, ABA, ethylene, brassinosteroid, SA or MeJA, and varied upon Sugarcane mosaic virus (SCMV) infection. ScREM1.5e-1 was localized to the plasma membrane (PM), while ScREM1.5e-2 was localized to the cytoplasm or nucleus. ScREM1.5e-1/-2 can self-interact and interact with each other, and interact with VPgs from SCMV, Sorghum mosaic virus, or Sugarcane streak mosaic virus. The interactions with VPgs relocated ScREM1.5e-1 from the PM to the cytoplasm.DiscussionThese results reveal the origin, distribution and evolution of the REM gene family in sugarcane and may shed light on engineering sugarcane resistance against sugarcane mosaic pathogens

Tirofiban for Stroke without Large or Medium-Sized Vessel Occlusion

The effects of the glycoprotein IIb/IIIa receptor inhibitor tirofiban in patients with acute ischemic stroke but who have no evidence of complete occlusion of large or medium-sized vessels have not been extensively studied. In a multicenter trial in China, we enrolled patients with ischemic stroke without occlusion of large or medium-sized vessels and with a National Institutes of Health Stroke Scale score of 5 or more and at least one moderately to severely weak limb. Eligible patients had any of four clinical presentations: ineligible for thrombolysis or thrombectomy and within 24 hours after the patient was last known to be well; progression of stroke symptoms 24 to 96 hours after onset; early neurologic deterioration after thrombolysis; or thrombolysis with no improvement at 4 to 24 hours. Patients were assigned to receive intravenous tirofiban (plus oral placebo) or oral aspirin (100 mg per day, plus intravenous placebo) for 2 days; all patients then received oral aspirin until day 90. The primary efficacy end point was an excellent outcome, defined as a score of 0 or 1 on the modified Rankin scale (range, 0 [no symptoms] to 6 [death]) at 90 days. Secondary end points included functional independence at 90 days and a quality-of-life score. The primary safety end points were death and symptomatic intracranial hemorrhage. A total of 606 patients were assigned to the tirofiban group and 571 to the aspirin group. Most patients had small infarctions that were presumed to be atherosclerotic. The percentage of patients with a score of 0 or 1 on the modified Rankin scale at 90 days was 29.1% with tirofiban and 22.2% with aspirin (adjusted risk ratio, 1.26; 95% confidence interval, 1.04 to 1.53, P = 0.02). Results for secondary end points were generally not consistent with the results of the primary analysis. Mortality was similar in the two groups. The incidence of symptomatic intracranial hemorrhage was 1.0% in the tirofiban group and 0% in the aspirin group. In this trial involving heterogeneous groups of patients with stroke of recent onset or progression of stroke symptoms and nonoccluded large and medium-sized cerebral vessels, intravenous tirofiban was associated with a greater likelihood of an excellent outcome than low-dose aspirin. Incidences of intracranial hemorrhages were low but slightly higher with tirofiban

Methylprednisolone as Adjunct to Endovascular Thrombectomy for Large-Vessel Occlusion Stroke

Importance It is uncertain whether intravenous methylprednisolone improves outcomes for patients with acute ischemic stroke due to large-vessel occlusion (LVO) undergoing endovascular thrombectomy. Objective To assess the efficacy and adverse events of adjunctive intravenous low-dose methylprednisolone to endovascular thrombectomy for acute ischemic stroke secondary to LVO. Design, Setting, and Participants This investigator-initiated, randomized, double-blind, placebo-controlled trial was implemented at 82 hospitals in China, enrolling 1680 patients with stroke and proximal intracranial LVO presenting within 24 hours of time last known to be well. Recruitment took place between February 9, 2022, and June 30, 2023, with a final follow-up on September 30, 2023.InterventionsEligible patients were randomly assigned to intravenous methylprednisolone (n = 839) at 2 mg/kg/d or placebo (n = 841) for 3 days adjunctive to endovascular thrombectomy. Main Outcomes and Measures The primary efficacy outcome was disability level at 90 days as measured by the overall distribution of the modified Rankin Scale scores (range, 0 [no symptoms] to 6 [death]). The primary safety outcomes included mortality at 90 days and the incidence of symptomatic intracranial hemorrhage within 48 hours. Results Among 1680 patients randomized (median age, 69 years; 727 female [43.3%]), 1673 (99.6%) completed the trial. The median 90-day modified Rankin Scale score was 3 (IQR, 1-5) in the methylprednisolone group vs 3 (IQR, 1-6) in the placebo group (adjusted generalized odds ratio for a lower level of disability, 1.10 [95% CI, 0.96-1.25]; P = .17). In the methylprednisolone group, there was a lower mortality rate (23.2% vs 28.5%; adjusted risk ratio, 0.84 [95% CI, 0.71-0.98]; P = .03) and a lower rate of symptomatic intracranial hemorrhage (8.6% vs 11.7%; adjusted risk ratio, 0.74 [95% CI, 0.55-0.99]; P = .04) compared with placebo. Conclusions and Relevance Among patients with acute ischemic stroke due to LVO undergoing endovascular thrombectomy, adjunctive methylprednisolone added to endovascular thrombectomy did not significantly improve the degree of overall disability.Trial RegistrationChiCTR.org.cn Identifier: ChiCTR210005172