A distinct bacterial dysbiosis associated skin inflammation in ovine footrot

Ovine footrot is a highly prevalent bacterial disease caused by Dichelobacter nodosus and characterised by the separation of the hoof horn from the underlying skin. The role of innate immune molecules and other bacterial communities in the development of footrot lesions remains unclear. This study shows a significant association between the high expression of IL1β and high D. nodosus load in footrot samples. Investigation of the microbial population identified distinct bacterial populations in the different disease stages and also depending on the level of inflammation. Treponema (34%), Mycoplasma (29%) and Porphyromonas (15%) were the most abundant genera associated with high levels of inflammation in footrot. In contrast, Acinetobacter (25%), Corynebacteria (17%) and Flavobacterium (17%) were the most abundant genera associated with high levels of inflammation in healthy feet. This demonstrates for the first time there is a distinct microbial community associated with footrot and high cytokine expression

Trading off quality and complexity for a HVQ-based video codec on portable devices

Bandwidth and processing requirements of multimedia applications typically exceed capabilities of portable terminals with current technology. Applications should hence be able to accommodate their requirements to run on these devices. In this paper, we provide a performance characterization of a video codec based on techniques such as hierarchical vector quantization which trade off complexity and reproduction quality. Comparison with standard codecs shows a remarkable reduction of coding times, such that real-time coding/decoding of video becomes possible even on low-power devices. This complexity reduction is counterbalanced by reproduction quality impairment. Nevertheless, for application such as video-conference, subjective quality seems to be fairly acceptable. Our analysis also quantifies some limitations of low-power devices with current technology. © 2005 Elsevier Inc. All rights reserved

Silent occult choroidal vascular abnormalities.

To describe clinically occult choroidal vascular abnormalities that can be revealed by indocyanine green (ICG) angiography