About concept and linguocultureme in the anthropocentric paradigm

It is known, the anthropocentric paradigm is a set of ideas that study language not as a dry structure, but as an open system based on living dialogue and communication, analyzing other systems in their integral relationship with people, society, culture, etc .Linguistics, which is considered one of the leading directions of anthropocentric linguistics, arose in the field of linguistics, cultural studies, ethnography, psycholinguistics, and studies the interaction and influence of language with culture, ethnos, and national mentality based on the principles of the anthropocentric paradigm .The object of this field is language and culture, and the subject is language units that show cultural semantics. In this article the author analizes  the differences between concept, notion and meaning and tries to give information about linguocultureme

Synthesis, Crystal Structures of S- and N- Benzyl Derivatives Of 5-phenyl-1,3,4-oxadiazol-2-thione

Benzylation reaction is carried out 5-phenyl-1,3,4-oxadiazol-2-thione with benzyl chloride in acetone and HMPA. In the acetone was obtained exclusively S-benzyl derivative and in the case of HMPA - isomeric mixture of S- and N-benzyl derivatives were obtained, individually isolated, characterized, and their structure was proved by spectral methods. By slow evaporation of solvents at room temperature were obtained two polymorphic crystals of 5-phenyl-1,3,4-oxadiazol-2-thione from acetone 1 and ethanol 2. Crystals of 2-benzylthio-5-phenyl-1,3,4-oxadiazole 3 and 3-benzyl-5-phenyl-1,3,4-oxadiazol-2-thione 4 obtained in similar conditions have structures without the inclusion of solvent molecules

EFFECT OF BETA-BLOCKERS AND STUDY OF AGGREGATiVE ACTIVITY OF THROMBOCYTES IN PATiENTS WITH DILATED CARDIOMYOPATHY

The aim. was to study peculiarities of ischemic and idiopathic dilated cardiomyopathy and. aggregative activity of thrombocytes and. also the response to the therapy by beta-blockers (Atenolol and Bisoprolol). Material and. methods: study of aggregative activity of thrombocytes in patients with ischemic and. idiopathic dilated cardiomyopathy, study of dynamics of aggregative activity of thrombocytes in patients with ischemic and. idiopathic dilated cardiomyopathy under the influence of 3-months therapy by Atenolol and. Bisoprolol. Research of aggregative activity of thrombocytes in patients involved in the research demonstrated reliable increase of speed and. maximum amplitude of thrombocytes aggregation at addition of 0,5 normal solution of ADP and. reliabie decrease of time of reaching of maximum amplitude of aggregation. Comparison of patients with idiopathic and. ischemic dilated cardiomyopathy revealed reliable increase of all the indices of aggregative activity in patients with ischemic dilated cardiomyopathy in comparison with ones with idiopathic form in both groups of therapy. The research shows that patients with dilated cardiomyopathy have an activation of aggregative activity of thrombocytes that is more evident in patients with ischemic form. Prolonged use of Bisoprolol allows to achieve more evident antiaggregative effect of used base therapy in comparison with use of Atenolol

Alcaloїdes Des Annonacées : Alcaloїdes Des Des Feuilles et Des Écorces De l’Annona Senegalensis

The alkaloidal content of the leaves and barks of Annona senegalensis Pers collected in Republic of Guinea, was studied for the first time and compared to that of Annona muricata L. 8 alkaloids from leaves and 4 alkaloids from barks were isolated and identified. Main alkaloids are aporphinoids (aporphines, nor-aporphines, oxo-aporphines and N-oxide aporphine) and benzyltetrahydroisoquinolines

Simulation testing of traffic flow delays in bus stop zone

Traffic flows are subject to certain delays due to the maneuvering of buses entering and leaving the stop. The study of how these delays change depending on the frequency of arrival of buses to a stop and, the change of lanes on the road, the intensity of the traffic flow on the road is important in organizing traffic and planning the movement of buses along the route. The article uses simulation models built in the PTV VISSIM program to estimate the delay time of the traffic flow on 2, 3, and 4 lane roads for 4 different values of the intensity of the traffic flow and 5 different values of the bus arrival frequency at the stop. The results obtained are analyzed. The changing nature of traffic flow delays in various scenarios has been studied

Synthesis of S-(5-aryl-1,3,4-oxadiazol-2-yl) O-alkyl carbonothioate and alkyl 2-((5-aryl-1,3,4-oxadiazol-2-yl)thio) acetate, and their antimicrobial properties

The S-(5-aryl-1,3,4-oxadiazol-2-yl) O-alkyl carbonothioate (4-9) and the alkyl 2-((5-aryl-1,3,4-oxadiazol-2-yl)thio) acetate (10-15) were synthesized by interaction of 5-aryl-1,3,4-oxadiazole-2-thiones with alkyl esters of chloroformic acid and chloroacetic acid. The yields of target compounds (7-9) obtained with isobutyl chloroformate were 69-73%, compounds (4-6) with propyl chloroformate - 74-79% and compounds (10-15) with alkyl esters of chloroacetic acid - 86-92%, respectively. The structures of the synthesized compounds were confirmed by IR, UV, 1H and 13C NMR spectra. The antibacterial and antifungal activities of these compounds were investigated. The results of in vitro antimicrobial activity tests showed that S-(5-phenyl(2-chlorophenyl)-1,3,4-oxadiazol-2-yl) O-propyl carbonothioate (4-5) and S-(5-phenyl(2-chlorophenyl)-1,3,4-oxadiazol-2-yl) O-isobutyl carbonothioate (7-8) exhibited weak, but selective antibacterial activity against gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus). At the same time, no activity was shown by compounds with two chlorine atoms in the aromatic ring (13-15) and alkyl 2-((5-aryl-1,3,4-oxadiazol-2-yl) thio) acetate (10-15)