A New Uniform Law for the International Sale of Goods: Is it Compatible with American Interests?

The prospects for adoption of a law gov- erning commercial\u27 contracts for the international sale of goods should be of compelling interest to American merchants and their legal advi- sors. The text which was presented to the diplomatic conference in March was completed by the United Nations Commission on Interna- tional Trade Law (UNCITRAL) in 1978.1 Its eighty-two articles em- body the substantive revisions of a similar document that was rejected by the United States sixteen years ago\u27--the 1964 Hague Convention Relating to a Uniform Law for the International Sale of Good

Functional networks in aging and Alzheimer’s disease: Contributions and consequences

Alzheimer’s disease is characterized by two hallmark neuropathologies: A plaques and hyperphosphorylated tau protein. A tends to arise in a diffuse manner throughout cortex, whereas tau pathology accumulates in a stereotyped pattern first in medial temporal lobe and then in selectively vulnerable neocortical regions as the disease progresses. The processes facilitating the propagation of tau pathology are still unknown, but converging cellular and neuroimaging evidence suggests that tau spreads transneuronally along pathways of functional connectivity throughout the brain. In this work, we utilize multimodal human neuroimaging data in older adults without Alzheimer’s disease to investigate the factors involved in the spread of tau at the earliest stages of pathology accumulation. First, we measure resting state functional connectivity between hippocampus and medial parietal cortex to show that greater connectivity strength along this pathway is associated with downstream tau pathology burden cross-sectionally, with consequences for memory function. Next, we identify networks of functional connectivity specific to either episodic memory or executive function, and show that these networks are altered by the presence of tau pathology before widespread neurodegeneration is evident. Finally, we show that baseline connectivity strength and AD pathology interact to predict longitudinal rate of tau pathology accumulation and rate of cognitive decline in a multicohort sample of cognitively unimpaired older adults. Together, this work reveals that functional connectivity can be used to better understand the extent and distribution of the earliest tau accumulation, and outlines what effects this accumulation has on changes in functional brain networks and the cognitive domains they support

A New Uniform Law for the International Sale of Goods: Is it Compatible with American Interests?

The prospects for adoption of a law gov- erning commercial\u27 contracts for the international sale of goods should be of compelling interest to American merchants and their legal advi- sors. The text which was presented to the diplomatic conference in March was completed by the United Nations Commission on Interna- tional Trade Law (UNCITRAL) in 1978.1 Its eighty-two articles em- body the substantive revisions of a similar document that was rejected by the United States sixteen years ago\u27--the 1964 Hague Convention Relating to a Uniform Law for the International Sale of Good

Crystal Balls and Tea Leaves: Predictors of Repository Success

Where are repositories headed? Let\u27s look at some predictors of repository success and spot several new approaches and features that can help time warp your library to the future. Eli Windchy is the Vice President of Consulting Services and Morgan Ziontz is a Senior Outreach Associate at bepress

A Negligence Action in Mexico: An Introduction to the Application of Mexican Law in the United States [Article]

This material published in Arizona Journal of International and Comparative Law is made available by the James E. Rogers College of Law, the Daniel F. Cracchiolo Law Library, and the University of Arizona Libraries. If you have questions, please contact the AJICL Editorial Board at http://arizonajournal.org/contact-us/

Yours, Mine, and Ours: Leveraging Individual and Community Metrics to Measure Success

How do you know when your repository initiative is successful? Over the course of this session, Morgan Ziontz, Senior Outreach Associate at bepress, will highlight some of the tools and initiatives available to help the community measure and share the success of their goals, including repository benchmarking and the new administrator dashboard. Morgan will also discuss how your benchmarking numbers and data from your dashboard can be used to gauge your progress over time

A Lawyer in Indian Country A Memoir

Intro -- Contents -- Foreword by Charles Wilkinson -- Preface -- Acknowledgment -- 1. The Road to Neah Bay -- 2. The Road to Neah Bay Begins in Chicago -- 3. The University of Chicago, the Army, and Seattle -- 4. Becoming a Lawyer -- 5. Seven Years of Lawyering in West Seattle -- 6. Creating a Law Firm -- 7. Indian Fishing Rights: Joining the Struggle -- 8. The Makahs -- 9. Recovering Lost Property: Ozette, Tatoosh, and Waadah -- 10. The Lummi Tribe -- 11. Indian Fishing Rights: Eighty Years of Suppression, Twenty Years of Confrontation -- 12. The Big Bang: U.S. v. Washington Begins -- 13. U.S. v. Washington: The Trial -- 14. U.S. v. Washington: Closing Arguments and Judge Boldt's Decision -- 15. The U.S. Supreme Court Has the Last Word: Consequences of the Boldt Decision -- 16. The Confederated Tribes of the Colville Reservation -- 17. The Northern Cheyennes Fight Strip-Mining -- 18. The Northern Cheyennes and the Hollowbreast Case -- 19. The Oliphant Case: A Setback for Tribal Government -- 20. Writing about the Indian Civil Rights Act -- 21. Leaving Law for Academia -- 22. A Firm of Tribal Attorneys -- 23. Representing Fishermen of the Alaska Peninsula -- 24. The Mille Lacs Band of Chippewas -- 25. The Wanda Boswell Case -- 26. The Northern Arapaho Tribe -- 27. Photographing the Northern Cheyennes -- 28. The Makah Whale Hunt -- 29. A Life in Being -- Notes -- Selected Bibliography -- IndexDescription based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries

Hippocampal Connectivity with Retrosplenial Cortex is Linked to Neocortical Tau Accumulation and Memory Function.

The mechanisms underlying accumulation of Alzheimer's disease (AD)-related tau pathology outside of the medial temporal lobe (MTL) in older adults are unknown but crucial to understanding cognitive decline. A growing body of evidence from human and animal studies strongly implicates neural connectivity in the propagation of tau in humans, but the pathways of neocortical tau spread and its consequences for cognitive function are not well understood. Using resting state functional magnetic resonance imaging (fMRI) and tau PET imaging from a sample of 97 male and female cognitively normal older adults, we examined MTL structures involved in medial parietal tau accumulation and associations with memory function. Functional connectivity between hippocampus (HC) and retrosplenial cortex (RsC), a key region of the medial parietal lobe, was associated with tau in medial parietal lobe. By contrast, connectivity between entorhinal cortex (EC) and RsC did not correlate with medial parietal lobe tau. Further, greater hippocampal-retrosplenial (HC-RsC) connectivity was associated with a stronger correlation between MTL and medial parietal lobe tau. Finally, an interaction between connectivity strength and medial parietal tau was associated with episodic memory performance, particularly in the visuospatial domain. This pattern of tau accumulation thus appears to reflect pathways of neural connectivity, and propagation of tau from EC to medial parietal lobe via the HC may represent a critical process in the evolution of cognitive dysfunction in aging and AD.SIGNIFICANCE STATEMENT The accumulation of tau pathology in the neocortex is a fundamental process underlying Alzheimer's disease (AD). Here, we use functional connectivity in cognitively normal older adults to track the accumulation of tau in the medial parietal lobe, a key region for memory processing that is affected early in the progression of AD. We show that the strength of connectivity between the hippocampus (HC) and retrosplenial cortex (RsC) is related to medial parietal tau burden, and that these tau and connectivity measures interact to associate with episodic memory performance. These findings establish the HC as the origin of medial parietal tau and implicate tau pathology in this region as a crucial marker of the beginnings of AD

HAI 2018 Abstract

Human Amyloid Imaging 2018 Abstrac