Benchmarking Segmentation Models with Mask-Preserved Attribute Editing

When deploying segmentation models in practice, it is critical to evaluate their behaviors in varied and complex scenes. Different from the previous evaluation paradigms only in consideration of global attribute variations (e.g. adverse weather), we investigate both local and global attribute variations for robustness evaluation. To achieve this, we construct a mask-preserved attribute editing pipeline to edit visual attributes of real images with precise control of structural information. Therefore, the original segmentation labels can be reused for the edited images. Using our pipeline, we construct a benchmark covering both object and image attributes (e.g. color, material, pattern, style). We evaluate a broad variety of semantic segmentation models, spanning from conventional close-set models to recent open-vocabulary large models on their robustness to different types of variations. We find that both local and global attribute variations affect segmentation performances, and the sensitivity of models diverges across different variation types. We argue that local attributes have the same importance as global attributes, and should be considered in the robustness evaluation of segmentation models. Code: https://github.com/PRIS-CV/Pascal-EA.Comment: CVPR 202

Twofold Symmetry Observed in Bi2_{2}Te3_{3}/FeTe Interfacial Superconductor

Superconducting pairing symmetry are crucial in understanding the microscopic superconducting mechanism of a superconductor. Here we report the observation of a twofold superconducting gap symmetry in an interfacial superconductor Bi$_{2}$Te$_{3}$/FeTe, by employing quasiparticle interference (QPI) technique in scanning tunneling microscopy and macroscopic magnetoresistance measurements. The QPI patterns corresponding to energies inside and outside the gap reveal a clear anisotropic superconducting gap. Furthermore, both the in-plane angle-dependent magnetoresistance and in-plane upper critical field exhibit a clear twofold symmetry. This twofold symmetry align with the Te-Te direction in FeTe, which weakens the possible generation by bi-collinear antiferromagnetism order. Our finding provides key information in further understanding of the topological properties in Bi$_{2}$Te$_{3}$/FeTe superconducting system and propels further theoretical interests in the paring mechanism in the system

Double-Stranded RNA of Intestinal Commensal but Not Pathogenic Bacteria Triggers Production of Protective Interferon-β

SummaryThe small intestine harbors a substantial number of commensal bacteria and is sporadically invaded by pathogens, but the response to these microorganisms is fundamentally different. We identified a discriminatory sensor by using Toll-like receptor 3 (TLR3). Double-stranded RNA (dsRNA) of one major commensal species, lactic acid bacteria (LAB), triggered interferon-β (IFN-β) production, which protected mice from experimental colitis. The LAB-induced IFN-β response was diminished by dsRNA digestion and treatment with endosomal inhibitors. Pathogenic bacteria contained less dsRNA and induced much less IFN-β than LAB, and dsRNA was not involved in pathogen-induced IFN-β induction. These results identify TLR3 as a sensor to small intestinal commensal bacteria and suggest that dsRNA in commensal bacteria contributes to anti-inflammatory and protective immune responses

Increased recruitment of endogenous stem cells and chondrogenic differentiation by a composite scaffold containing bone marrow homing peptide for cartilage regeneration

Even small cartilage defects could finally degenerate to osteoarthritis if left untreated, owing to the poor self-healing ability of articular cartilage. Stem cell transplantation has been well implemented as a common approach in cartilage tissue engineering but has technical complexity and safety concerns. The stem cell homing-based technique emerged as an alternative promising therapy for cartilage repair to overcome traditional limitations. In this study, we constructed a composite hydrogel scaffold by combining an oriented acellular cartilage matrix (ACM) with a bone marrow homing peptide (BMHP)-functionalized self-assembling peptide (SAP). We hypothesized that increased recruitment of endogenous stem cells by the composite scaffold could enhance cartilage regeneration. Methods: To test our hypothesis, in vitro proliferation, attachment and chondrogenic differentiation of rabbit mesenchymal stem cells (MSCs) were tested to confirm the bioactivities of the functionalized peptide hydrogel. The composite scaffold was then implanted into full-thickness cartilage defects on rabbit knee joints for cartilage repair, in comparison with microfracture or other sample groups. Stem cell recruitment was monitored by dual labeling with CD29 and CD90 under confocal microcopy at 1 week after implantation, followed by chondrogenic differentiation examined by qRT-PCR. Repaired tissue of the cartilage defects was evaluated by histological and immunohistochemistry staining, microcomputed tomography (micro-CT) and magnetic resonance imaging (MRI) at 3 and 6 months post-surgery. Macroscopic and histological scoring was done to evaluate the optimal in vivo repair outcomes of this composite scaffold. Results: The functionalized SAP hydrogels could stimulate rabbit MSC proliferation, attachment and chondrogenic differentiation during in vitro culture. At 7 days after implantation, increased recruitment of MSCs based on CD29(+)/CD90(+) double-positive cells was found in vivo in the composite hydrogel scaffold, as well as upregulation of cartilage-associated genes (aggrecan, Sox9 and type II collagen). After 3 and 6 months post-surgery, the articular cartilage defect in the composite scaffold-treated group was fully covered with cartilage-like tissue with a smooth surface, which was similar to the surrounding native cartilage, according to the results of histological and immunohistochemistry staining, micro-CT and MRI analysis. Macroscopic and histological scoring confirmed that the quality of cartilage repair was significantly improved with implantation of the composite scaffold at each timepoint, in comparison with microfracture or other sample groups. Conclusion: Our findings demonstrated that the composite scaffold could enhance endogenous stem cell homing and chondrogenic differentiation and significantly improve the therapeutic outcome of chondral defects. The present study provides a promising approach for in vivo cartilage repair without cell transplantation. Optimization of this strategy may offer great potential and benefits for clinical application in the future

Discutindo a educação ambiental no cotidiano escolar: desenvolvimento de projetos na escola formação inicial e continuada de professores

A presente pesquisa buscou discutir como a Educação Ambiental (EA) vem sendo trabalhada, no Ensino Fundamental e como os docentes desta escola compreendem e vem inserindo a EA no cotidiano escolar., em uma escola estadual do município de Tangará da Serra/MT, Brasil. Para tanto, realizou-se entrevistas com os professores que fazem parte de um projeto interdisciplinar de EA na escola pesquisada. Verificou-se que o projeto da escola não vem conseguindo alcançar os objetivos propostos por: desconhecimento do mesmo, pelos professores; formação deficiente dos professores, não entendimento da EA como processo de ensino-aprendizagem, falta de recursos didáticos, planejamento inadequado das atividades. A partir dessa constatação, procurou-se debater a impossibilidade de tratar do tema fora do trabalho interdisciplinar, bem como, e principalmente, a importância de um estudo mais aprofundado de EA, vinculando teoria e prática, tanto na formação docente, como em projetos escolares, a fim de fugir do tradicional vínculo “EA e ecologia, lixo e horta”.Facultad de Humanidades y Ciencias de la Educació

The Impact of Chinese Carbon Emissions Trading System on Efficiency of Enterprise Capital Allocation: Effect Identification and Mechanism Test

The carbon emission trading system, as a significant policy instrument to ensure the Chinese economy achieves a green and low carbon transition, will also affect economic enterprise efficiency. This paper takes listed enterprises in a Chinese carbon trading pilot from 2011 to 2020 as research samples, constructs a multi-period differential model, and explores the impact of Chinese the carbon emission trading system on enterprise capital allocation efficiency. We find that the Chinese carbon emission trading system effectively improves the capital allocation efficiency of enterprises, which is more significant in enterprises with light pollution intensity and strong regional environmental regulation. Further analysis shows that the carbon emission trading system can improve the efficiency of enterprise capital allocation by improving the efficiency of working capital management and asset operation efficiency, while the path of human capital value is not established. Carbon trading market activity and government efficiency play a positive moderating role in the impact of the carbon emission trading system on enterprise capital allocation efficiency. The higher carbon trading market activity and government efficiency, the stronger the relationship between them. The above conclusions provide empirical evidence for the microeconomic effects of the Chinese carbon emission trading system, and also provide a useful reference for the government to implement carbon trading according to local conditions and improve the efficiency of enterprise capital allocation

The Impact of Chinese Carbon Emissions Trading System on Efficiency of Enterprise Capital Allocation: Effect Identification and Mechanism Test

The carbon emission trading system, as a significant policy instrument to ensure the Chinese economy achieves a green and low carbon transition, will also affect economic enterprise efficiency. This paper takes listed enterprises in a Chinese carbon trading pilot from 2011 to 2020 as research samples, constructs a multi-period differential model, and explores the impact of Chinese the carbon emission trading system on enterprise capital allocation efficiency. We find that the Chinese carbon emission trading system effectively improves the capital allocation efficiency of enterprises, which is more significant in enterprises with light pollution intensity and strong regional environmental regulation. Further analysis shows that the carbon emission trading system can improve the efficiency of enterprise capital allocation by improving the efficiency of working capital management and asset operation efficiency, while the path of human capital value is not established. Carbon trading market activity and government efficiency play a positive moderating role in the impact of the carbon emission trading system on enterprise capital allocation efficiency. The higher carbon trading market activity and government efficiency, the stronger the relationship between them. The above conclusions provide empirical evidence for the microeconomic effects of the Chinese carbon emission trading system, and also provide a useful reference for the government to implement carbon trading according to local conditions and improve the efficiency of enterprise capital allocation