Placental Malaria and Mother-to-Child Transmission of Human Immunodeficiency Virus-1 in Rural Rwanda

We conducted a nested case-control study of placental malaria (PM) and mother-to-child transmission (MTCT) of human immunodeficiency virus-1 (HIV-1) within a prospective cohort of 627 mother-infant pairs followed from October 1989 until April 1994 in rural Rwanda. Sixty stored placentas were examined for PM and other placental pathology, comparing 20 HIV-infected mother-infant (perinatal transmitter) pairs, 20 HIV-uninfected pairs, and 20 HIV-infected mothers who did not transmit to their infant perinatally. Of 60 placentas examined, 45% showed evidence of PM. Placental malaria was associated with increased risk of MTCT of HIV-1 (adjusted odds ratio [aOR] = 6.3; 95% confidence interval [CI] = 1.4–29.1), especially among primigravidae (aOR = 12.0; 95% CI = 1.0–150; P < 0.05). Before antiretroviral therapy or prophylaxis, PM was associated with early infant HIV infection among rural Rwandan women living in a hyper-endemic malaria region. Primigravidae, among whom malaria tends to be most severe, may be at higher risk

Time-division SQUID multiplexers with reduced sensitivity to external magnetic fields

Time-division SQUID multiplexers are used in many applications that require exquisite control of systematic error. One potential source of systematic error is the pickup of external magnetic fields in the multiplexer. We present measurements of the field sensitivity figure of merit, effective area, for both the first stage and second stage SQUID amplifiers in three NIST SQUID multiplexer designs. These designs include a new variety with improved gradiometry that significantly reduces the effective area of both the first and second stage SQUID amplifiers.Comment: 4 pages, 7 figures. Submitted for publication in the IEEE Transactions on Applied Superconductivity, August 201

Optimierung von Saatgutbehandlungsmitteln mit Wirkung gegen Flugbrand an Gerste und Weizen (Ustilago nuda, U. tritici) unter Nutzung verbesserter Verfahren zum Nachweis der Erreger

Ziel des Projektes war die Entwicklung von Saatgutbehandlungsmitteln zur Flugbrandbekämpfung im Ökolandbau und von Techniken die geeignet sind, die Entwicklung solcher Saatgutbehandlungsmittel zu beschleunigen. In Inokulationsversuchen konnte im Feldversuch durch Ausstäuben von Sporen Saatgut mit 2-5% Flugbrandbefall erzeugt werden. Nach Einzelblüteninokulation lag der Befall oft über 60%. Anders als bei Weizen waren bei Gerste die Keimfähigkeit und das Tausendkorngewicht von solchem Saatgut deutlich reduziert. Von ca. 30 geprüften Pflanzenextrakten führten neun nach Inkorporation in PDA zu einer vollständigen Hemmung der Brandsporenkeimung. In Hemmtesten mit Mikroorganismen betrug der Anteil wirksamer Isolate bei den Trichoderma-Isolaten 43%, bei den Actinomyceten 30% und bei den übrigen Bakterien 11%. In mehrjährig durchgeführten Kleinparzellenversuchen mit flugbrandinfizierter Gerste und Weizen wurden mit einigen Behandlungsvarianten Bekämpfungserfolge erzielt. Die Effekte waren aber zu gering für die praktische Anwendung und nur bedingt reproduzierbar. Topfversuche im Gewächshaus mit hochinfizierten Saatgutchargen erbrachten ähnliche Ergebnisse. Die Wirksamkeit gegen Haferflugbrand wurde nur einmal überprüft. Wie im Falle von Gersten- und Weizenflugbrand war der Bekämpfungserfolg auch beim Haferflugbrand unbefriedigend. Eine Ausnahme bildete die Saatgutbehandlung mit Ethanol (70%). Mit ihr wurde bei Hafer eine Flugbrandwirksamkeit von ca. 80% erzielt. Nach Anfärbung mit dem Fluoreszenzfarbstoff Blankophor wurde beobachtet, dass der Pilz schon wenige Tage nach Beginn der Keimung in das Apikalmeristem und die Blattprimordien eindrang. Im 1-Knotenstadium waren die Ährenanlagen meist völlig besiedelt. Ein Protokoll für einen immunologischen (ELISA) und für einen molekularbiologischen (real-time PCR) Nachweis wurde entwickelt und zur Quantifizierung des Pilzes in Jungpflanzen angewendet. Die mit beiden Methoden erhaltenen Daten stimmten gut überein. In weiteren Versuchen konnte die Anwendbarkeit des mikroskopischen Nachweises und des ELISA für die Entwicklung von Saatgutbehandlungsmitteln und –verfahren exemplarisch gezeigt werden

TARGET: A Digitizing And Trigger ASIC For The Cherenkov Telescope Array

The future ground-based gamma-ray observatory Cherenkov Telescope Array (CTA) will feature multiple types of imaging atmospheric Cherenkov telescopes, each with thousands of pixels. To be affordable, camera concepts for these telescopes have to feature low cost per channel and at the same time meet the requirements for CTA in order to achieve the desired scientific goals. We present the concept of the TeV Array Readout Electronics with GSa/s sampling and Event Trigger (TARGET) Application Specific Circuit (ASIC), envisaged to be used in the cameras of various CTA telescopes, e.g. the Gamma-ray Cherenkov Telescope (GCT), a proposed 2-Mirror Small-Sized Telescope, and the Schwarzschild-Couder Telescope (SCT), a proposed Medium-Sized Telescope. In the latest version of this readout concept the sampling and trigger parts are split into dedicated ASICs, TARGET C and T5TEA, both providing 16 parallel input channels. TARGET C features a tunable sampling rate (usually 1 GSa/s), a 16k sample deep buffer for each channel and on-demand digitization and transmission of waveforms with typical spans of ~100 ns. The trigger ASIC, T5TEA, provides 4 low voltage differential signal (LVDS) trigger outputs and can generate a pedestal voltage independently for each channel. Trigger signals are generated by T5TEA based on the analog sum of the input in four independent groups of four adjacent channels and compared to a threshold set by the user. Thus, T5TEA generates four LVDS trigger outputs, as well as 16 pedestal voltages fed to TARGET C independently for each channel. We show preliminary results of the characterization and testing of TARGET C and T5TEA.Comment: 6 pages, 8 figures, Proceedings of the 6th International Symposium on High-Energy Gamma-Ray Astronomy (Gamma2016

TARGET: toward a solution for the readout electronics of the Cherenkov Telescope Array

TARGET is an application specific integrated circuit (ASIC) designed to read out signals recorded by the photosensors in cameras of very-high-energy gamma-ray telescopes exploiting the imaging of Cherenkov radiation from atmospheric showers. TARGET capabilities include sampling at a high rate (typically 1 GSample/s), digitization, and triggering on the sum of four adjacent pixels. The small size, large number of channels read out per ASIC (16), low cost per channel, and deep buffer for trigger latency (~16 $\mu$s at 1 GSample/s) make TARGET ideally suited for the readout in systems with a large number of telescopes instrumented with compact photosensors like multi-anode or silicon photomultipliers combined with dual-mirror optics. The possible advantages of such systems are better sensitivity, a larger field of view, and improved angular resolution. The two latest generations of TARGET ASICs, TARGET 5 and TARGET 7, are soon to be used for the first time in two prototypes of small-sized and medium-sized dual-mirror telescopes proposed in the framework of the Cherenkov Telescope Array (CTA) project. In this contribution we report on the performance of the TARGET ASICs and discuss future developments.Comment: 8 pages, 3 figures. In Proceedings of the 34th International Cosmic Ray Conference (ICRC2015), The Hague, The Netherlands. All CTA contributions at arXiv:1508.0589

Multi-patch methods in general relativistic astrophysics - I. Hydrodynamical flows on fixed backgrounds

Many systems of interest in general relativistic astrophysics, including neutron stars, accreting compact objects in X-ray binaries and active galactic nuclei, core collapse, and collapsars, are assumed to be approximately spherically symmetric or axisymmetric. In Newtonian or fixed-background relativistic approximations it is common practice to use spherical polar coordinates for computational grids; however, these coordinates have singularities and are difficult to use in fully relativistic models. We present, in this series of papers, a numerical technique which is able to use effectively spherical grids by employing multiple patches. We provide detailed instructions on how to implement such a scheme, and present a number of code tests for the fixed background case, including an accretion torus around a black hole.Comment: 26 pages, 20 figures. A high-resolution version is available at http://www.cct.lsu.edu/~bzink/papers/multipatch_1.pd

Accurate evolutions of unequal-mass neutron-star binaries: properties of the torus and short GRB engines

We present new results from accurate and fully general-relativistic simulations of the coalescence of unmagnetized binary neutron stars with various mass ratios. The evolution of the stars is followed through the inspiral phase, the merger and prompt collapse to a black hole, up until the appearance of a thick accretion disk, which is studied as it enters and remains in a regime of quasi-steady accretion. Although a simple ideal-fluid equation of state with \Gamma=2 is used, this work presents a systematic study within a fully general relativistic framework of the properties of the resulting black-hole--torus system produced by the merger of unequal-mass binaries. More specifically, we show that: (1) The mass of the torus increases considerably with the mass asymmetry and equal-mass binaries do not produce significant tori if they have a total baryonic mass M_tot >~ 3.7 M_sun; (2) Tori with masses M_tor ~ 0.2 M_sun are measured for binaries with M_tot ~ 3.4 M_sun and mass ratios q ~ 0.75-0.85; (3) The mass of the torus can be estimated by the simple expression M_tor(q, M_tot) = [c_1 (1-q) + c_2](M_max-M_tot), involving the maximum mass for the binaries and coefficients constrained from the simulations, and suggesting that the tori can have masses as large as M_tor ~ 0.35 M_sun for M_tot ~ 2.8 M_sun and q ~ 0.75-0.85; (4) Using a novel technique to analyze the evolution of the tori we find no evidence for the onset of non-axisymmetric instabilities and that very little, if any, of their mass is unbound; (5) Finally, for all the binaries considered we compute the complete gravitational waveforms and the recoils imparted to the black holes, discussing the prospects of detection of these sources for a number of present and future detectors.Comment: 35 pages; small changes to match the published versio

Efficient spin transport through native oxides of nickel and permalloy with platinum and gold overlayers

We present measurements of spin pumping detected by the inverse spin Hall effect voltage and ferromagnetic resonance spectroscopy in a series of metallic ferromagnet/normal metal thin film stacks. We compare heterostructures grown in situ to those where either a magnetic or nonmagnetic oxide is introduced between the two metals. The heterostructures, either nickel with a platinum overlayer (Ni/Pt) or the nickel-iron alloy permalloy (Py) with a gold overlayer (Py/Au), were also characterized in detail using grazing-incidence x-ray reflectivity, Auger electron spectroscopy, and both SQUID and alternating-gradient magnetometry. We verify the presence of oxide layers, characterize layer thickness, composition, and roughness, and probe saturation magnetization, coercivity, and anisotropy. The results show that while the presence of a nonmagnetic oxide at the interface suppresses spin transport from the ferromagnet to the nonmagnetic metal, a thin magnetic oxide (here the native oxide formed on both Py and Ni) somewhat enhances the product of the spin-mixing conductance and the spin Hall angle. We also observe clear evidence of an out-of-plane component of magnetic anisotropy in Ni/Pt samples that is enhanced in the presence of the native oxide, resulting in perpendicular exchange bias. Finally, the dc inverse spin Hall voltages generated at ferromagnetic resonance in our Py/Au samples are large, and suggest values for the spin Hall angle in gold of 0.04<αSH<0.22, in line with the highest values reported for Au. This is interpreted as resulting from Fe impurities. We present indirect evidence that the Au films described here indeed have significant impurity levels.B.L.Z. and D.B. gratefully acknowledge support from the NSF (Grants No. DMR-0847796 and No. DMR-1410247). B.L.Z. also thanks the University of Minnesota Chemical Engineering and Materials Science Department, as a portion of this work benefited from support of the George T. Piercy Distinguished Visiting Professorship. Work at the University of Minnesota was supported primarily by the NSF under Grant No. DMR-1507048, with additional support from the NSF MRSEC under Grant No. DMR-1420013. The work at WMI is supported by Deutsche Forschungsgemeinschaft via SPP 1538 Spin-Caloric Transport (Project No. GO 944/4-1). Parts of this work were carried out in the Characterization Facility, University of Minnesota, which receives partial support from NSF through the MRSEC program. This work was performed, in part, at the Center for Integrated Nanotechnologies, an Office of Science User Facility operated for the US Department of Energy (DOE) Office of Science by Los Alamos National Laboratory (Contract No. DE-AC52-06NA25396) and Sandia National Laboratories (Contract No. DE-AC04-94AL85000)

AMR, stability and higher accuracy

Efforts to achieve better accuracy in numerical relativity have so far focused either on implementing second order accurate adaptive mesh refinement or on defining higher order accurate differences and update schemes. Here, we argue for the combination, that is a higher order accurate adaptive scheme. This combines the power that adaptive gridding techniques provide to resolve fine scales (in addition to a more efficient use of resources) together with the higher accuracy furnished by higher order schemes when the solution is adequately resolved. To define a convenient higher order adaptive mesh refinement scheme, we discuss a few different modifications of the standard, second order accurate approach of Berger and Oliger. Applying each of these methods to a simple model problem, we find these options have unstable modes. However, a novel approach to dealing with the grid boundaries introduced by the adaptivity appears stable and quite promising for the use of high order operators within an adaptive framework