Edge Cache-based ISP-CP Collaboration Scheme for Content Delivery Services

With the explosive increase of mobile data traffic, content delivery issue in the Internet is a growing concern for both Internet Service Providers (ISPs) and content providers (CPs). To improve content transmission efficiency and reduce network delay, many ISP-CP cooperation schemes are designed, parts of which are trying to introduce the idea of in-network caching. However, the combination influence of edge cache and content popularity is largely ignored in the existing solutions. Therefore, we propose a novel edge cache-based ISP-CP collaboration model for content delivery services, where the two important factors are simultaneously taken into account. Then, the model is analyzed to obtain the maximal network profit from the perspective of online and offline, respectively. Simulation results show that the profit gains of the proposed solution over the existing Internet models only considering cooperation between ISPs and CPs in the heterogeneous network environments

Utilizing Patient-Derived Epithelial Ovarian Cancer Tumor Organoids to Predict Carboplatin Resistance

The development of patient-derived tumor organoids (TOs) from an epithelial ovarian cancer tumor obtained at the time of primary or interval debulking surgery has the potential to play an important role in precision medicine. Here, we utilized TOs to test front-line chemotherapy sensitivity and to investigate genomic drivers of carboplatin resistance. We developed six high-grade, serous epithelial ovarian cancer tumor organoid lines from tissue obtained during debulking surgery (two neoadjuvant-carboplatin-exposed and four chemo-naïve). Each organoid line was screened for sensitivity to carboplatin at four different doses (100, 10, 1, and 0.1 µM). Cell viability curves and resultant EC50 values were determined. One organoid line, UK1254, was predicted to be resistant to carboplatin based on its EC50 value (50.2 µM) being above clinically achievable Cmax. UK1254 had a significantly shorter PFS than the rest of the subjects (p = 0.0253) and was treated as a platinum-resistant recurrence. Subsequent gene expression analysis revealed extensively interconnected, differentially expressed pathways related to NF-kB, cellular differentiation (PRDM6 activation), and the linkage of B-cell receptor signaling to the PI3K–Akt signaling pathway (PI3KAP1 activation). This study demonstrates that patient-derived tumor organoids can be developed from patients at the time of primary or interval debulking surgery and may be used to predict clinical platinum sensitivity status or to investigate drivers of carboplatin resistance

The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population

The polymorphism of human leukocyte antigen (HLA), which is a genetic factor that influences the progression of hemorrhagic fever with renal syndrome (HFRS) after Hantaan virus (HTNV) infection, was incompletely understood. In this case-control study, 76 HFRS patients and 370 healthy controls of the Chinese Han population were typed for the HLA-A, -B, and -DRB1 loci. The general variation at the HLA-DRB1 locus was associated with the onset of HFRS (P<0.05). The increasing frequencies of HLA-DRB1*09 and HLA-B*46-DRB1*09 in HFRS patients were observed as reproducing a previous study. Moreover, the HLA-B*51-DRB1*09 was susceptible to HFRS (P=0.037; OR =3.62; 95% CI: 1.00–13.18). The increasing frequencies of HLA-B*46, HLA-B*46-DRB1*09, and HLA-B*51-DRB1*09 were observed almost in severe/critical HFRS patients. The mean level of maximum serum creatinine was higher in HLA-B*46-DRB1*09 (P=0.011), HLA-B*51-DRB1*09 (P=0.041), or HLA-B*46 (P=0.011) positive patients than that in the negative patients. These findings suggest that the allele HLA-B*46 and haplotypes HLA-B*46-DRB1*09 and HLA-B*51-DRB1*09 in patients could contribute to a more severe degree of HFRS and more serious kidney injury, which improve our understanding of the HLA polymorphism for a different outcome of HTNV infection

Joint Optimization of Control Strategy and Energy Consumption for Energy Harvesting WSAN

With the rapid development of wireless sensor technology, recent progress in wireless sensor and actuator networks (WSANs) with energy harvesting provide the possibility for various real-time applications. Meanwhile, extensive research activities are carried out in the fields of efficient energy allocation and control strategy design. However, the joint design considering physical plant control, energy harvesting, and consumption is rarely concerned in existing works. In this paper, in order to enhance system control stability and promote quality of service for the WSAN energy efficiency, a novel three-step joint optimization algorithm is proposed through control strategy and energy management analysis. First, the optimal sampling interval can be obtained based on energy harvesting, consumption, and remaining conditions. Then, the control gain for each sampling interval is derived by using a backward iteration. Finally, the optimal control strategy is determined as a linear function of the current plant states and previous control strategies. The application of UAV formation flight system demonstrates that better system performance and control stability can be achieved by the proposed joint optimization design for all poor, sufficient, and general energy harvesting scenarios

Deposition of Iron on Graphite Felts by Thermal Decomposition of Fe(CO)(5) for Anodic Modification of Microbial Fuel Cells

In this paper, a new efficient anodic modification method for microbial fuel cells (MFCs) was developed. Fe was deposited on graphite felt by thermo decomposition of Fe(CO)(5) and then oxidized to Fe(III) oxides. Fe(III) oxides were proved Fe2O3 and FeOOH. The unmodified and Fe modified graphite felts were utilized as anode in MFCs. Fe(III) oxides on anode promoted the power generation of MFCs. The maximum power density of 18W/m(3) and the internal resistance of 51 Omega were obtained by the MFC with Fe modified anode, which was significantly superior to the performance of the MFC with unmodified anode. The electrochemical activity and attached bacterial density of Fe modified graphite felts were significantly higher than those of the unmodified graphite felts. This new method for anodic preparation promoted power generation, replaced manual brushing and Nafion solution, and reduced the cost

Resource Allocation in OFDMA Networks With Imperfect Channel State Information

This letter investigates the effect of imperfect channel state information (CSI) on the performance of radio resource management for a downlink multi-user OFDMA system. It is shown that the imperfect CSI introduces a signal-and-power dependent noise term, which makes the symbol error rate (SER) constellation-point dependent, and yields an error floor on the SER. In addition, a two-step multi-user channel, power and constellation allocation algorithm is proposed to maximize the total network throughput

Int. J. Electrochem. Sci.

In this paper, PANI was electrochemically synthesized on graphite felt by cyclic voltammetry (CV), and PANI modified and unmodified graphite felts were utilized as anode of MFCs. The power generation of MFCs, electrochemical activity of graphite felts and anodic cell mass were compared. The maximum power density and the internal resistance of MFC with PANI modified anode were 4 W/m(3) and 156 Omega respectively, yet those of MFC with unmodified anode were 1.7 W/m(3) and 358 Omega. The startup time of MFC with PANI modified anode shortened and the electrochemical activity and cell mass of PANI modified graphite felt were significantly higher than that of the unmodified graphite felt. With no use of manual brushing and Nafion solution, the electrochemical synthesis of PANI by CV on graphite felt for anodic modification improved power generation and reduced the cost of MFCs.In this paper, PANI was electrochemically synthesized on graphite felt by cyclic voltammetry (CV), and PANI modified and unmodified graphite felts were utilized as anode of MFCs. The power generation of MFCs, electrochemical activity of graphite felts and anodic cell mass were compared. The maximum power density and the internal resistance of MFC with PANI modified anode were 4 W/m(3) and 156 Omega respectively, yet those of MFC with unmodified anode were 1.7 W/m(3) and 358 Omega. The startup time of MFC with PANI modified anode shortened and the electrochemical activity and cell mass of PANI modified graphite felt were significantly higher than that of the unmodified graphite felt. With no use of manual brushing and Nafion solution, the electrochemical synthesis of PANI by CV on graphite felt for anodic modification improved power generation and reduced the cost of MFCs