37 research outputs found
Training staff and creation system of educatin in opened nuclear cities in Russia
The paper deals with the problem of training, the creation of the education system in nuclear closed cities of the country.Π ΡΠ°Π±ΠΎΡΠ΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ ΠΊΠ°Π΄ΡΠΎΠ², ΡΠΎΠ·Π΄Π°Π½ΠΈΠ΅ ΡΠΈΡΡΠ΅ΠΌΡ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π² Π·Π°ΠΊΡΡΡΡΡ
Π°Π΄ΠΌΠΈΠ½ΠΈΡΡΡΠ°ΡΠΈΠ²Π½ΠΎ-ΡΠ΅ΡΡΠΈΡΠΎΡΠΈΠ°Π»ΡΠ½ΡΡ
ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡΡ
, ΡΠ²ΡΠ·Π°Π½Π½ΡΡ
Ρ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ ΡΠ΄Π΅ΡΠ½ΠΎΠΉ ΠΎΡΡΠ°ΡΠ»ΠΈ ΡΡΡΠ°Π½Ρ
Irradiation embrittlement in pure chromium and chromium-tungsten alloy in a view of their potential application for fusion plasma facing components
Treatment of pain syndrome after aesthetic breast surgery with botulinum toxin type A
Objective.Β To justify the possibility of using botulotoxin type A for the prevention of pain syndrome after aesthetic endoprosthesis of the mammary glands.Material and Methods. The study included 72 women aged between 21 and 45 to whom were scheduled to perform breast endoprosthesis with silicone implants. All patients were divided into two groups: the first group included 38, the second group β 34 people. Two weeks before the expected date of surgery, botulotoxin type A in an amount of 100 U was injected into the patients of the first group to reduce pain syndrome in the pectoralis major muscle. Patients of the second (control) group were injected with a 0.9% NaCl solution (placeboΒ effect) into the pectoralis major muscle. All patients underwent electroneuromyography (ENMG) to assess the denervation of the pectoralis major muscle before drug administration and two weeks after.Results. The intensity of pain syndrome was evaluated on the 1st-2nd day after surgery using a special questionnaire. In women of the first group, who were injected with botulinum toxin type A two weeks prior the intended surgery, a decrease in the intensity of the pain syndrome was observed, which in most cases allowed not to take analgesics at all. In women of the second group who were injected with a 0.9% NaCl solution, the severity of the pain syndrome reached its maximum values (according to the questionnaire), which required the prescription of analgesics, including narcotic ones, to reduce the severity of the pain syndrome. According to ENMG, when using botulotoxin type A by injecting into the pectoralis major muscle, denervation indices reached 55% compared to the initial ones, while using the saline solution, the ENMG indices did not change.Conclusion. Clinical use of botulotoxin type A injections into the pectoralis major muscle will improve the results of pain syndrome treatment after endoprosthetics of the mammary glands with implants in aesthetic surgery
An All-Cryogenic THz Transmission Spectrometer
This paper describes a THz transmission spectrometer for the spectral range
of 2-65 cm^-1 (100 GHz to 2 THz) with a spectral resolution of at least 1.8
cm^-1 (50 GHz) where the source, sample, and detector are all fully contained
in a cryogenic environment. Cyclotron emission from a two-dimensional electron
gas heated with an electrical current serves as a magnetic field tunable
source. The spectrometer is demonstrated at 4.2 K by measuring the resonant
cyclotron absorption of a second two dimensional electron gas. Unique aspects
of the spectrometer are that 1) an ultra-broadband detector is used and 2) the
emitter is run quasi-continuously with a chopping frequency of only 1 Hz. Since
optical coupling to room temperature components is not necessary, this
technique is compatible with ultra-low temperature (sub 100 mK) operation.Comment: 7 pages, 5 figures. Author affiliation and funding acknowledgements
clarifie
Effectiveness of Autologous Platelet-Rich Plasma and Stromal Vascular Fraction in Autologous Skin Grafting
Introduction:Β Despite the medical advances, burns remain a serious challenge and require new and promising treatment options, such as biomedical technologies with a high potential for burn wound treatment. However, high cost and complexity of biotechnologies limit their routine use, but autologous tissues, such as stromal vascular fraction (SVF) and autologous platelet-rich plasma (PRP), overcome these shortcomings.Β Β Objective:Β To demonstrate a successful case of using a combination of adipose-derived SVF and autologous PRP during autologous skin grafting in a severely burned patient.Β Β Material and methods:Β We present a successful case of 84-year-old Patient B. treated at Saint Petersburg I. I. Dzhanelidze Research Institute of Emergency Medicine in September-October 2022. He was diagnosed with a 11% (6%) / II-III degree flame burn of the head, neck, trunk, and upper extremities and first-degree inhalation injury. At the first stage, the general condition of the patient was stabilized, and he was prepared for surgery. At the second stage, on day 25 of treatment we performed skin grafting using split-thickness autografts with rare perforations and application of SVF and autologous PRP on a burn wound. We evaluated the treatment effectiveness using planimetry, cytology, and histology.Β Β Results:Β We observed complete engraftment of the autograft with no lysis or rejection during the first dressing change on day 3 after surgery and complete skin restoration on day 11. Cytologic findings over time showed an active decrease in inflammatory cells and an increase in regenerative cells, indicating successful wound healing. Histology demonstrated formation of normal stratified squamous epithelium with areas of hyperkeratosis and young granulation tissue in the superficial layers of the dermis on day 6.Β Β Conclusions:Β Our case demonstrated that the combination of SVF and autologous PRP facilitates split-thickness skin autograft engraftment
Multiple Parton Interactions in Z+jets production at the LHC. A comparison of factorized and non--factorized double parton distribution functions
We examine the contribution of Multiple Parton Interactions to Z+n-jets
production at the LHC, n=2,3,4, where the Z boson is assumed to decay
leptonically. We compare the results obtained with the correlated GS09 double
parton distribution function with those obtained with two instances of fully
factorized single parton distribution functions: MSTW2008LO and CTEQ6LO. It
appears quite feasible to measure the MPI contribution to Z+2/3/4 jets already
in the first phase of the LHC with a total luminosity of one inverse femtobarn
at 7 TeV. If as expected the trigger threshold for single photons is around 80
GeV, Z+2-jets production may well turn out to be more easily observable than
the gamma+3-jets channel. The MPI cross section is dominated by relatively soft
events with two jets balancing in transverse momentum.Comment: 15 pages, 3 plot
Structural insights into thrombolytic activity of destabilase from medicinal leech
Destabilase from the medical leech Hirudo medicinalis belongs to the family of i-type lysozymes. It has two different enzymatic activities: microbial cell walls destruction (muramidase activity), and dissolution of the stabilized fibrin (isopeptidase activity). Both activities are known to be inhibited by sodium chloride at near physiological concentrations, but the structural basis remains unknown. Here we present two crystal structures of destabilase, including a 1.1Β Γ
-resolution structure in complex with sodium ion. Our structures reveal the location of sodium ion between Glu34/Asp46 residues, which were previously recognized as a glycosidase active site. While sodium coordination with these amino acids may explain inhibition of the muramidase activity, its influence on previously suggested Ser49/Lys58 isopeptidase activity dyad is unclear. We revise the Ser49/Lys58 hypothesis and compare sequences of i-type lysozymes with confirmed destabilase activity. We suggest that the general base for the isopeptidase activity is His112 rather than Lys58. pKa calculations of these amino acids, assessed through the 1Β ΞΌs molecular dynamics simulation, confirm the hypothesis. Our findings highlight the ambiguity of destabilase catalytic residues identification and build foundations for further research of structureβactivity relationship of isopeptidase activity as well as structure-based protein design for potential anticoagulant drug development.</p
A New Method for Treating Burn Wounds Using Targeted Delivery of Medicinal Substances by Magnetic Nanocarrier (Experimental Part)
ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π½Π° Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
ΠΏΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π°Π΄ΡΠ΅ΡΠ½ΠΎΠΉ Π΄ΠΎΡΡΠ°Π²ΠΊΠΈ ΠΌΠ°Π·ΠΈ Π»Π΅Π²ΠΎΠΌΠ΅ΠΊΠΎΠ»Ρ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΌΠ°Π³Π½ΠΈΡΠ½ΡΡ
Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡ ΠΈ Π²Π½Π΅ΡΠ½Π΅Π³ΠΎ ΠΌΠ°Π³Π½ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ»Ρ ΠΏΡΠΈ ΡΠ΅ΡΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΠΆΠΎΠ³Π°Ρ
. Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΡΠΈΠ½ΠΈΠΌΠ°Π»ΠΎ
ΡΡΠ°ΡΡΠΈΠ΅ 20 ΠΊΡΡΡ Ρ Π΄Π²ΡΠΌΡ ΠΎΡΠ°Π³Π°ΠΌΠΈ ΠΎΠΆΠΎΠ³Π°. ΠΡΡΡΡ Π±ΡΠ»ΠΈ ΡΠ°Π·Π΄Π΅Π»Π΅Π½Ρ Π½Π° 4 Π³ΡΡΠΏΠΏΡ: Π±Π΅Π· Π»Π΅ΡΠ΅Π½ΠΈΡ,
ΡΠ΅ΡΠ°ΠΏΠΈΡ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΌΠ°Π·ΠΈ Π»Π΅Π²ΠΎΠΌΠ΅ΠΊΠΎΠ»Ρ, Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡ, ΠΌΠ°Π·ΠΈ
Π»Π΅Π²ΠΎΠΌΠ΅ΠΊΠΎΠ»Ρ ΠΈ Π²Π½Π΅ΡΠ½Π΅Π³ΠΎ ΠΌΠ°Π³Π½ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ»Ρ ΠΈ ΡΠΎΠ»ΡΠΊΠΎ ΠΌΠ°Π³Π½ΠΈΡΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ. ΠΡΠΈ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ Π½Π° 14-Π΅ ΡΡΡΠΊΠΈ Π²ΠΎ Π²ΡΠ΅Ρ
Π³ΡΡΠΏΠΏΠ°Ρ
Π² Π·ΠΎΠ½Π΅ ΡΠ΅ΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ ΠΊΠΎΠΆΠΈ Π±ΡΠ»ΠΈ
ΠΎΡΠΌΠ΅ΡΠ΅Π½Ρ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΈ Π³Π»ΡΠ±ΠΎΠΊΠΎΠ³ΠΎ ΠΎΠΆΠΎΠ³Π° III ΠΈ IV ΡΡΠ΅ΠΏΠ΅Π½ΠΈ Ρ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½ΠΈΠ΅ΠΌ Π½Π΅ΠΊΡΠΎΠ·Π° Π½Π° Π²ΡΡ
Π³Π»ΡΠ±ΠΈΠ½Ρ Π΄Π΅ΡΠΌΡ ΠΈ Π½Π° ΠΌΡΡΡΡ. Π Π³ΡΡΠΏΠΏΠ΅ Ρ Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡΠ°ΠΌΠΈ, ΠΌΠ°Π·ΡΡ Π»Π΅Π²ΠΎΠΌΠ΅ΠΊΠΎΠ»Ρ ΠΈ ΠΌΠ°Π³Π½ΠΈΡΠ½ΡΠΌ ΠΏΠΎΠ»Π΅ΠΌ
Π½Π° ΡΠΎΠ½Π΅ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΡ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΡ ΠΎΡΠΌΠ΅ΡΠ°Π»ΠΎΡΡ ΠΎΡΠ°Π³ΠΎΠ²ΠΎΠ΅ ΠΏΠΎΡΠ²Π»Π΅Π½ΠΈΠ΅ Π³ΡΠ°Π½ΡΠ»ΡΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ. Π’Π°ΠΊΠΈΠΌ
ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΎΠΆΠΎΠ³ΠΎΠ²ΠΎΠ³ΠΎ ΡΠ°Π½Π΅Π²ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ, ΡΡΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈΠ½Π½ΠΎΠ²Π°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠ°Π½ΠΎΠ·Π°ΠΆΠΈΠ²Π»ΡΡΡΠ΅Π³ΠΎ
ΡΡΠ΅Π΄ΡΡΠ²Π° Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡ Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ ΠΌΠ°Π·ΡΡ Π»Π΅Π²ΠΎΠΌΠ΅ΠΊΠΎΠ»Ρ ΡΠ»ΡΡΡΠ°Π΅Ρ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΡ ΡΠΊΠ°Π½Π΅ΠΉ ΠΈ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΡΠΊΠΎΡΠ΅Π½ΠΈΡ ΡΠΏΠΈΡΠ΅Π»ΠΈΠ·Π°ΡΠΈΠΈ, ΡΡΠΎ Π² ΡΠ΅Π»ΠΎΠΌ ΠΏΠΎΠ²ΡΡΠ°Π΅Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΎΠΆΠΎΠ³ΠΎΠ²ΠΎΠΉ
ΡΠ°Π½Ρ. ΠΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ Π²Π½Π΅ΡΠ½Π΅Π³ΠΎ ΠΌΠ°Π³Π½ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ»Ρ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΠ΅Ρ Π°Π΄ΡΠ΅ΡΠ½ΠΎΠΉ Π΄ΠΎΡΡΠ°Π²ΠΊΠ΅ Π»Π΅ΡΠ΅Π±Π½ΠΎΠ³ΠΎ
Π½Π°Π½ΠΎΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΠΈ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠ°Π½ΠΈΡ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠΉ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° Π² ΡΠ°Π½Π΅Experimental studies have been carried out on laboratory animals to investigate the effectiveness of targeted delivery of levomekol ointment using magnetic nanoparticles and an external magnetic field for treatment of thermal burns. The study involved 20 rats, with two burns on each. The rats were divided into 4 groups: untreated; treated with levomekol ointment; treated with levomekol ointment associated
with nanoparticles and an external magnetic field; and treated with magnetic field alone. Histological
examination was conducted on Day 14, and in all groups, in the thermal burn zone of the skin there were
signs of deep three- and four-degree
burns with necrosis spread through the dermis, reaching the muscle.
In the group with levomekol ointment associated with nanoparticles and magnetic field, inflammation
was decreased, and focal granulation tissue formation was observed. Thus, histological studies of the
burn wound process in laboratory animals showed that the use of an innovative biologically active
wound healing agent based on nanoparticles in combination with the levomecol ointment improved
tissue regeneration and accelerated epithelialization, which enhanced the effectiveness of burn wound
treatment. The use of an external magnetic field facilitated targeted delivery of the therapeutic nanosystem
and maintenance of the optimal concentration of the drug in the woun
Research and development web portal for data monitoring of cyber threat intelligence
Π ΡΠ°Π±ΠΎΡΠ΅ Π±ΡΠ»ΠΈ Π² ΠΏΠΎΠ»Π½ΠΎΠΌ ΠΎΠ±ΡΡΠΌΠ΅ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π°ΡΠΏΠ΅ΠΊΡΡ ΡΠ°Π·Π²Π΅Π΄ΠΊΠΈ ΠΎΠ± ΡΠ³ΡΠΎΠ·Π°Ρ
(threat intelligence), ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Ρ ΠΌΠ΅ΡΡΠΈΠΊΠΈ, ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΠΈ ΠΏΡΠΎΡΠ°Π½ΠΆΠΈΡΠΎΠ²Π°Π½Ρ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΈ ΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½ Π²Π΅Π±-ΠΏΠΎΡΡΠ°Π» Π΄Π»Ρ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Ρ ΠΎΡΠΎΠ±ΡΠ°Π½Π½ΡΠΌΠΈ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΡΠΌΠΈ ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠ°ΠΌΠΈ CTI. ΠΡΠ» ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½ Π²Π΅Π± ΠΏΠΎΡΡΠ°Π» Π΄Π»Ρ ΠΎΡΡΠ»Π΅ΠΆΠΈΠ²Π°Π½ΠΈΡ Π΄Π°Π½Π½ΡΡ
ΠΎΠ± ΡΠ³ΡΠΎΠ·Π°Ρ
ΠΊΠΈΠ±Π΅Ρ-Π°ΡΠ°ΠΊ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΠΌΠ΅ΡΡ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΡΡ ΠΈ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΡΡ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡ ΡΠ°ΠΊ, ΠΊΠ°ΠΊ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ ΠΏΡΠΈ ΠΏΠΎΡΡΡΠΎΠ΅Π½ΠΈΠΈ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ ΠΏΡΠ΅Π΄ΠΏΡΠΈΡΡΠΈΡ.In this work was described theoretical and practical aspects about cyber threat intelligence and information security. Information sources of cyber threat intelligence was group and ranged. Web portal for data monitoring of cyber threat intelligence was developed. The results are gained a theoretical and practical aspects for information security of enterprise
Spontaneous Terahertz Emission under Electrical Breakdown of a Shallow Acceptor in Ge
The spectra of spontaneous terahertz (THz) electroluminescence at the breakdown of shallow Ga acceptor in Ge were observed for the first time and investigated. We found and characterized the emission lines corresponding to the hole transitions between the excited states and the ground state of the impurity center as well as the transitions of the hot holes from the valence band to the impurity and within the valence band. A high quantum yield of the radiative transitions will become an important factor in designing electrically pumped THz emitters for theβ2 THz spectral range