CMB Spectral Distortion Constraints on Thermal Inflation

Thermal inflation is a second epoch of exponential expansion at typical energy scales $V^{1/4} \sim 10^{6 \sim 8} \mathrm{GeV}$. If the usual primordial inflation is followed by thermal inflation, the primordial power spectrum is only modestly redshifted on large scales, but strongly suppressed on scales smaller than the horizon size at the beginning of thermal inflation, $k > k_{\rm b} = a_{\rm b} H_{\rm b}$. We calculate the spectral distortion of the cosmic microwave background generated by the dissipation of acoustic waves in this context. For $k_{\rm b} \ll 10^3 \mathrm{Mpc}^{-1}$, thermal inflation results in a large suppression of the $\mu$-distortion amplitude, predicting that it falls well below the standard value of $\mu \simeq 2\times 10^{-8}$. Thus, future spectral distortion experiments, similar to PIXIE, can place new limits on the thermal inflation scenario, constraining $k_{\rm b} \gtrsim 10^3 \mathrm{Mpc}^{-1}$ if $\mu \simeq 2\times 10^{-8}$ were found.Comment: 18 pages, 7 figure

The perception of materials through oral sensation

This paper presents the results of a multimodal study of oral perception conducted with a set of material samples made from metals, polymers and woods, in which both the somatosensory and taste factors were examined. A multidimensional scaling analysis coupled with subjective attribute ratings was performed to assess these factors both qualitatively and quantitatively. The perceptual somatosensory factors of warmth, hardness and roughness dominated over the basic taste factors, and roughness was observed to be a less significant sensation compared to touch-only experiments. The perceptual somatosensory ratings were compared directly with physical property data in order to assess the correlation between the perceived properties and measured physical properties. In each case, a strong correlation was observed, suggesting that physical properties may be useful in industrial design for predicting oral perception

Dissociable circuits for visual shape learning in the young and aging human brain.

Recognizing objects in cluttered scenes is vital for successful interactions in our complex environments. Learning is known to play a key role in facilitating performance in a wide range of perceptual skills not only in young but also older adults. However, the neural mechanisms that support our ability to improve visual form recognition with training in older age remain largely unknown. Here, we combine behavioral and fMRI measurements to identify the brain circuits involved in the learning of global visual forms in the aging human brain. Our findings demonstrate the learning enhances perceptual sensitivity in the discrimination of visual forms similarly in both young and older adults. However, using fMRI we show that the neural circuits involved in visual form learning differ with age. Our results show that in young adults visual shape learning engages a network of occipitotemporal, parietal, and frontal regions that is known to be involved in perceptual decisions. In contrast, in older adults visual shape learning engages primarily parietal regions, suggesting a stronger role of attentionally-guided learning in older age. Interestingly, learning-dependent changes are maintained in higher occipitotemporal and posterior parietal regions, but not in frontal circuits, when observers perform a control task rather than engaging in a visual form discrimination task. Thus, learning may modulate read-out signals in posterior regions related to global form representations independent of the task, whereas task-dependent frontal activations may reflect changes in sensitivity with training in the context of perceptual decision making

Nitrogen Oxide Concentrations in Natural Waters on Early Earth

A key challenge in origins-of-life studies is estimating the abundances of species relevant to the chemical pathways proposed to have contributed to the emergence of life on early Earth. Dissolved nitrogen oxide anions (NO$_{X}^{-}$), in particular nitrate (NO$_{3}^{-}$) and nitrite (NO$_{2}^{-}$), have been invoked in diverse origins-of-life chemistry, from the oligomerization of RNA to the emergence of protometabolism. Recent work has calculated the supply of NO$_{X}^{-}$ from the prebiotic atmosphere to the ocean, and reported steady-state [NO$_{X}^{-}$] to be high across all plausible parameter space. These findings rest on the assumption that NO$_{X}^{-}$ is stable in natural waters unless processed at a hydrothermal vent. Here, we show that NO$_{X}^{-}$ is unstable in the reducing environment of early Earth. Sinks due to UV photolysis and reactions with reduced iron (Fe$^{2+}$) suppress [NO$_{X}^{-}$] by several orders of magnitude relative to past predictions. For pH$=6.5-8$ and $T=0-50^\circ$C, we find that it is most probable that NO$_{X}^{-}$]$<1~\mu$M in the prebiotic ocean. On the other hand, prebiotic ponds with favorable drainage characteristics may have sustained [NO$_{X}^{-}$]$\geq 1~\mu$M. As on modern Earth, most NO$_{X}^{-}$ on prebiotic Earth should have been present as NO$_{3}^{-}$, due to its much greater stability. These findings inform the kind of prebiotic chemistries that would have been possible on early Earth. We discuss the implications for proposed prebiotic chemistries, and highlight the need for further studies of NO$_{X}^{-}$ kinetics to reduce the considerable uncertainties in predicting [NO$_{X}^{-}$] on early Earth.Comment: In review for publication at Geochemistry, Geophysics, and Geosystems (G-cubed). Comments, questions, and criticism solicited; please contact corresponding author at [email protected]. SI at: https://web-cert.mit.edu/sukrit/Public/nox_si.pdf. GitHub at: https://github.com/sukritranjan/no

Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium.

K(2P) channels mediate potassium background currents essential to central nervous system function, controlling excitability by stabilizing membrane potential below firing threshold and expediting repolarization. Here, we show that alternative translation initiation (ATI) regulates function of K(2P)2.1 (TREK-1) via an unexpected strategy. Full-length K(2P)2.1 and an isoform lacking the first 56 residues of the intracellular N terminus (K(2P)2.1Delta1-56) are produced differentially in a regional and developmental manner in the rat central nervous system, the latter passing sodium under physiological conditions leading to membrane depolarization. Control of ion selectivity via ATI is proposed to be a natural, epigenetic mechanism for spatial and temporal regulation of neuronal excitability

The Dogrib Birchbark Canoe Project

The Dogrib are one of the Athapaskan, or Dene groups occupying the Mackenzie Valley area in the Northwest Territories (see map). Their hunting canoes, though engineered for traversing a rugged landscape, had elegant and flowing lines. ... Although there is a reasonably good collection of archival photographs of Dogrib canoes, mostly due to the efforts of the anthropologist J. Alden Mason ..., the historical record has preserved little knowledge pertinent to canoe construction and use, and only a small number of canoes have survived in museum collections. During our recent archaeological research on two important Dogrib canoe routes, however, we recorded the remains of nearly 30 hunting canoes .... Today, in the Dogrib communities of Snare Lake, Rae Lakes, Wha Ti and Rae-Edzo, the oral tradition is full of canoeing and canoe-related stories and remembrances, although very few surviving elders actually built one in their youth. This fact, and the large number of canoes recorded in our research, gave us a new appreciation of the importance and role they had played in travel, and led to an exciting cultural revival project: to build and document a Dogrib birchbark canoe. ... [This article briefly describes the canoe project, sharing some of what the elders taught us about Dogrib hunting canoes.